ENSG00000160877

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292431 ENSG00000160877 HEK293_OSMI2_2hA HEK293_TMG_2hB NACC1 protein_coding protein_coding 55.14794 89.84917 39.60939 8.10616 1.538848 -1.181459 41.71660 73.50032 27.01926 4.561492 0.3071437 -1.4434248 0.7424250 0.8227333 0.6847333 -0.1380000 0.05348318 0.02171425 FALSE TRUE
ENST00000585663 ENSG00000160877 HEK293_OSMI2_2hA HEK293_TMG_2hB NACC1 protein_coding protein_coding 55.14794 89.84917 39.60939 8.10616 1.538848 -1.181459 10.16968 13.60269 10.61878 2.579530 1.6265187 -0.3569765 0.2009667 0.1483333 0.2659667 0.1176333 0.02747563 0.02171425   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160877 E001 10.071615 0.0810221727 9.040504e-01 9.429433e-01 19 13116862 13116910 49 + 0.933 0.996 0.237
ENSG00000160877 E002 10.317762 0.0455635476 4.828073e-01 6.209194e-01 19 13116911 13116935 25 + 0.878 1.025 0.549
ENSG00000160877 E003 16.067533 0.0168953060 6.193304e-01 7.367740e-01 19 13117994 13118131 138 + 1.083 1.189 0.379
ENSG00000160877 E004 4.851512 0.0063232350 5.596856e-05 3.115070e-04 19 13118132 13118263 132 + 1.025 0.519 -2.058
ENSG00000160877 E005 26.422572 0.0156292025 7.543262e-45 3.477003e-42 19 13118264 13118360 97 + 1.926 0.520 -5.171
ENSG00000160877 E006 63.909806 0.0088921746 2.184654e-22 1.816043e-20 19 13118361 13118454 94 + 2.089 1.526 -1.904
ENSG00000160877 E007 1303.588277 0.0044960605 5.613037e-07 4.918469e-06 19 13135200 13136153 954 + 3.123 3.029 -0.311
ENSG00000160877 E008 591.738544 0.0013597986 1.843416e-04 8.964260e-04 19 13136232 13136405 174 + 2.735 2.701 -0.112
ENSG00000160877 E009 293.909442 0.0018480432 2.032402e-02 5.216463e-02 19 13137271 13137278 8 + 2.420 2.401 -0.063
ENSG00000160877 E010 373.499719 0.0004437038 4.274613e-04 1.879875e-03 19 13137279 13137314 36 + 2.530 2.502 -0.096
ENSG00000160877 E011 420.150974 0.0014310098 1.209372e-01 2.212894e-01 19 13137315 13137376 62 + 2.554 2.565 0.038
ENSG00000160877 E012 488.461308 0.0001684924 9.144809e-06 6.133442e-05 19 13137478 13137575 98 + 2.649 2.616 -0.108
ENSG00000160877 E013 287.658154 0.0003805263 9.243475e-02 1.789187e-01 19 13138147 13138157 11 + 2.390 2.398 0.024
ENSG00000160877 E014 2053.726389 0.0001073384 6.901592e-03 2.096909e-02 19 13138158 13139081 924 + 3.229 3.255 0.087
ENSG00000160877 E015 354.857138 0.0002242741 8.428083e-01 9.020712e-01 19 13139082 13139159 78 + 2.454 2.498 0.149
ENSG00000160877 E016 3275.685736 0.0058317257 1.704966e-11 3.417438e-10 19 13139160 13141147 1988 + 3.268 3.505 0.789