ENSG00000160867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292408 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding protein_coding 15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 1.6480474 2.6225057 1.2209589 0.50366616 0.6104802 -1.09665409 0.10575000 0.13930000 0.10070000 -0.03860000 7.855272e-01 4.466871e-07 FALSE TRUE
ENST00000426612 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding retained_intron 15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 0.8595217 0.7547551 0.9824167 0.05540452 0.1199799 0.37594817 0.05955000 0.04106667 0.08180000 0.04073333 2.143246e-02 4.466871e-07 FALSE TRUE
ENST00000502906 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding protein_coding 15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 2.8336739 4.7566998 0.9088243 1.16390850 0.5349335 -2.37512986 0.18346250 0.26043333 0.07583333 -0.18460000 3.793820e-01 4.466871e-07 FALSE TRUE
ENST00000508139 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding retained_intron 15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 0.8869441 0.8208780 0.6656753 0.19637920 0.3115197 -0.29830655 0.05787083 0.04330000 0.05740000 0.01410000 9.955509e-01 4.466871e-07 FALSE FALSE
ENST00000509511 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding retained_intron 15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 0.4700798 0.2848005 0.8462118 0.02193710 0.1005627 1.53822901 0.03344583 0.01553333 0.07023333 0.05470000 4.466871e-07 4.466871e-07 FALSE TRUE
MSTRG.27375.1 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding   15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 2.0812800 1.8596689 1.5158728 1.03903104 0.7778650 -0.29314812 0.13899167 0.09760000 0.13220000 0.03460000 9.787190e-01 4.466871e-07 FALSE TRUE
MSTRG.27375.3 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding   15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 1.9407798 2.0388644 1.9781576 1.10207960 0.2278600 -0.04339238 0.12062917 0.10433333 0.16700000 0.06266667 7.266038e-01 4.466871e-07 FALSE TRUE
MSTRG.27375.5 ENSG00000160867 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR4 protein_coding   15.33904 18.57807 11.97293 1.75111 0.4983672 -0.6333958 0.8316598 1.7355639 0.7972860 0.54576588 0.1752634 -1.11254135 0.05525417 0.10070000 0.06566667 -0.03503333 7.925485e-01 4.466871e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160867 E001 0.2934659 0.0290785164 6.122136e-01   5 177086867 177086873 7 + 0.163 0.090 -0.979
ENSG00000160867 E002 1.4631633 0.0122817625 1.801065e-01 3.013046e-01 5 177086874 177086882 9 + 0.516 0.285 -1.297
ENSG00000160867 E003 1.4631633 0.0122817625 1.801065e-01 3.013046e-01 5 177086883 177086883 1 + 0.516 0.285 -1.297
ENSG00000160867 E004 1.6846085 0.0104409243 2.865156e-01 4.269272e-01 5 177086884 177086884 1 + 0.516 0.335 -0.975
ENSG00000160867 E005 10.1122310 0.0175943345 3.055005e-01 4.476149e-01 5 177086885 177086897 13 + 1.078 0.963 -0.419
ENSG00000160867 E006 14.2722077 0.0094967271 7.040517e-02 1.440238e-01 5 177086898 177086904 7 + 1.253 1.078 -0.622
ENSG00000160867 E007 17.3614980 0.0121361153 2.275368e-01 3.594511e-01 5 177086905 177086913 9 + 1.295 1.183 -0.392
ENSG00000160867 E008 17.3614980 0.0121361153 2.275368e-01 3.594511e-01 5 177086914 177086914 1 + 1.295 1.183 -0.392
ENSG00000160867 E009 17.8356241 0.0158934856 1.960921e-01 3.213309e-01 5 177086915 177086915 1 + 1.314 1.191 -0.435
ENSG00000160867 E010 53.5750634 0.0060745098 9.890925e-01 9.972411e-01 5 177086916 177087018 103 + 1.685 1.693 0.026
ENSG00000160867 E011 33.5314051 0.0015471468 7.960312e-01 8.697788e-01 5 177087019 177087033 15 + 1.474 1.498 0.083
ENSG00000160867 E012 13.3120355 0.0013865201 9.368442e-01 9.642948e-01 5 177087034 177087077 44 + 1.110 1.124 0.051
ENSG00000160867 E013 0.1482932 0.0417427198 1.000000e+00   5 177087419 177087635 217 + 0.000 0.090 8.404
ENSG00000160867 E014 1.2836490 0.1117982786 1.507932e-01 2.627556e-01 5 177088239 177088514 276 + 0.516 0.230 -1.707
