ENSG00000160917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292476 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding protein_coding 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 10.698372 21.235840 7.084068 1.6133299 0.27451931 -1.5824953 0.17900833 0.22886667 0.18653333 -0.04233333 4.960511e-01 8.662913e-14 FALSE  
ENST00000436336 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding protein_coding 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 20.336506 36.509658 11.635584 2.9211495 1.31694567 -1.6488903 0.33186667 0.38960000 0.30560000 -0.08400000 2.544741e-01 8.662913e-14 FALSE  
ENST00000440514 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding protein_coding 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 3.477433 4.051611 1.891770 1.0712782 0.06834015 -1.0947092 0.06044583 0.04316667 0.04976667 0.00660000 8.085692e-01 8.662913e-14 FALSE  
ENST00000469897 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding retained_intron 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 4.504357 4.498290 3.687394 1.9443316 0.42048689 -0.2860715 0.08157500 0.04653333 0.09720000 0.05066667 1.835981e-01 8.662913e-14 FALSE  
ENST00000482251 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding retained_intron 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 1.881727 1.521570 2.885209 0.2275013 0.13815651 0.9186558 0.03792500 0.01616667 0.07583333 0.05966667 8.662913e-14 8.662913e-14    
ENST00000484112 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding retained_intron 58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 1.995074 1.602848 2.613231 0.2506387 0.16594703 0.7017342 0.03970417 0.01700000 0.06883333 0.05183333 1.956490e-12 8.662913e-14 FALSE  
MSTRG.30301.4 ENSG00000160917 HEK293_OSMI2_2hA HEK293_TMG_2hB CPSF4 protein_coding   58.62436 93.51126 38.01075 4.092461 0.3758403 -1.298507 7.484964 11.402377 2.986209 0.6388178 0.56009280 -1.9293892 0.12502083 0.12180000 0.07870000 -0.04310000 1.523371e-01 8.662913e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160917 E001 9.9309705 0.0071809477 8.950634e-05 4.726609e-04 7 99438922 99438942 21 + 1.234 0.828 -1.493
ENSG00000160917 E002 9.2280123 0.0068082644 4.583114e-05 2.606530e-04 7 99438943 99438945 3 + 1.220 0.788 -1.602
ENSG00000160917 E003 11.4937049 0.0019984327 3.764054e-08 4.158436e-07 7 99438946 99438953 8 + 1.352 0.840 -1.863
ENSG00000160917 E004 209.8705919 0.0068152800 5.192754e-01 6.533951e-01 7 99438954 99439112 159 + 2.248 2.250 0.007
ENSG00000160917 E005 194.3471311 0.0049566007 8.833872e-02 1.725871e-01 7 99439113 99439160 48 + 2.130 2.240 0.369
ENSG00000160917 E006 183.8433529 0.0012366287 9.613190e-04 3.826029e-03 7 99439161 99439185 25 + 2.071 2.221 0.502
ENSG00000160917 E007 2.1034517 0.0126436945 1.157663e-01 2.139040e-01 7 99439376 99439424 49 + 0.626 0.376 -1.227
ENSG00000160917 E008 3.7482282 0.0054947021 7.686578e-01 8.504882e-01 7 99439425 99439449 25 + 0.567 0.638 0.317
ENSG00000160917 E009 10.1034805 0.0052761648 4.058344e-01 5.494862e-01 7 99439450 99439596 147 + 1.028 0.958 -0.259
ENSG00000160917 E010 1.6681491 0.0085712000 1.007353e-01 1.915810e-01 7 99442997 99443175 179 + 0.567 0.298 -1.448
ENSG00000160917 E011 0.1482932 0.0413501661 1.000000e+00   7 99444785 99444788 4 + 0.000 0.078 13.614
ENSG00000160917 E012 186.3455342 0.0010686779 2.664155e-02 6.524693e-02 7 99444789 99444809 21 + 2.110 2.218 0.361
ENSG00000160917 E013 217.4509335 0.0015871097 4.566760e-01 5.970690e-01 7 99444810 99444839 30 + 2.219 2.275 0.190
ENSG00000160917 E014 11.2617213 0.0017362238 1.034258e-01 1.957081e-01 7 99447773 99448040 268 + 0.840 1.066 0.847
ENSG00000160917 E015 452.7787985 0.0001431829 4.628951e-01 6.027468e-01 7 99448121 99448273 153 + 2.568 2.585 0.056
ENSG00000160917 E016 25.6608770 0.0008773033 1.346306e-12 3.231391e-11 7 99450118 99450275 158 + 1.654 1.193 -1.596
ENSG00000160917 E017 248.0952166 0.0030341548 8.042788e-01 8.754982e-01 7 99450276 99450324 49 + 2.306 2.329 0.076
ENSG00000160917 E018 257.4983323 0.0004378855 1.883828e-01 3.116905e-01 7 99450325 99450371 47 + 2.342 2.338 -0.013
ENSG00000160917 E019 20.4630069 0.0009646364 5.252633e-22 4.191641e-20 7 99450464 99450701 238 + 1.669 0.967 -2.465
ENSG00000160917 E020 323.3818871 0.0001627357 5.141843e-01 6.489329e-01 7 99450702 99450765 64 + 2.423 2.439 0.053
ENSG00000160917 E021 248.9023383 0.0002274043 5.849865e-01 7.087758e-01 7 99450766 99450795 30 + 2.287 2.332 0.151
ENSG00000160917 E022 31.3581550 0.0100545259 1.870973e-12 4.385133e-11 7 99450796 99451079 284 + 1.764 1.248 -1.773
ENSG00000160917 E023 374.7569841 0.0001676510 3.034881e-01 4.454138e-01 7 99452368 99452440 73 + 2.492 2.500 0.029
ENSG00000160917 E024 53.5300722 0.0011936472 6.133752e-39 1.976226e-36 7 99452441 99453264 824 + 2.042 1.419 -2.112
ENSG00000160917 E025 12.9389103 0.0014952578 2.069658e-08 2.406201e-07 7 99453604 99453668 65 + 1.392 0.898 -1.778
ENSG00000160917 E026 28.5348909 0.0215118018 1.312985e-08 1.583643e-07 7 99453687 99453965 279 + 1.717 1.212 -1.740
ENSG00000160917 E027 126.0853767 0.0002452751 3.691494e-03 1.227110e-02 7 99453966 99454040 75 + 2.082 2.010 -0.243
ENSG00000160917 E028 201.4397538 0.0007068497 2.256005e-01 3.571211e-01 7 99454041 99454043 3 + 2.233 2.226 -0.021
ENSG00000160917 E029 430.0442957 0.0002258960 6.603258e-01 7.690121e-01 7 99454044 99454136 93 + 2.540 2.562 0.073
ENSG00000160917 E030 20.2989466 0.0146673305 3.750733e-02 8.642031e-02 7 99456386 99456431 46 + 1.382 1.213 -0.592
ENSG00000160917 E031 1878.7954166 0.0033953681 2.257553e-05 1.382578e-04 7 99456432 99457373 942 + 3.099 3.227 0.427