ENSG00000160961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292530 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding protein_coding 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 1.1597461 0.65944385 1.64100781 0.12587688 0.07455452 1.3023120 0.25611667 0.137200000 0.40170000 0.264500000 0.0003129044 0.0003129044 FALSE TRUE
ENST00000392987 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding retained_intron 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 0.3303991 0.33875542 0.23773825 0.02207447 0.06975333 -0.4933990 0.06696667 0.069333333 0.05876667 -0.010566667 0.8306428560 0.0003129044 FALSE TRUE
ENST00000594592 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding retained_intron 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 1.1210894 1.00773818 0.64380571 0.14703058 0.12616977 -0.6384326 0.22244583 0.206300000 0.15526667 -0.051033333 0.6379072446 0.0003129044   FALSE
ENST00000597007 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding nonsense_mediated_decay 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 0.3262289 0.11087406 0.27657725 0.06339685 0.06971641 1.2454194 0.06761250 0.021666667 0.06796667 0.046300000 0.2646198884 0.0003129044 FALSE TRUE
ENST00000597301 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding retained_intron 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 0.1476174 0.03994806 0.30704106 0.01120154 0.07927067 2.6661691 0.03095417 0.008166667 0.07343333 0.065266667 0.0021220530 0.0003129044 TRUE TRUE
ENST00000601629 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding processed_transcript 4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 0.2686558 0.09461871 0.05487642 0.04812748 0.05487642 -0.6893748 0.05304583 0.019133333 0.01390000 -0.005233333 0.7944168177 0.0003129044 FALSE TRUE
MSTRG.16604.7 ENSG00000160961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF333 protein_coding   4.872742 4.877832 4.113923 0.2231938 0.2049378 -0.2451772 1.0125985 2.04038705 0.45824562 0.43905515 0.23347974 -2.1305589 0.20210000 0.417366667 0.10886667 -0.308500000 0.2343503956 0.0003129044 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160961 E001 0.1515154 0.0427526663 6.175403e-01   19 14689801 14689920 120 + 0.117 0.000 -10.189
ENSG00000160961 E002 0.3030308 0.3265621129 3.665183e-01   19 14690048 14690048 1 + 0.209 0.000 -12.754
ENSG00000160961 E003 0.3030308 0.3265621129 3.665183e-01   19 14690049 14690054 6 + 0.209 0.000 -12.754
ENSG00000160961 E004 0.4804688 0.0208330442 7.261778e-01 8.192674e-01 19 14690055 14690068 14 + 0.208 0.128 -0.838
ENSG00000160961 E005 2.0649586 0.0070097377 3.474783e-01 4.917090e-01 19 14690069 14690073 5 + 0.576 0.376 -1.008
ENSG00000160961 E006 2.3605008 0.0062506910 4.204071e-01 5.636141e-01 19 14690074 14690075 2 + 0.610 0.435 -0.839
ENSG00000160961 E007 5.8132885 0.0030193526 2.102448e-01 3.388386e-01 19 14690076 14690098 23 + 0.773 0.877 0.410
ENSG00000160961 E008 6.4325873 0.0035491523 3.431867e-01 4.872571e-01 19 14690099 14690105 7 + 0.835 0.897 0.236
ENSG00000160961 E009 12.6574062 0.0292365423 2.636588e-01 4.015674e-01 19 14690106 14690150 45 + 1.093 1.163 0.251
ENSG00000160961 E010 16.7925558 0.0120698644 1.150185e-01 2.128669e-01 19 14693451 14693494 44 + 1.198 1.286 0.311
ENSG00000160961 E011 27.0033105 0.0008209409 2.053454e-03 7.392037e-03 19 14695010 14695133 124 + 1.365 1.505 0.484
ENSG00000160961 E012 24.0693972 0.0009172362 4.934576e-03 1.574840e-02 19 14695566 14695661 96 + 1.322 1.455 0.461
ENSG00000160961 E013 25.8955026 0.0008245580 9.031491e-04 3.624669e-03 19 14699199 14699281 83 + 1.335 1.495 0.555
ENSG00000160961 E014 1.1081856 0.0322825947 4.967097e-01 6.333255e-01 19 14699282 14699411 130 + 0.284 0.375 0.572
ENSG00000160961 E015 1.2512699 0.0103540869 2.786208e-01 4.182737e-01 19 14700206 14700355 150 + 0.454 0.227 -1.423
ENSG00000160961 E016 3.4656530 0.0049724965 3.432589e-01 4.873107e-01 19 14701584 14701897 314 + 0.725 0.533 -0.837
ENSG00000160961 E017 28.9256310 0.0006877982 8.474655e-02 1.669958e-01 19 14705054 14705170 117 + 1.448 1.495 0.162
ENSG00000160961 E018 4.0909773 0.0761528742 6.665224e-01 7.739545e-01 19 14706091 14706685 595 + 0.699 0.711 0.050
ENSG00000160961 E019 24.1350766 0.0008214820 1.306581e-02 3.606433e-02 19 14706686 14706773 88 + 1.341 1.450 0.378
ENSG00000160961 E020 8.9841607 0.0018920604 1.316615e-04 6.662092e-04 19 14706774 14707262 489 + 0.773 1.138 1.371
ENSG00000160961 E021 4.0774686 0.0824019873 2.770811e-03 9.586039e-03 19 14707917 14707965 49 + 0.348 0.867 2.373
ENSG00000160961 E022 7.5683036 0.0025212573 8.205757e-03 2.430589e-02 19 14707994 14708327 334 + 0.773 1.027 0.970
ENSG00000160961 E023 28.7657270 0.0091320969 1.641109e-07 1.599626e-06 19 14708328 14709123 796 + 1.254 1.602 1.205
ENSG00000160961 E024 8.5507179 0.0021051413 8.560650e-07 7.214045e-06 19 14709124 14709250 127 + 0.642 1.159 1.987
ENSG00000160961 E025 2.8055838 0.0054361115 6.019261e-02 1.269398e-01 19 14714738 14715381 644 + 0.725 0.376 -1.646
ENSG00000160961 E026 12.2254317 0.0230698655 1.811961e-04 8.831249e-04 19 14715382 14715470 89 + 1.322 0.810 -1.870
ENSG00000160961 E027 14.1957711 0.0014023883 6.163371e-08 6.522720e-07 19 14716112 14716238 127 + 1.393 0.813 -2.105
ENSG00000160961 E028 12.1619544 0.0016499180 3.060448e-04 1.403958e-03 19 14716994 14717089 96 + 1.289 0.877 -1.498
ENSG00000160961 E029 4.2953671 0.0183011302 1.760485e-03 6.473074e-03 19 14717090 14717656 567 + 0.924 0.376 -2.423
ENSG00000160961 E030 9.7973010 0.0128731492 9.473406e-04 3.779447e-03 19 14717657 14717733 77 + 1.214 0.764 -1.677
ENSG00000160961 E031 123.3293349 0.0218363060 3.877872e-05 2.242183e-04 19 14718228 14721899 3672 + 2.227 1.925 -1.011
ENSG00000160961 E032 0.2903454 0.3300793306 3.673588e-01   19 14731175 14733746 2572 + 0.208 0.000 -12.743