ENSG00000160867 E015 40.1530313 0.0005638583 4.624228e-01 6.022795e-01 5 177089550 177089557 8 + 1.536 1.587 0.174
ENSG00000160867 E016 43.1157550 0.0006165632 7.287867e-02 1.481241e-01 5 177089558 177089566 9 + 1.518 1.631 0.387
ENSG00000160867 E017 42.8103597 0.0120995906 1.146029e-01 2.122594e-01 5 177089567 177089575 9 + 1.505 1.637 0.450
ENSG00000160867 E018 47.7560210 0.0043971540 7.781289e-02 1.559658e-01 5 177089576 177089597 22 + 1.558 1.679 0.412
ENSG00000160867 E019 41.1240896 0.0030708030 6.028422e-02 1.270968e-01 5 177089598 177089602 5 + 1.487 1.617 0.447
ENSG00000160867 E020 68.7696815 0.0004656300 7.460498e-01 8.339149e-01 5 177089603 177089693 91 + 1.781 1.803 0.074
ENSG00000160867 E021 6.7870889 0.0025338855 1.163949e-03 4.518484e-03 5 177089858 177089940 83 + 1.078 0.694 -1.473
ENSG00000160867 E022 5.6118669 0.0106445309 2.359518e-03 8.336822e-03 5 177090335 177090389 55 + 1.025 0.628 -1.562
ENSG00000160867 E023 109.3816462 0.0002932220 2.168071e-04 1.035911e-03 5 177090390 177090653 264 + 2.080 1.957 -0.411
ENSG00000160867 E024 70.3396637 0.0003515548 2.439472e-04 1.149857e-03 5 177090745 177090825 81 + 1.910 1.759 -0.510
ENSG00000160867 E025 10.4705987 0.0017071127 1.407433e-02 3.839278e-02 5 177090826 177090937 112 + 1.180 0.937 -0.886
ENSG00000160867 E026 100.1206555 0.0002775593 1.298955e-03 4.972783e-03 5 177090938 177091104 167 + 2.036 1.926 -0.371
ENSG00000160867 E027 67.9322278 0.0004644955 5.881531e-02 1.246017e-01 5 177091685 177091777 93 + 1.847 1.769 -0.263
ENSG00000160867 E028 42.8419135 0.0005406592 1.650146e-01 2.817241e-01 5 177091778 177091808 31 + 1.647 1.576 -0.242
ENSG00000160867 E029 105.1195737 0.0016009115 8.020814e-01 8.739147e-01 5 177092321 177092511 191 + 1.969 1.987 0.060
ENSG00000160867 E030 104.4972532 0.0029588622 4.999490e-01 6.362074e-01 5 177092646 177092784 139 + 1.950 1.990 0.135
ENSG00000160867 E031 10.7843073 0.0015863771 5.304202e-08 5.687486e-07 5 177092785 177093068 284 + 1.333 0.802 -1.945
ENSG00000160867 E032 52.4106900 0.0340597859 4.270527e-01 5.698939e-01 5 177093138 177093174 37 + 1.616 1.712 0.325
ENSG00000160867 E033 35.0267959 0.0334985497 4.239297e-01 5.669604e-01 5 177093175 177093177 3 + 1.440 1.541 0.347
ENSG00000160867 E034 69.6258810 0.0029107959 7.737443e-01 8.540373e-01 5 177093178 177093331 154 + 1.784 1.808 0.083
ENSG00000160867 E035 18.6412953 0.0010328475 5.092713e-01 6.445918e-01 5 177093332 177093405 74 + 1.285 1.237 -0.169
ENSG00000160867 E036 39.3021649 0.0005627826 5.240344e-01 6.576582e-01 5 177093406 177093417 12 + 1.585 1.554 -0.105
ENSG00000160867 E037 83.8199850 0.0040919376 5.379210e-01 6.694049e-01 5 177093418 177093501 84 + 1.898 1.877 -0.070
ENSG00000160867 E038 80.8035352 0.0008151348 6.113032e-01 7.304201e-01 5 177093502 177093551 50 + 1.845 1.875 0.101
ENSG00000160867 E039 126.4777489 0.0011901905 4.113875e-01 5.549544e-01 5 177093654 177093775 122 + 2.076 2.055 -0.071
ENSG00000160867 E040 0.6955713 0.0173144833 4.981856e-01 6.346821e-01 5 177094825 177095329 505 + 0.282 0.166 -0.974
ENSG00000160867 E041 128.5929588 0.0031971179 6.342278e-01 7.487633e-01 5 177095330 177095440 111 + 2.075 2.066 -0.029
ENSG00000160867 E042 149.6095477 0.0002845443 8.495705e-01 9.066453e-01 5 177095533 177095723 191 + 2.134 2.135 0.005
ENSG00000160867 E043 100.8075389 0.0060347104 3.058255e-01 4.479626e-01 5 177096057 177096179 123 + 1.925 1.986 0.208
ENSG00000160867 E044 92.1898218 0.0038411982 2.824242e-02 6.848916e-02 5 177096287 177096357 71 + 1.842 1.961 0.400
ENSG00000160867 E045 129.9637807 0.0013536391 1.705777e-02 4.506404e-02 5 177096604 177096741 138 + 2.004 2.102 0.328
ENSG00000160867 E046 0.5169874 0.0200785953 1.000000e+00 1.000000e+00 5 177097191 177097291 101 + 0.163 0.166 0.024
ENSG00000160867 E047 133.1386832 0.0009740437 1.967690e-01 3.222059e-01 5 177097292 177097397 106 + 2.047 2.101 0.180
ENSG00000160867 E048 280.5408952 0.0030836733 1.007480e-02 2.894548e-02 5 177097527 177098144 618 + 2.338 2.435 0.323