ENSG00000160679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368686 ENSG00000160679 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTOP protein_coding protein_coding 118.1816 148.7314 128.7874 17.51176 2.220736 -0.2077032 6.29003 2.648615 9.649951 0.5059644 0.2746661 1.8613410 0.05714167 0.01773333 0.07503333 0.05730000 4.523389e-15 4.523389e-15 FALSE FALSE
ENST00000368690 ENSG00000160679 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTOP protein_coding protein_coding 118.1816 148.7314 128.7874 17.51176 2.220736 -0.2077032 43.84988 64.098724 46.504749 7.9106104 0.6499318 -0.4628325 0.36372500 0.43026667 0.36133333 -0.06893333 6.833281e-03 4.523389e-15 FALSE TRUE
ENST00000368694 ENSG00000160679 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTOP protein_coding protein_coding 118.1816 148.7314 128.7874 17.51176 2.220736 -0.2077032 50.03747 68.599842 47.298842 7.6222867 2.0221479 -0.5363057 0.42170417 0.46200000 0.36693333 -0.09506667 5.540262e-06 4.523389e-15 FALSE TRUE
ENST00000495554 ENSG00000160679 HEK293_OSMI2_2hA HEK293_TMG_2hB CHTOP protein_coding processed_transcript 118.1816 148.7314 128.7874 17.51176 2.220736 -0.2077032 11.08247 6.289984 15.864338 0.5745005 0.3452028 1.3332764 0.09959583 0.04296667 0.12326667 0.08030000 6.448253e-13 4.523389e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160679 E001 18.94622 1.019228e-03 4.041584e-01 5.478669e-01 1 153633982 153634065 84 + 1.334 1.267 -0.236
ENSG00000160679 E002 26.87158 7.066193e-04 9.610205e-03 2.780386e-02 1 153634066 153634074 9 + 1.539 1.365 -0.596
ENSG00000160679 E003 58.33040 3.822160e-04 7.938653e-10 1.199612e-08 1 153634075 153634079 5 + 1.919 1.635 -0.959
ENSG00000160679 E004 969.30805 2.368884e-03 8.298883e-01 8.931947e-01 1 153634080 153634196 117 + 2.986 2.967 -0.065
ENSG00000160679 E005 898.12586 1.482668e-03 7.327470e-01 8.241581e-01 1 153634197 153634236 40 + 2.954 2.935 -0.063
ENSG00000160679 E006 772.38780 1.190997e-03 9.602979e-01 9.789945e-01 1 153634237 153634250 14 + 2.884 2.872 -0.040
ENSG00000160679 E007 726.42485 1.610963e-03 6.202954e-01 7.375037e-01 1 153634251 153634255 5 + 2.864 2.841 -0.078
ENSG00000160679 E008 1144.87319 2.406766e-03 3.991578e-01 5.428868e-01 1 153634256 153634343 88 + 3.042 3.049 0.024
ENSG00000160679 E009 1000.58382 2.060623e-03 2.119106e-01 3.407530e-01 1 153636572 153636653 82 + 2.978 2.995 0.057
ENSG00000160679 E010 534.24960 4.295232e-03 8.807744e-40 2.995692e-37 1 153636654 153638083 1430 + 2.950 2.471 -1.597
ENSG00000160679 E011 147.05280 1.519076e-03 1.147973e-18 6.291003e-17 1 153638084 153638294 211 + 2.326 2.018 -1.031
ENSG00000160679 E012 928.08165 1.764089e-03 7.001303e-01 7.996575e-01 1 153638295 153638341 47 + 2.958 2.955 -0.010
ENSG00000160679 E013 1359.62944 5.148446e-04 1.337693e-02 3.679499e-02 1 153638342 153638448 107 + 3.107 3.133 0.087
ENSG00000160679 E014 17.14138 1.320627e-03 2.860837e-19 1.681070e-17 1 153638550 153638609 60 + 1.571 0.778 -2.858
ENSG00000160679 E015 355.61041 1.543284e-04 3.962038e-04 1.759856e-03 1 153642243 153642245 3 + 2.503 2.571 0.226
ENSG00000160679 E016 610.99560 1.463207e-04 6.884007e-07 5.919902e-06 1 153642246 153642247 2 + 2.733 2.807 0.247
ENSG00000160679 E017 1825.57924 1.273077e-04 1.463662e-10 2.512392e-09 1 153642248 153642429 182 + 3.218 3.274 0.189
ENSG00000160679 E018 113.03738 2.698772e-03 1.099741e-42 4.442273e-40 1 153642430 153643226 797 + 2.318 1.726 -1.985
ENSG00000160679 E019 1375.91756 4.842813e-04 5.831670e-05 3.231710e-04 1 153643227 153643364 138 + 3.098 3.148 0.166
ENSG00000160679 E020 210.31277 1.116672e-02 5.878811e-23 5.189763e-21 1 153643365 153644385 1021 + 2.580 2.005 -1.920
ENSG00000160679 E021 454.95835 4.458513e-03 1.468764e-01 2.574295e-01 1 153645064 153645078 15 + 2.683 2.625 -0.194
ENSG00000160679 E022 888.84245 9.407147e-05 5.621719e-06 3.955645e-05 1 153645079 153645132 54 + 2.908 2.962 0.181
ENSG00000160679 E023 3265.68374 3.399661e-03 4.498817e-02 1.001760e-01 1 153645133 153646306 1174 + 3.473 3.517 0.144