ENSG00000160908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337673 ENSG00000160908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF394 protein_coding protein_coding 11.96739 13.84781 11.27597 0.4256594 0.048218 -0.2961698 5.2293214 5.6380566 4.4954330 1.0886837 0.1975648 -0.3260888 0.44287917 0.41273333 0.39880000 -0.01393333 9.959585e-01 1.37085e-12 FALSE TRUE
ENST00000426306 ENSG00000160908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF394 protein_coding protein_coding 11.96739 13.84781 11.27597 0.4256594 0.048218 -0.2961698 2.8303289 3.1337716 4.7766257 0.4499119 0.2415643 0.6065126 0.23311667 0.22570000 0.42356667 0.19786667 1.083827e-03 1.37085e-12 FALSE TRUE
ENST00000462024 ENSG00000160908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF394 protein_coding processed_transcript 11.96739 13.84781 11.27597 0.4256594 0.048218 -0.2961698 0.6465721 0.9036115 0.3075333 0.4520206 0.1553279 -1.5246731 0.05452500 0.06373333 0.02723333 -0.03650000 8.894798e-01 1.37085e-12   FALSE
ENST00000481881 ENSG00000160908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF394 protein_coding retained_intron 11.96739 13.84781 11.27597 0.4256594 0.048218 -0.2961698 1.3020992 1.1519644 1.2891679 0.1680399 0.1670900 0.1610220 0.11181250 0.08263333 0.11430000 0.03166667 4.568922e-01 1.37085e-12 FALSE TRUE
ENST00000485576 ENSG00000160908 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF394 protein_coding retained_intron 11.96739 13.84781 11.27597 0.4256594 0.048218 -0.2961698 1.2913100 2.7181179 0.0000000 0.6968595 0.0000000 -8.0917622 0.09877917 0.19360000 0.00000000 -0.19360000 1.370850e-12 1.37085e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160908 E001 9.8387151 0.0017270044 0.5482374358 0.6781004760 7 99473877 99476896 3020 - 1.077 0.986 -0.332
ENSG00000160908 E002 3.1868868 0.0591930580 0.3594850961 0.5038088803 7 99479640 99479856 217 - 0.724 0.535 -0.825
ENSG00000160908 E003 2.6227164 0.0916999685 0.8216716644 0.8875110855 7 99484022 99484134 113 - 0.572 0.507 -0.304
ENSG00000160908 E004 8.5347645 0.0021214107 0.0001695461 0.0008330956 7 99485193 99486518 1326 - 1.189 0.749 -1.647
ENSG00000160908 E005 14.5303839 0.0161885138 0.1065026919 0.2003974401 7 99486519 99486963 445 - 1.077 1.218 0.505
ENSG00000160908 E006 1.8456017 0.0084045120 0.2848249350 0.4250967390 7 99493240 99493241 2 - 0.572 0.372 -1.012
ENSG00000160908 E007 1.3672092 0.0103417400 0.4443366448 0.5859138606 7 99493242 99493248 7 - 0.470 0.319 -0.849
ENSG00000160908 E008 345.9646235 0.0124053202 0.0259211163 0.0637858043 7 99493249 99494578 1330 - 2.593 2.480 -0.376
ENSG00000160908 E009 32.9395626 0.0158532174 0.0609308096 0.1282031929 7 99494579 99494631 53 - 1.627 1.444 -0.625
ENSG00000160908 E010 22.3256083 0.0068866719 0.0925503921 0.1791059118 7 99497862 99498483 622 - 1.446 1.278 -0.585
ENSG00000160908 E011 13.9881458 0.0226569742 0.0009254656 0.0037041108 7 99498484 99498584 101 - 0.883 1.255 1.357
ENSG00000160908 E012 21.3843830 0.0315851917 0.0076357831 0.0228628178 7 99498585 99498715 131 - 1.131 1.409 0.979
ENSG00000160908 E013 62.9745826 0.0006623770 0.0012035261 0.0046524867 7 99498716 99498842 127 - 1.711 1.827 0.395
ENSG00000160908 E014 112.0411026 0.0016493282 0.0853037671 0.1678965099 7 99499638 99499871 234 - 2.017 2.047 0.100
ENSG00000160908 E015 139.6792085 0.0004238142 0.4701040042 0.6093141491 7 99499872 99500128 257 - 2.139 2.128 -0.036
ENSG00000160908 E016 66.9986171 0.0004530136 0.1103507310 0.2060657839 7 99500129 99500196 68 - 1.792 1.829 0.127
ENSG00000160908 E017 54.3516823 0.0004546986 0.0684556035 0.1408126984 7 99500197 99500324 128 - 1.690 1.747 0.191
ENSG00000160908 E018 1.1103491 0.4494878300 0.7299366995 0.8220093446 7 99501553 99501873 321 - 0.337 0.273 -0.426
ENSG00000160908 E019 0.8836053 0.0177747118 0.8988556404 0.9394866951 7 99504636 99504857 222 - 0.251 0.259 0.063