ENSG00000161091

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355415 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding protein_coding 95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 20.778098 25.845148 14.097010 7.0880390 0.5159491 -0.8740393 0.21583333 0.18083333 0.27280000 0.09196667 3.708528e-01 1.380614e-24 FALSE TRUE
ENST00000398558 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding protein_coding 95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 9.759487 9.674297 4.881090 0.3972202 0.5332292 -0.9854911 0.10785417 0.06906667 0.09386667 0.02480000 1.087629e-01 1.380614e-24 FALSE TRUE
ENST00000585788 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding retained_intron 95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 12.431131 19.165810 6.303223 0.8759879 0.4811902 -1.6028390 0.12496667 0.13663333 0.12160000 -0.01503333 4.945339e-01 1.380614e-24 FALSE FALSE
ENST00000615073 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding protein_coding 95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 11.687438 18.918806 5.112345 2.1005422 0.7389482 -1.8857071 0.11698333 0.13396667 0.09973333 -0.03423333 4.105361e-01 1.380614e-24 FALSE TRUE
MSTRG.16173.10 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding   95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 7.023016 10.513964 7.500794 0.2873531 0.4710463 -0.4866409 0.08255833 0.07540000 0.14553333 0.07013333 9.190601e-05 1.380614e-24 FALSE TRUE
MSTRG.16173.23 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding   95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 5.112033 5.299433 3.453531 0.5031196 0.1047506 -0.6163140 0.05710833 0.03756667 0.06686667 0.02930000 4.627984e-05 1.380614e-24 TRUE TRUE
MSTRG.16173.30 ENSG00000161091 HEK293_OSMI2_2hA HEK293_TMG_2hB MFSD12 protein_coding   95.39539 140.4825 51.72706 7.632135 2.113134 -1.441223 11.505963 32.402586 0.000000 5.7022440 0.0000000 -11.6623384 0.10700417 0.23406667 0.00000000 -0.23406667 1.380614e-24 1.380614e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161091 E001 1.6209171 0.0089120009 4.818939e-02 1.059690e-01 19 3538261 3538274 14 - 0.001 0.426 10.325
ENSG00000161091 E002 61.7664886 0.0004090448 2.620951e-06 1.988272e-05 19 3538275 3538460 186 - 1.877 1.645 -0.785
ENSG00000161091 E003 32.0063689 0.0006179617 4.526213e-08 4.924636e-07 19 3538461 3538461 1 - 1.680 1.326 -1.216
ENSG00000161091 E004 98.3105613 0.0006315068 5.551317e-02 1.188608e-01 19 3538462 3538470 9 - 1.966 1.884 -0.278
ENSG00000161091 E005 482.4868770 0.0001441243 1.489535e-03 5.602413e-03 19 3538471 3538649 179 - 2.642 2.579 -0.207
ENSG00000161091 E006 283.2192323 0.0004752782 2.217571e-01 3.524906e-01 19 3538650 3538670 21 - 2.389 2.355 -0.111
ENSG00000161091 E007 272.3472945 0.0006548071 2.683122e-01 4.067604e-01 19 3538671 3538684 14 - 2.371 2.340 -0.104
ENSG00000161091 E008 218.5990307 0.0007273049 2.039716e-01 3.311466e-01 19 3538685 3538688 4 - 2.282 2.243 -0.132
ENSG00000161091 E009 280.0849107 0.0003610779 5.378550e-01 6.693491e-01 19 3538689 3538710 22 - 2.372 2.355 -0.058
ENSG00000161091 E010 206.8580796 0.0004971609 6.563937e-01 7.659879e-01 19 3538711 3538720 10 - 2.237 2.222 -0.050
ENSG00000161091 E011 192.7384297 0.0005933930 6.256195e-01 7.417112e-01 19 3538721 3538721 1 - 2.209 2.192 -0.056
ENSG00000161091 E012 207.6064433 0.0007680217 7.941962e-01 8.684851e-01 19 3538722 3538728 7 - 2.236 2.227 -0.030
ENSG00000161091 E013 201.2873610 0.0004110037 7.553284e-01 8.407002e-01 19 3538729 3538730 2 - 2.224 2.213 -0.036
ENSG00000161091 E014 256.1666697 0.0013969542 8.312127e-01 8.942031e-01 19 3538731 3538756 26 - 2.324 2.318 -0.020
ENSG00000161091 E015 511.1277615 0.0002107700 1.926845e-03 6.998990e-03 19 3538757 3540043 1287 - 2.570 2.631 0.202
ENSG00000161091 E016 189.5932293 0.0002211643 1.138057e-06 9.337119e-06 19 3542776 3542977 202 - 2.297 2.153 -0.483
ENSG00000161091 E017 202.6706415 0.0036404807 5.523296e-07 4.846558e-06 19 3542978 3543679 702 - 2.367 2.168 -0.663
ENSG00000161091 E018 88.8868439 0.0003003577 1.771370e-11 3.538762e-10 19 3543680 3543857 178 - 2.062 1.788 -0.922
ENSG00000161091 E019 54.7362089 0.0004999562 7.941228e-05 4.251037e-04 19 3543858 3543981 124 - 1.810 1.601 -0.707
