ENSG00000160818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368232 ENSG00000160818 HEK293_OSMI2_2hA HEK293_TMG_2hB GPATCH4 protein_coding protein_coding 96.09141 114.1718 93.04166 5.784086 3.411632 -0.2952294 81.44268 104.7773 72.71099 5.732117 1.020693 -0.5270194 0.8415167 0.9173667 0.783 -0.1343667 4.32532e-07 4.32532e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160818 E001 2176.117432 0.0015805724 4.161065e-24 4.166498e-22 1 156594301 156595212 912 - 3.186 3.393 0.689
ENSG00000160818 E002 1181.512266 0.0015259352 2.022838e-03 7.297214e-03 1 156595213 156595444 232 - 3.005 3.092 0.290
ENSG00000160818 E003 1020.381808 0.0010840441 4.009117e-02 9.120019e-02 1 156595445 156595597 153 - 3.007 2.992 -0.048
ENSG00000160818 E004 401.718963 0.0009093763 3.762095e-06 2.755103e-05 1 156595598 156595605 8 - 2.642 2.560 -0.272
ENSG00000160818 E005 543.619346 0.0002052953 6.724502e-04 2.797648e-03 1 156595606 156595666 61 - 2.744 2.714 -0.102
ENSG00000160818 E006 473.309901 0.0003414223 1.243680e-01 2.262102e-01 1 156595667 156595716 50 - 2.667 2.663 -0.013
ENSG00000160818 E007 294.074873 0.0021043462 1.110765e-01 2.071214e-01 1 156595717 156595719 3 - 2.473 2.446 -0.090
ENSG00000160818 E008 556.805060 0.0013746539 8.378175e-01 8.986028e-01 1 156595720 156595824 105 - 2.723 2.741 0.057
ENSG00000160818 E009 333.275314 0.0002599848 1.239538e-01 2.256061e-01 1 156595825 156595849 25 - 2.477 2.535 0.191
ENSG00000160818 E010 15.320408 0.0020504450 4.355460e-01 5.777714e-01 1 156595850 156596079 230 - 1.228 1.184 -0.158
ENSG00000160818 E011 4.921617 0.0061808600 5.430840e-01 6.737453e-01 1 156596080 156596080 1 - 0.800 0.738 -0.246
ENSG00000160818 E012 462.980185 0.0009648951 7.404187e-01 8.298491e-01 1 156596081 156596131 51 - 2.635 2.666 0.101
ENSG00000160818 E013 15.135822 0.0096067477 1.537390e-01 2.667478e-01 1 156596132 156596248 117 - 1.265 1.150 -0.407
ENSG00000160818 E014 9.818743 0.0068778305 2.497195e-01 3.855947e-01 1 156596249 156596293 45 - 1.078 0.973 -0.385
ENSG00000160818 E015 14.191194 0.0061754506 1.100535e-01 2.056206e-01 1 156596294 156596386 93 - 1.238 1.107 -0.467
ENSG00000160818 E016 663.942749 0.0011743355 4.544022e-01 5.950407e-01 1 156596387 156596478 92 - 2.806 2.813 0.021
ENSG00000160818 E017 74.529317 0.0018159536 2.923983e-04 1.348859e-03 1 156596479 156597467 989 - 1.947 1.807 -0.470
ENSG00000160818 E018 26.574423 0.0085450734 4.012496e-03 1.317701e-02 1 156597468 156597763 296 - 1.540 1.333 -0.717
ENSG00000160818 E019 10.060924 0.0241508889 6.774170e-04 2.816456e-03 1 156597764 156597799 36 - 1.228 0.822 -1.496
ENSG00000160818 E020 18.675622 0.0208191456 5.535046e-02 1.185953e-01 1 156597800 156597885 86 - 1.375 1.197 -0.626
ENSG00000160818 E021 14.114483 0.0193032939 1.739075e-01 2.932727e-01 1 156597886 156597922 37 - 1.238 1.108 -0.465
ENSG00000160818 E022 9.201071 0.0067414685 1.293874e-01 2.333238e-01 1 156597923 156597939 17 - 1.079 0.932 -0.540
ENSG00000160818 E023 15.236418 0.0117939703 5.077383e-03 1.614216e-02 1 156597940 156598034 95 - 1.339 1.085 -0.901
ENSG00000160818 E024 675.232766 0.0015562808 1.986137e-01 3.244526e-01 1 156598035 156598121 87 - 2.822 2.814 -0.026
ENSG00000160818 E025 9.693171 0.0033490529 4.283012e-03 1.393566e-02 1 156598122 156598226 105 - 1.165 0.887 -1.022
ENSG00000160818 E026 688.242333 0.0011617143 2.366103e-02 5.911265e-02 1 156598227 156598319 93 - 2.841 2.816 -0.083
ENSG00000160818 E027 619.151137 0.0011532091 1.677351e-04 8.254602e-04 1 156598421 156598494 74 - 2.815 2.759 -0.188
ENSG00000160818 E028 2.729006 0.0561336893 4.420856e-01 5.837451e-01 1 156598967 156598967 1 - 0.644 0.540 -0.464
ENSG00000160818 E029 587.257051 0.0018359710 1.279085e-04 6.496307e-04 1 156598968 156599030 63 - 2.802 2.729 -0.241
ENSG00000160818 E030 511.221797 0.0038456949 2.297236e-04 1.090710e-03 1 156599031 156599104 74 - 2.757 2.656 -0.336
ENSG00000160818 E031 10.034063 0.0016594765 3.676318e-01 5.119993e-01 1 156599105 156599408 304 - 1.079 1.010 -0.252
ENSG00000160818 E032 343.762624 0.0043798418 5.058837e-03 1.609129e-02 1 156601409 156601496 88 - 2.575 2.492 -0.274