ENSG00000160714

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292211 ENSG00000160714 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Q1 protein_coding protein_coding 76.72097 83.89966 80.30765 6.754739 3.098987 -0.06311998 38.462995 51.750893 41.63735 3.627398 0.6238579 -0.3136377 0.49779167 0.61836667 0.5195000 -0.09886667 1.288345e-02 1.482643e-06 FALSE TRUE
ENST00000491572 ENSG00000160714 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Q1 protein_coding processed_transcript 76.72097 83.89966 80.30765 6.754739 3.098987 -0.06311998 5.898761 2.964657 11.73822 1.483212 1.6381927 1.9816467 0.07837083 0.03273333 0.1454333 0.11270000 3.568520e-01 1.482643e-06   FALSE
ENST00000497453 ENSG00000160714 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Q1 protein_coding processed_transcript 76.72097 83.89966 80.30765 6.754739 3.098987 -0.06311998 14.115920 10.644274 14.95508 2.204254 1.2470252 0.4901676 0.18553750 0.12813333 0.1861333 0.05800000 3.713176e-01 1.482643e-06 FALSE TRUE
MSTRG.2275.3 ENSG00000160714 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Q1 protein_coding   76.72097 83.89966 80.30765 6.754739 3.098987 -0.06311998 12.086375 15.493327 4.05974 1.778805 0.9044689 -1.9295693 0.15531250 0.18406667 0.0498000 -0.13426667 1.482643e-06 1.482643e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160714 E001 1004.1269648 0.0002534093 4.033800e-05 2.322841e-04 1 154548577 154550062 1486 - 3.018 2.963 -0.180
ENSG00000160714 E002 1420.9693619 0.0002969697 1.247180e-13 3.496220e-12 1 154550063 154550408 346 - 3.072 3.161 0.295
ENSG00000160714 E003 729.5489936 0.0001776864 5.536873e-05 3.085039e-04 1 154550409 154550469 61 - 2.804 2.864 0.197
ENSG00000160714 E004 525.5650418 0.0003686927 2.766839e-02 6.735317e-02 1 154550938 154550952 15 - 2.676 2.716 0.133
ENSG00000160714 E005 706.9394174 0.0008687129 1.147679e-02 3.229955e-02 1 154550953 154551004 52 - 2.797 2.845 0.158
ENSG00000160714 E006 8.9916850 0.0182233446 7.274940e-05 3.934049e-04 1 154551223 154551396 174 - 1.235 0.748 -1.815
ENSG00000160714 E007 714.6549363 0.0006730986 3.593619e-01 5.036958e-01 1 154551397 154551459 63 - 2.824 2.840 0.052
ENSG00000160714 E008 581.8637284 0.0001217216 5.373869e-01 6.689555e-01 1 154551460 154551492 33 - 2.740 2.749 0.032
ENSG00000160714 E009 8.4571930 0.0125102785 4.083988e-05 2.349171e-04 1 154551751 154551770 20 - 1.213 0.727 -1.825
ENSG00000160714 E010 642.0877177 0.0004537420 6.202703e-01 7.375007e-01 1 154551771 154551819 49 - 2.794 2.784 -0.033
ENSG00000160714 E011 10.6604641 0.0167749825 1.801231e-03 6.603209e-03 1 154551820 154551857 38 - 1.246 0.883 -1.322
ENSG00000160714 E012 625.4564105 0.0001329847 7.444539e-01 8.327845e-01 1 154551921 154551979 59 - 2.781 2.776 -0.017
ENSG00000160714 E013 12.9446724 0.0067624889 1.751503e-09 2.480727e-08 1 154551980 154552092 113 - 1.420 0.820 -2.173
ENSG00000160714 E014 725.5450017 0.0001201816 5.139804e-02 1.116383e-01 1 154552093 154552183 91 - 2.822 2.850 0.090
ENSG00000160714 E015 19.7939027 0.0027031635 4.061312e-10 6.469924e-09 1 154552184 154552375 192 - 1.560 1.068 -1.720
ENSG00000160714 E016 8.3111070 0.0026877791 2.862765e-09 3.900901e-08 1 154552382 154552403 22 - 1.275 0.609 -2.544
ENSG00000160714 E017 660.6101849 0.0001410270 5.614223e-01 6.892457e-01 1 154552404 154552464 61 - 2.794 2.802 0.026
ENSG00000160714 E018 11.7247377 0.0014829698 2.494351e-09 3.435708e-08 1 154552465 154552735 271 - 1.377 0.803 -2.091
ENSG00000160714 E019 710.1171740 0.0001341949 9.400006e-01 9.663256e-01 1 154552736 154552820 85 - 2.832 2.831 -0.006
ENSG00000160714 E020 911.2790150 0.0001675937 4.925555e-02 1.078416e-01 1 154553032 154553172 141 - 2.957 2.930 -0.088
ENSG00000160714 E021 616.1840871 0.0001528846 2.041093e-03 7.353827e-03 1 154554735 154554785 51 - 2.801 2.753 -0.159
ENSG00000160714 E022 723.7144948 0.0004365372 2.253154e-02 5.678506e-02 1 154555428 154555532 105 - 2.864 2.825 -0.132
ENSG00000160714 E023 5.4038224 0.0837886429 3.421895e-01 4.861861e-01 1 154555844 154555859 16 - 0.883 0.728 -0.611
ENSG00000160714 E024 574.4924929 0.0013140624 7.799021e-02 1.562402e-01 1 154555860 154555964 105 - 2.766 2.721 -0.149
ENSG00000160714 E025 329.1435785 0.0088600760 4.687994e-01 6.081678e-01 1 154558227 154558365 139 - 2.523 2.479 -0.149
ENSG00000160714 E026 148.7362088 0.0114441053 8.796243e-04 3.542639e-03 1 154558366 154558662 297 - 2.277 2.069 -0.696
ENSG00000160714 E027 2.3532105 0.1341016659 9.656801e-01 9.824365e-01 1 154558908 154559041 134 - 0.487 0.493 0.027
ENSG00000160714 E028 0.2998086 0.0285114355 7.212665e-01   1 154559042 154559584 543 - 0.151 0.099 -0.704