ENSG00000160963

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313669 ENSG00000160963 HEK293_OSMI2_2hA HEK293_TMG_2hB COL26A1 protein_coding protein_coding 3.436709 5.864691 2.14372 0.2411355 0.04194018 -1.447682 1.5997408 2.211994 1.3623584 0.4808758 0.1884357 -0.6951979 0.4873375 0.3757 0.6374 0.2617 2.178214e-01 3.055587e-09 FALSE TRUE
ENST00000613091 ENSG00000160963 HEK293_OSMI2_2hA HEK293_TMG_2hB COL26A1 protein_coding retained_intron 3.436709 5.864691 2.14372 0.2411355 0.04194018 -1.447682 0.7010485 1.703818 0.0000000 0.2690161 0.0000000 -7.4210698 0.1509667 0.2944 0.0000 -0.2944 3.055587e-09 3.055587e-09 FALSE FALSE
ENST00000613501 ENSG00000160963 HEK293_OSMI2_2hA HEK293_TMG_2hB COL26A1 protein_coding protein_coding 3.436709 5.864691 2.14372 0.2411355 0.04194018 -1.447682 1.1359202 1.948879 0.7813617 0.3824380 0.2092371 -1.3076189 0.3617000 0.3299 0.3626 0.0327 9.442682e-01 3.055587e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160963 E001 0.7696683 0.0163642136 0.124936471 0.22703487 7 101362875 101362876 2 + 0.416 0.145 -2.018
ENSG00000160963 E002 18.2413284 0.0011216923 0.009642589 0.02788627 7 101362877 101363190 314 + 1.360 1.149 -0.745
ENSG00000160963 E003 22.4463804 0.0008387808 0.009298228 0.02702839 7 101419977 101420099 123 + 1.435 1.242 -0.671
ENSG00000160963 E004 8.7376630 0.0370053634 0.056643731 0.12083626 7 101447684 101447689 6 + 1.105 0.844 -0.972
ENSG00000160963 E005 29.8991285 0.0006844865 0.156762301 0.27077826 7 101447690 101447787 98 + 1.483 1.391 -0.318
ENSG00000160963 E006 23.8473423 0.0008539901 0.707246736 0.80521509 7 101533082 101533143 62 + 1.339 1.314 -0.088
ENSG00000160963 E007 29.9033142 0.0006860742 0.836207317 0.89758216 7 101539893 101540049 157 + 1.399 1.418 0.065
ENSG00000160963 E008 19.6386396 0.0009994825 0.267970982 0.40636120 7 101543998 101544096 99 + 1.157 1.261 0.367
ENSG00000160963 E009 24.8402741 0.0073180414 0.255629960 0.39253588 7 101545338 101545490 153 + 1.245 1.354 0.381
ENSG00000160963 E010 24.2278788 0.0008899009 0.482421327 0.62056203 7 101547156 101547239 84 + 1.360 1.310 -0.174
ENSG00000160963 E011 18.6051198 0.0010715620 0.826839484 0.89107506 7 101549171 101549223 53 + 1.203 1.227 0.083
ENSG00000160963 E012 18.1156708 0.0010765585 0.325382926 0.46882729 7 101551108 101551143 36 + 1.271 1.189 -0.287
ENSG00000160963 E013 0.4031496 0.0243467250 0.640464935 0.75369855 7 101553203 101553325 123 + 0.001 0.145 8.133
ENSG00000160963 E014 27.1386989 0.0007532954 0.700658512 0.80007747 7 101553326 101553376 51 + 1.390 1.366 -0.083
ENSG00000160963 E015 34.0371612 0.0007057753 0.550768147 0.68033894 7 101555787 101555871 85 + 1.435 1.479 0.153
ENSG00000160963 E016 209.4417200 0.0015093211 0.004324332 0.01405369 7 101557370 101559024 1655 + 2.189 2.266 0.259