ENSG00000160752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447866 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding protein_coding 283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 102.12715 180.187016 60.345131 3.9339333 2.73253260 -1.5780268 0.35172917 0.41433333 0.32173333 -0.09260000 2.416505e-02 6.25311e-11 FALSE  
ENST00000467076 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding protein_coding 283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 52.24478 70.879361 36.454894 13.6927320 3.54075384 -0.9590609 0.18302083 0.15946667 0.19456667 0.03510000 6.121316e-01 6.25311e-11 FALSE  
ENST00000468479 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding processed_transcript 283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 23.75808 29.676251 17.360208 5.8423153 2.25062487 -0.7731799 0.09062083 0.06813333 0.09246667 0.02433333 5.262660e-01 6.25311e-11 FALSE  
ENST00000470171 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding processed_transcript 283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 11.32981 8.741386 14.911451 0.8582717 0.98704272 0.7698044 0.04647500 0.02030000 0.07943333 0.05913333 6.253110e-11 6.25311e-11 FALSE  
ENST00000612683 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding protein_coding 283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 13.23693 32.885752 2.455564 7.4494673 1.26890659 -3.7379116 0.03758333 0.07350000 0.01320000 -0.06030000 3.442494e-01 6.25311e-11 FALSE  
MSTRG.2315.2 ENSG00000160752 HEK293_OSMI2_2hA HEK293_TMG_2hB FDPS protein_coding   283.7939 437.611 187.4805 29.05092 1.885859 -1.222865 16.11528 28.145525 9.306416 0.8530777 0.08223491 -1.5955711 0.05472083 0.06466667 0.04963333 -0.01503333 2.230159e-02 6.25311e-11 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160752 E001 1.103831 0.0176693839 4.952137e-01 6.320605e-01 1 155308748 155308754 7 + 0.192 0.331 1.042
ENSG00000160752 E002 3.449478 0.0055015540 8.876219e-01 9.321720e-01 1 155308755 155308793 39 + 0.576 0.608 0.143
ENSG00000160752 E003 3.305451 0.0049583274 9.856751e-01 9.950718e-01 1 155308794 155308802 9 + 0.576 0.587 0.050
ENSG00000160752 E004 20.291615 0.0073317702 8.191483e-01 8.858007e-01 1 155308803 155308853 51 + 1.232 1.260 0.100
ENSG00000160752 E005 53.993558 0.0016338926 5.396437e-02 1.162013e-01 1 155308854 155308862 9 + 1.738 1.638 -0.339
ENSG00000160752 E006 109.828145 0.0108393526 5.603369e-01 6.883383e-01 1 155308863 155308865 3 + 1.993 1.956 -0.125
ENSG00000160752 E007 342.686027 0.0019925475 3.377894e-01 4.816806e-01 1 155308866 155308888 23 + 2.430 2.465 0.117
ENSG00000160752 E008 381.870825 0.0015978435 2.091454e-01 3.375070e-01 1 155308889 155308892 4 + 2.471 2.513 0.139
ENSG00000160752 E009 545.036598 0.0030445615 6.404526e-01 7.536888e-01 1 155308893 155308913 21 + 2.643 2.661 0.060
ENSG00000160752 E010 545.425140 0.0029276460 6.917905e-01 7.931830e-01 1 155308914 155308915 2 + 2.645 2.661 0.052
ENSG00000160752 E011 1123.228304 0.0018633630 9.173847e-03 2.671767e-02 1 155308916 155308958 43 + 3.016 2.957 -0.197
ENSG00000160752 E012 1164.951219 0.0011921067 7.560714e-06 5.163871e-05 1 155308959 155308965 7 + 3.053 2.967 -0.286
ENSG00000160752 E013 83.639048 0.0021689640 2.995291e-23 2.728120e-21 1 155308966 155308967 2 + 2.144 1.707 -1.472
ENSG00000160752 E014 91.625455 0.0003202618 1.223924e-29 1.995427e-27 1 155308968 155308969 2 + 2.176 1.755 -1.415
