ENSG00000160695

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524454 ENSG00000160695 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS11 protein_coding processed_transcript 22.21429 28.76844 16.28472 0.6145983 0.5222386 -0.820584 0.9554608 3.212083 0.000000 1.50495540 0.0000000 -8.3318497 0.03458750 0.10953333 0.00000000 -0.10953333 7.706483e-07 7.706483e-07   FALSE
ENST00000614944 ENSG00000160695 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS11 protein_coding protein_coding 22.21429 28.76844 16.28472 0.6145983 0.5222386 -0.820584 1.3806779 1.005518 1.623967 0.06124533 0.2951946 0.6861627 0.06768750 0.03506667 0.09900000 0.06393333 5.197055e-04 7.706483e-07 FALSE TRUE
ENST00000621676 ENSG00000160695 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS11 protein_coding protein_coding 22.21429 28.76844 16.28472 0.6145983 0.5222386 -0.820584 15.1599583 20.931249 9.960807 1.02335886 0.3450652 -1.0705652 0.67180417 0.72973333 0.61366667 -0.11606667 3.242705e-01 7.706483e-07 FALSE TRUE
ENST00000622309 ENSG00000160695 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS11 protein_coding retained_intron 22.21429 28.76844 16.28472 0.6145983 0.5222386 -0.820584 1.4322688 0.988046 1.534534 0.03382591 0.2254772 0.6299936 0.06850417 0.03430000 0.09373333 0.05943333 3.813566e-05 7.706483e-07 TRUE TRUE
MSTRG.6426.1 ENSG00000160695 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS11 protein_coding   22.21429 28.76844 16.28472 0.6145983 0.5222386 -0.820584 1.7068469 1.328700 1.559902 0.08647884 0.0651832 0.2298414 0.08272083 0.04623333 0.09600000 0.04976667 3.366930e-04 7.706483e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160695 E001 14.011183 0.0015168714 6.254800e-01 7.415875e-01 11 119067807 119067817 11 + 1.171 1.133 -0.135
ENSG00000160695 E002 19.076585 0.0010445384 7.176254e-01 8.129446e-01 11 119067818 119067820 3 + 1.285 1.263 -0.076
ENSG00000160695 E003 19.999755 0.0019094250 9.763499e-01 9.892159e-01 11 119067821 119067822 2 + 1.285 1.296 0.037
ENSG00000160695 E004 111.581595 0.0002774168 7.546460e-05 4.064866e-04 11 119067823 119068010 188 + 2.100 1.972 -0.430
ENSG00000160695 E005 4.431597 0.0267975938 2.168224e-01 3.465803e-01 11 119068011 119068012 2 + 0.832 0.656 -0.714
ENSG00000160695 E006 12.398783 0.0018339343 4.906903e-06 3.499597e-05 11 119068013 119068202 190 + 1.342 0.922 -1.509
ENSG00000160695 E007 5.769375 0.0423615774 3.104746e-04 1.422214e-03 11 119069173 119069195 23 + 1.100 0.558 -2.149
ENSG00000160695 E008 48.674789 0.0005717330 1.013116e-05 6.723360e-05 11 119069196 119069197 2 + 1.802 1.586 -0.734
ENSG00000160695 E009 131.057534 0.0025128572 2.430094e-04 1.145979e-03 11 119069198 119069344 147 + 2.172 2.037 -0.452
ENSG00000160695 E010 117.543305 0.0038639005 5.345762e-03 1.687307e-02 11 119069442 119069552 111 + 2.110 1.996 -0.384
ENSG00000160695 E011 63.037669 0.0062054249 2.108638e-01 3.395685e-01 11 119069553 119069577 25 + 1.811 1.745 -0.222
ENSG00000160695 E012 136.871890 0.0019023734 5.091196e-03 1.617982e-02 11 119070234 119070397 164 + 2.164 2.069 -0.318
ENSG00000160695 E013 1.437139 0.0090114211 5.344537e-01 6.665095e-01 11 119070398 119070784 387 + 0.445 0.340 -0.588
ENSG00000160695 E014 167.292625 0.0003122408 6.889682e-02 1.415451e-01 11 119071596 119071843 248 + 2.219 2.174 -0.150
ENSG00000160695 E015 7.392019 0.0022586899 9.535536e-05 5.002156e-04 11 119072032 119073197 1166 + 1.144 0.702 -1.679
ENSG00000160695 E016 142.452306 0.0007118380 1.828187e-01 3.047305e-01 11 119073198 119073332 135 + 2.144 2.108 -0.119
ENSG00000160695 E017 101.292333 0.0009650718 2.184024e-02 5.534542e-02 11 119073333 119073399 67 + 2.026 1.946 -0.270
ENSG00000160695 E018 17.667096 0.0010647990 4.520411e-05 2.574567e-04 11 119073400 119073799 400 + 1.436 1.118 -1.119
ENSG00000160695 E019 70.830034 0.0075164521 1.356705e-01 2.420550e-01 11 119073800 119073821 22 + 1.873 1.792 -0.272
ENSG00000160695 E020 132.876451 0.0021188492 4.309083e-02 9.672195e-02 11 119073822 119073951 130 + 2.134 2.065 -0.229
ENSG00000160695 E021 3.979418 0.0043882833 1.856706e-02 4.837876e-02 11 119076819 119076896 78 + 0.860 0.529 -1.392
ENSG00000160695 E022 155.213824 0.0056868595 1.384873e-01 2.459917e-01 11 119076897 119077019 123 + 2.195 2.136 -0.196
ENSG00000160695 E023 118.388954 0.0006417133 1.065827e-01 2.005041e-01 11 119077020 119077083 64 + 2.071 2.022 -0.165
ENSG00000160695 E024 180.170175 0.0014464517 3.412767e-01 4.851921e-01 11 119077501 119077647 147 + 2.195 2.234 0.132
ENSG00000160695 E025 212.132889 0.0013585990 2.533858e-01 3.898990e-01 11 119077878 119078066 189 + 2.263 2.307 0.147
ENSG00000160695 E026 1.439215 0.0091320969 5.346333e-01 6.666579e-01 11 119078145 119078172 28 + 0.445 0.340 -0.588
ENSG00000160695 E027 180.147460 0.0002684122 6.083391e-02 1.280425e-01 11 119078173 119078334 162 + 2.178 2.240 0.207
ENSG00000160695 E028 15.795346 0.0020769623 4.609609e-06 3.308618e-05 11 119078335 119078564 230 + 1.422 1.040 -1.350
ENSG00000160695 E029 160.434265 0.0017884174 1.551672e-02 4.166685e-02 11 119078565 119078704 140 + 2.103 2.199 0.321
ENSG00000160695 E030 10.253511 0.0016732768 1.618625e-04 7.999887e-04 11 119078705 119078794 90 + 1.243 0.870 -1.363
ENSG00000160695 E031 223.860564 0.0002190548 5.348803e-02 1.153591e-01 11 119078795 119078997 203 + 2.276 2.333 0.192
ENSG00000160695 E032 149.143047 0.0032533667 2.765393e-01 4.160080e-01 11 119079129 119079181 53 + 2.103 2.158 0.184
ENSG00000160695 E033 202.433024 0.0014819172 8.536108e-05 4.533487e-04 11 119079182 119079300 119 + 2.173 2.310 0.456
ENSG00000160695 E034 289.755300 0.0009602640 4.860248e-10 7.625969e-09 11 119081092 119081314 223 + 2.300 2.475 0.584
ENSG00000160695 E035 374.624197 0.0036061433 3.199367e-07 2.942856e-06 11 119081459 119081972 514 + 2.405 2.588 0.610