ENSG00000161091 E020 48.8961940 0.0004705369 2.331673e-03 8.248896e-03 19 3543982 3544066 85 - 1.739 1.567 -0.582
ENSG00000161091 E021 41.6215082 0.0005816833 1.834473e-02 4.788638e-02 19 3544067 3544138 72 - 1.654 1.509 -0.493
ENSG00000161091 E022 35.8948902 0.0103967700 2.047778e-01 3.321148e-01 19 3544139 3544183 45 - 1.562 1.458 -0.355
ENSG00000161091 E023 27.9696938 0.0107852311 5.671661e-01 6.940272e-01 19 3544184 3544195 12 - 1.418 1.366 -0.180
ENSG00000161091 E024 26.7338667 0.0279131277 7.249316e-01 8.183102e-01 19 3544196 3544198 3 - 1.388 1.351 -0.129
ENSG00000161091 E025 27.2132888 0.0231481893 8.737611e-01 9.228695e-01 19 3544199 3544199 1 - 1.378 1.363 -0.054
ENSG00000161091 E026 284.4592595 0.0056025528 5.634514e-04 2.397331e-03 19 3544200 3544307 108 - 2.238 2.397 0.529
ENSG00000161091 E027 220.0811659 0.0047187293 2.541579e-03 8.887271e-03 19 3544308 3544309 2 - 2.144 2.283 0.464
ENSG00000161091 E028 329.2422104 0.0027552312 1.993013e-06 1.550979e-05 19 3544310 3544354 45 - 2.290 2.462 0.575
ENSG00000161091 E029 272.5916115 0.0036530549 6.666350e-06 4.614080e-05 19 3544355 3544356 2 - 2.196 2.382 0.621
ENSG00000161091 E030 795.3686115 0.0012695246 7.030690e-13 1.768849e-11 19 3544357 3544675 319 - 2.675 2.843 0.559
ENSG00000161091 E031 346.6905983 0.0001515099 1.264181e-10 2.194387e-09 19 3544676 3544732 57 - 2.322 2.479 0.523
ENSG00000161091 E032 22.6486341 0.0064520322 1.612257e-01 2.766965e-01 19 3544733 3544808 76 - 1.389 1.264 -0.435
ENSG00000161091 E033 431.3182171 0.0001264156 1.133094e-05 7.434927e-05 19 3544809 3544833 25 - 2.469 2.562 0.308
ENSG00000161091 E034 664.3825140 0.0001151378 2.153782e-10 3.585794e-09 19 3544834 3544939 106 - 2.642 2.752 0.365
ENSG00000161091 E035 619.7163315 0.0001104358 1.170952e-07 1.174529e-06 19 3546074 3546168 95 - 2.626 2.719 0.311
ENSG00000161091 E036 668.8905616 0.0001097064 6.299813e-06 4.385056e-05 19 3546255 3546425 171 - 2.673 2.749 0.252
ENSG00000161091 E037 442.6063142 0.0001217468 1.536621e-01 2.666511e-01 19 3547272 3547290 19 - 2.579 2.549 -0.101
ENSG00000161091 E038 495.1611568 0.0001099216 6.983524e-03 2.118066e-02 19 3547291 3547326 36 - 2.645 2.593 -0.174
ENSG00000161091 E039 520.3343216 0.0001087742 1.040642e-04 5.407795e-04 19 3547327 3547361 35 - 2.682 2.609 -0.240
ENSG00000161091 E040 370.5403772 0.0001605969 2.675232e-04 1.247405e-03 19 3547362 3547364 3 - 2.541 2.461 -0.268
ENSG00000161091 E041 559.3037457 0.0001477532 2.325224e-02 5.827271e-02 19 3547455 3547521 67 - 2.690 2.648 -0.141
ENSG00000161091 E042 329.0774336 0.0002432243 4.918999e-01 6.291483e-01 19 3547522 3547547 26 - 2.442 2.424 -0.061
ENSG00000161091 E043 420.5397076 0.0001523511 8.462085e-01 9.043923e-01 19 3547848 3547918 71 - 2.530 2.533 0.008
ENSG00000161091 E044 464.2582544 0.0026867627 6.848783e-01 7.877180e-01 19 3547919 3548030 112 - 2.566 2.580 0.047
ENSG00000161091 E045 515.8795836 0.0019908961 9.702622e-01 9.853878e-01 19 3548123 3548267 145 - 2.621 2.623 0.005
ENSG00000161091 E046 243.0520251 0.0004427742 1.366332e-01 2.433875e-01 19 3550984 3550987 4 - 2.330 2.287 -0.145
ENSG00000161091 E047 539.4676041 0.0032430335 8.864164e-03 2.594258e-02 19 3550988 3551194 207 - 2.705 2.624 -0.271
ENSG00000161091 E048 5.3974015 0.1865065813 4.964088e-01 6.330761e-01 19 3556986 3557105 120 - 0.828 0.705 -0.494
ENSG00000161091 E049 159.5553557 0.0111519923 7.620026e-03 2.282466e-02 19 3557106 3557132 27 - 2.231 2.077 -0.516
ENSG00000161091 E050 233.6927868 0.0242369664 5.582842e-04 2.378511e-03 19 3557133 3557600 468 - 2.476 2.210 -0.886
ENSG00000161091 E051 0.7696683 0.0162988013 9.674180e-02 1.854931e-01 19 3567145 3567242 98 - 0.434 0.137 -2.213
ENSG00000161091 E052 2.3165927 0.0063461732 1.046497e-02 2.989740e-02 19 3571572 3571655 84 - 0.746 0.325 -2.041
ENSG00000161091 E053 4.3898780 0.0037103750 2.562910e-01 3.932404e-01 19 3572861 3573021 161 - 0.789 0.618 -0.710
ENSG00000161091 E054 55.7130374 0.0092628013 9.325402e-04 3.728173e-03 19 3573556 3573738 183 - 1.828 1.601 -0.770
ENSG00000161091 E055 34.2603830 0.0047337889 1.975518e-04 9.533725e-04 19 3573739 3573851 113 - 1.648 1.382 -0.913
ENSG00000161091 E056 0.4417591 0.1393497057 7.074727e-01 8.053870e-01 19 3574243 3574290 48 - 0.196 0.135 -0.648