ENSG00000160752 E015 219.254707 0.0002013969 3.046143e-10 4.951799e-09 1 155308970 155308983 14 + 2.386 2.229 -0.525
ENSG00000160752 E016 219.811549 0.0001991953 2.881700e-10 4.703855e-09 1 155308984 155308984 1 + 2.387 2.230 -0.525
ENSG00000160752 E017 392.076108 0.0001565947 7.846672e-21 5.552964e-19 1 155308985 155309076 92 + 2.651 2.472 -0.593
ENSG00000160752 E018 72.220892 0.0349115426 5.984173e-06 4.187661e-05 1 155309077 155309752 676 + 2.098 1.628 -1.583
ENSG00000160752 E019 19.551652 0.0054186212 9.013720e-02 1.753368e-01 1 155309753 155309788 36 + 1.343 1.197 -0.512
ENSG00000160752 E020 188.173659 0.0059659958 9.969041e-01 1.000000e+00 1 155309789 155309965 177 + 2.195 2.199 0.015
ENSG00000160752 E021 24.987440 0.0035328089 5.816658e-04 2.465926e-03 1 155309966 155310042 77 + 1.520 1.261 -0.897
ENSG00000160752 E022 951.754128 0.0017406903 8.280198e-01 8.919081e-01 1 155310043 155310063 21 + 2.901 2.899 -0.006
ENSG00000160752 E023 3093.466832 0.0005908380 1.613941e-06 1.281191e-05 1 155310064 155310205 142 + 3.456 3.398 -0.192
ENSG00000160752 E024 13.346326 0.0014733002 8.147225e-01 8.826221e-01 1 155310336 155310453 118 + 1.061 1.096 0.125
ENSG00000160752 E025 2781.314430 0.0006723934 7.562159e-01 8.413483e-01 1 155312255 155312395 141 + 3.358 3.367 0.030
ENSG00000160752 E026 62.803509 0.0036006595 5.924704e-42 2.328667e-39 1 155312396 155312979 584 + 2.151 1.441 -2.401
ENSG00000160752 E027 1809.514728 0.0005503010 1.274199e-05 8.261798e-05 1 155317941 155318021 81 + 3.124 3.195 0.237
ENSG00000160752 E028 1175.022771 0.0001684261 2.601941e-06 1.975196e-05 1 155318169 155318174 6 + 2.936 3.009 0.244
ENSG00000160752 E029 1217.237175 0.0010155432 1.131808e-01 2.101660e-01 1 155318175 155318187 13 + 2.979 3.016 0.122
ENSG00000160752 E030 2191.146217 0.0015812250 4.992868e-02 1.090444e-01 1 155318188 155318291 104 + 3.226 3.272 0.151
ENSG00000160752 E031 71.047276 0.0049789731 4.440340e-04 1.943824e-03 1 155318292 155318332 41 + 1.919 1.728 -0.645
ENSG00000160752 E032 59.674152 0.0006130970 8.348048e-11 1.493120e-09 1 155318333 155318377 45 + 1.922 1.617 -1.032
ENSG00000160752 E033 124.935537 0.0036873544 3.473046e-17 1.579352e-15 1 155318378 155318664 287 + 2.273 1.911 -1.213
ENSG00000160752 E034 1794.481803 0.0004071828 4.928512e-03 1.573064e-02 1 155318665 155318718 54 + 3.141 3.188 0.156
ENSG00000160752 E035 1595.805486 0.0005075216 5.624066e-02 1.201293e-01 1 155318719 155318753 35 + 3.097 3.135 0.124
ENSG00000160752 E036 55.322607 0.0303065044 2.981274e-03 1.020828e-02 1 155318754 155318855 102 + 1.874 1.592 -0.953
ENSG00000160752 E037 2352.272633 0.0004926320 6.245711e-02 1.307798e-01 1 155318856 155318928 73 + 3.268 3.301 0.110
ENSG00000160752 E038 2164.840766 0.0013037528 1.641831e-01 2.806106e-01 1 155319611 155319654 44 + 3.230 3.264 0.113
ENSG00000160752 E039 2064.508083 0.0013897412 3.826320e-01 5.268365e-01 1 155319655 155319688 34 + 3.216 3.242 0.085
ENSG00000160752 E040 59.153235 0.0022648645 1.391881e-03 5.280088e-03 1 155319689 155319793 105 + 1.825 1.661 -0.554
ENSG00000160752 E041 1919.166239 0.0008354381 5.852280e-03 1.822376e-02 1 155319794 155319856 63 + 3.163 3.217 0.180
ENSG00000160752 E042 2102.935263 0.0005935926 4.732935e-02 1.044159e-01 1 155319857 155319928 72 + 3.216 3.253 0.122
ENSG00000160752 E043 2402.752859 0.0006628373 1.421180e-04 7.126100e-04 1 155320409 155320793 385 + 3.253 3.316 0.211