ENSG00000161036

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292616 ENSG00000161036 HEK293_OSMI2_2hA HEK293_TMG_2hB LRWD1 protein_coding protein_coding 74.04707 126.0438 42.5921 7.614404 1.091033 -1.565043 62.105121 109.943421 32.924637 5.133137 0.9665986 -1.7392149 0.82140833 0.8739 0.7728667 -0.1010333 0.00147657 5.234602e-07 FALSE TRUE
ENST00000463739 ENSG00000161036 HEK293_OSMI2_2hA HEK293_TMG_2hB LRWD1 protein_coding protein_coding 74.04707 126.0438 42.5921 7.614404 1.091033 -1.565043 5.278832 3.778115 5.963458 3.778115 0.2420112 0.6570864 0.08800833 0.0289 0.1402667 0.1113667 0.07732055 5.234602e-07 FALSE FALSE
MSTRG.30402.1 ENSG00000161036 HEK293_OSMI2_2hA HEK293_TMG_2hB LRWD1 protein_coding   74.04707 126.0438 42.5921 7.614404 1.091033 -1.565043 2.158547 7.412383 0.000000 4.389073 0.0000000 -9.5357386 0.01790000 0.0583 0.0000000 -0.0583000 0.24280202 5.234602e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161036 E001 22.6721042 1.914884e-02 2.118040e-04 1.014426e-03 7 102464956 102464983 28 + 1.532 1.162 -1.290
ENSG00000161036 E002 61.0396733 1.996884e-02 7.213086e-06 4.950898e-05 7 102464984 102465000 17 + 1.952 1.583 -1.249
ENSG00000161036 E003 142.4299529 2.814310e-02 1.227738e-02 3.419905e-02 7 102465001 102465022 22 + 2.206 1.997 -0.697
ENSG00000161036 E004 265.0738260 1.289720e-02 7.351091e-02 1.491403e-01 7 102465023 102465080 58 + 2.396 2.291 -0.352
ENSG00000161036 E005 256.2778318 7.763108e-03 1.468055e-01 2.573290e-01 7 102465081 102465094 14 + 2.356 2.282 -0.247
ENSG00000161036 E006 347.2606450 4.463806e-03 6.352406e-02 1.325663e-01 7 102465095 102465151 57 + 2.487 2.414 -0.246
ENSG00000161036 E007 255.6810089 5.736342e-03 9.511749e-02 1.830547e-01 7 102465152 102465160 9 + 2.357 2.281 -0.254
ENSG00000161036 E008 20.7718779 3.010579e-03 5.751881e-01 7.008648e-01 7 102465161 102465178 18 + 1.267 1.208 -0.205
ENSG00000161036 E009 0.2214452 3.792200e-02 1.000000e+00   7 102465532 102465627 96 + 0.000 0.068 7.470
ENSG00000161036 E010 0.0000000       7 102465628 102465741 114 +      
ENSG00000161036 E011 0.1482932 4.184695e-02 1.000000e+00   7 102465742 102465816 75 + 0.000 0.068 7.420
ENSG00000161036 E012 919.2788218 2.255668e-03 4.866544e-02 1.068001e-01 7 102465817 102466051 235 + 2.894 2.841 -0.176
ENSG00000161036 E013 857.9903019 2.920878e-04 6.359442e-03 1.955556e-02 7 102466154 102466270 117 + 2.861 2.811 -0.166
ENSG00000161036 E014 404.6810873 2.107247e-03 6.021977e-01 7.232076e-01 7 102467339 102467341 3 + 2.514 2.493 -0.069
ENSG00000161036 E015 902.8282017 6.672105e-04 9.465466e-01 9.704589e-01 7 102467342 102467479 138 + 2.847 2.843 -0.011
ENSG00000161036 E016 1.9153280 8.784399e-02 7.434125e-01 8.320568e-01 7 102467665 102467718 54 + 0.352 0.425 0.413
ENSG00000161036 E017 789.7224901 2.022337e-04 6.375592e-02 1.329485e-01 7 102467719 102467823 105 + 2.764 2.789 0.083
ENSG00000161036 E018 16.0522307 1.254461e-02 4.027779e-05 2.319867e-04 7 102467824 102468061 238 + 1.425 1.004 -1.494
ENSG00000161036 E019 792.7393349 1.289643e-04 9.364818e-01 9.640685e-01 7 102468062 102468187 126 + 2.789 2.784 -0.017
ENSG00000161036 E020 19.2909914 7.115129e-03 1.915645e-08 2.242281e-07 7 102468188 102468262 75 + 1.556 1.055 -1.754
ENSG00000161036 E021 676.4519717 1.349075e-04 1.212362e-01 2.216930e-01 7 102468263 102468377 115 + 2.698 2.718 0.069
ENSG00000161036 E022 45.7849150 6.036162e-04 5.295453e-21 3.821744e-19 7 102468378 102468553 176 + 1.921 1.406 -1.752
ENSG00000161036 E023 644.1614546 3.416579e-04 2.449508e-01 3.799748e-01 7 102468554 102468654 101 + 2.680 2.697 0.056
ENSG00000161036 E024 23.7624753 9.394969e-03 1.761046e-07 1.705998e-06 7 102468655 102468854 200 + 1.606 1.152 -1.576
ENSG00000161036 E025 797.6701195 1.065289e-04 5.508021e-03 1.730908e-02 7 102468855 102469062 208 + 2.756 2.795 0.127
ENSG00000161036 E026 371.9544734 2.486321e-04 5.040405e-01 6.399464e-01 7 102469574 102469588 15 + 2.451 2.460 0.031
ENSG00000161036 E027 537.3725917 1.211081e-04 4.015932e-02 9.133328e-02 7 102469589 102469646 58 + 2.588 2.622 0.112
ENSG00000161036 E028 709.9142386 1.265786e-03 1.914980e-03 6.962084e-03 7 102469742 102469882 141 + 2.679 2.750 0.236
ENSG00000161036 E029 59.0837952 4.226292e-04 5.808898e-27 7.470999e-25 7 102469883 102471468 1586 + 2.032 1.513 -1.757
ENSG00000161036 E030 38.2805619 3.925104e-03 2.268322e-07 2.152401e-06 7 102471469 102472217 749 + 1.747 1.397 -1.198
ENSG00000161036 E031 657.5137346 9.926175e-05 7.524292e-09 9.487218e-08 7 102472218 102472309 92 + 2.621 2.720 0.329
ENSG00000161036 E032 10.5770205 3.053578e-02 8.183651e-04 3.325329e-03 7 102472310 102472453 144 + 1.281 0.834 -1.637
ENSG00000161036 E033 762.1830281 6.544396e-04 3.041507e-06 2.272637e-05 7 102472454 102472609 156 + 2.695 2.785 0.299
ENSG00000161036 E034 6.6120834 6.515890e-03 3.105372e-01 4.529452e-01 7 102472610 102472691 82 + 0.896 0.747 -0.580
ENSG00000161036 E035 670.7973631 2.979822e-03 6.034838e-03 1.870216e-02 7 102472692 102472804 113 + 2.646 2.730 0.279
ENSG00000161036 E036 11.4304767 2.069091e-03 5.709053e-01 6.973212e-01 7 102472805 102472881 77 + 0.929 0.993 0.238
ENSG00000161036 E037 17.7251979 1.122143e-03 4.864440e-01 6.241879e-01 7 102472882 102472908 27 + 1.109 1.174 0.232
ENSG00000161036 E038 747.1696590 6.301120e-03 1.512897e-01 2.634269e-01 7 102472909 102473168 260 + 2.716 2.773 0.189