ENSG00000161179

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292778 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding protein_coding 109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 17.507170 33.34454 8.179048 1.619235 0.5342909 -2.026116 0.15981250 0.15043333 0.14116667 -0.009266667 0.8086517177 0.0001722864 FALSE  
ENST00000415762 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding nonsense_mediated_decay 109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 30.349368 63.08187 16.567995 8.047246 0.5547748 -1.928185 0.26142083 0.28083333 0.28553333 0.004700000 0.9597171447 0.0001722864 FALSE  
ENST00000464015 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding retained_intron 109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 16.540098 26.46436 10.639917 1.205684 0.6219309 -1.313754 0.17137083 0.11943333 0.18336667 0.063933333 0.0001722864 0.0001722864 FALSE  
ENST00000468686 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding retained_intron 109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 26.054620 54.85645 15.279388 2.734686 0.4198225 -1.843394 0.24806667 0.24733333 0.26363333 0.016300000 0.6914776625 0.0001722864 FALSE  
ENST00000473985 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding retained_intron 109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 6.366334 10.35201 4.085439 1.182661 0.5151605 -1.339215 0.06437917 0.04623333 0.07033333 0.024100000 0.0805121563 0.0001722864 FALSE  
MSTRG.21713.1 ENSG00000161179 HEK293_OSMI2_2hA HEK293_TMG_2hB YDJC protein_coding   109.2717 222.7167 57.99405 16.79052 0.7794173 -1.941049 6.536531 19.35951 1.180787 1.159233 0.3330777 -4.023800 0.04755833 0.08730000 0.02043333 -0.066866667 0.0001789356 0.0001722864 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161179 E001 8.368196 0.0022550012 3.085675e-01 4.508533e-01 22 21627925 21628088 164 - 0.945 0.836 -0.418
ENSG00000161179 E002 46.873426 0.0090023759 3.392826e-02 7.960871e-02 22 21628089 21628101 13 - 1.668 1.537 -0.447
ENSG00000161179 E003 105.193390 0.0085980078 4.194805e-05 2.405974e-04 22 21628102 21628106 5 - 2.075 1.861 -0.720
ENSG00000161179 E004 190.383679 0.0038063339 7.579496e-01 8.426313e-01 22 21628107 21628113 7 - 2.123 2.167 0.148
ENSG00000161179 E005 443.730415 0.0076641468 1.270538e-01 2.300353e-01 22 21628114 21628121 8 - 2.435 2.542 0.357
ENSG00000161179 E006 1191.722773 0.0050671902 5.731918e-03 1.790546e-02 22 21628122 21628166 45 - 2.840 2.973 0.445
ENSG00000161179 E007 1679.616785 0.0047353559 5.952780e-03 1.848384e-02 22 21628167 21628255 89 - 2.995 3.121 0.418
ENSG00000161179 E008 2427.933497 0.0044190056 1.146340e-02 3.226521e-02 22 21628256 21628360 105 - 3.168 3.279 0.368
ENSG00000161179 E009 4490.702345 0.0013310462 5.732054e-03 1.790559e-02 22 21628361 21628787 427 - 3.465 3.541 0.252
ENSG00000161179 E010 820.235718 0.0082561546 2.523536e-02 6.235933e-02 22 21629010 21629176 167 - 2.843 2.779 -0.212
ENSG00000161179 E011 401.988106 0.0035088466 2.865618e-02 6.932128e-02 22 21629177 21629187 11 - 2.517 2.472 -0.152
ENSG00000161179 E012 200.798758 0.0006284209 6.723040e-08 7.060198e-07 22 21629188 21629307 120 - 2.295 2.150 -0.483
ENSG00000161179 E013 1488.484922 0.0024692051 7.335129e-01 8.247090e-01 22 21629308 21629407 100 - 3.027 3.053 0.088
ENSG00000161179 E014 635.707873 0.0001150365 1.117050e-12 2.718328e-11 22 21629408 21629542 135 - 2.756 2.658 -0.324
ENSG00000161179 E015 1064.112477 0.0015105828 1.243068e-04 6.336147e-04 22 21629543 21629601 59 - 2.946 2.893 -0.176
ENSG00000161179 E016 1785.153140 0.0047722322 6.500555e-02 1.350453e-01 22 21629602 21629755 154 - 3.148 3.124 -0.079
ENSG00000161179 E017 634.325379 0.0078073124 4.348699e-01 5.771237e-01 22 21629756 21629761 6 - 2.675 2.679 0.013
ENSG00000161179 E018 287.902691 0.0072239746 2.632861e-03 9.168722e-03 22 21629762 21629850 89 - 2.424 2.315 -0.362
ENSG00000161179 E019 1174.372859 0.0099485259 1.265184e-01 2.292996e-01 22 21629851 21630773 923 - 2.972 2.941 -0.104