ENSG00000160633

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292123 ENSG00000160633 HEK293_OSMI2_2hA HEK293_TMG_2hB SAFB protein_coding protein_coding 115.3791 142.5612 115.1185 3.140489 1.504666 -0.3084383 11.177505 21.476557 8.140381 1.663529 0.7139151 -1.3984950 0.09422500 0.15110000 0.07086667 -0.08023333 2.358351e-04 5.004428e-06 FALSE TRUE
ENST00000588852 ENSG00000160633 HEK293_OSMI2_2hA HEK293_TMG_2hB SAFB protein_coding protein_coding 115.3791 142.5612 115.1185 3.140489 1.504666 -0.3084383 36.030366 37.004427 42.899526 4.817929 1.9087944 0.2132103 0.31035833 0.25840000 0.37233333 0.11393333 3.305330e-02 5.004428e-06 FALSE TRUE
ENST00000592224 ENSG00000160633 HEK293_OSMI2_2hA HEK293_TMG_2hB SAFB protein_coding protein_coding 115.3791 142.5612 115.1185 3.140489 1.504666 -0.3084383 43.567129 65.186784 34.569335 1.420036 0.8698476 -0.9148907 0.36911250 0.45800000 0.30056667 -0.15743333 5.004428e-06 5.004428e-06 FALSE TRUE
MSTRG.16248.1 ENSG00000160633 HEK293_OSMI2_2hA HEK293_TMG_2hB SAFB protein_coding   115.3791 142.5612 115.1185 3.140489 1.504666 -0.3084383 9.604282 7.682499 13.903123 1.809676 1.7865475 0.8549221 0.08226667 0.05363333 0.12043333 0.06680000 4.759688e-02 5.004428e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160633 E001 4.446081 3.658154e-03 3.557242e-01 5.000675e-01 19 5623034 5623034 1 + 0.799 0.666 -0.543
ENSG00000160633 E002 11.301991 1.581359e-03 2.957206e-01 4.368669e-01 19 5623035 5623082 48 + 1.135 1.026 -0.394
ENSG00000160633 E003 29.439178 7.123480e-04 2.734819e-05 1.642426e-04 19 5623083 5623098 16 + 1.621 1.348 -0.936
ENSG00000160633 E004 30.807620 7.631694e-04 6.765110e-06 4.675775e-05 19 5623099 5623100 2 + 1.646 1.358 -0.986
ENSG00000160633 E005 93.329669 1.299189e-02 1.281725e-04 6.508321e-04 19 5623101 5623117 17 + 2.105 1.843 -0.880
ENSG00000160633 E006 107.185016 1.013155e-02 3.207299e-05 1.894292e-04 19 5623118 5623120 3 + 2.161 1.905 -0.861
ENSG00000160633 E007 156.749397 1.036518e-02 4.695418e-04 2.043588e-03 19 5623121 5623138 18 + 2.299 2.092 -0.693
ENSG00000160633 E008 899.689658 3.705705e-03 6.360111e-10 9.791987e-09 19 5623139 5623394 256 + 3.053 2.852 -0.668
ENSG00000160633 E009 779.658491 1.766117e-03 5.931492e-16 2.308821e-14 19 5626405 5626489 85 + 2.990 2.790 -0.663
ENSG00000160633 E010 815.470806 9.998327e-04 2.021168e-22 1.688290e-20 19 5641594 5641658 65 + 3.008 2.812 -0.653
ENSG00000160633 E011 941.075803 5.924048e-04 4.943099e-17 2.202388e-15 19 5641740 5641850 111 + 3.041 2.898 -0.473
ENSG00000160633 E012 793.204170 1.495737e-03 2.456046e-05 1.492799e-04 19 5641851 5641946 96 + 2.942 2.841 -0.336
ENSG00000160633 E013 657.490601 1.451383e-03 4.121030e-05 2.368320e-04 19 5645337 5645399 63 + 2.860 2.759 -0.339
ENSG00000160633 E014 513.375470 3.751291e-03 4.032391e-03 1.323248e-02 19 5648016 5648043 28 + 2.755 2.650 -0.349
ENSG00000160633 E015 36.595915 5.424173e-04 1.363162e-20 9.350000e-19 19 5648044 5648404 361 + 1.829 1.283 -1.870
ENSG00000160633 E016 7.764490 2.548494e-03 2.912019e-05 1.738047e-04 19 5648855 5648988 134 + 1.172 0.690 -1.830
ENSG00000160633 E017 1048.372906 2.726648e-03 8.745818e-02 1.712837e-01 19 5648989 5649499 511 + 3.034 2.979 -0.182
ENSG00000160633 E018 16.342597 3.269850e-03 2.597517e-03 9.058128e-03 19 5649684 5649925 242 + 1.370 1.104 -0.938
ENSG00000160633 E019 604.767847 2.091251e-03 1.077212e-01 2.021702e-01 19 5649926 5649975 50 + 2.792 2.742 -0.167
ENSG00000160633 E020 777.570349 1.438521e-03 2.508943e-01 3.869986e-01 19 5650978 5651072 95 + 2.891 2.857 -0.111
ENSG00000160633 E021 1268.271868 7.774509e-05 4.138816e-02 9.360324e-02 19 5653115 5653264 150 + 3.100 3.072 -0.091
ENSG00000160633 E022 1191.097890 5.684904e-04 6.649208e-02 1.375429e-01 19 5653338 5653420 83 + 3.077 3.044 -0.110
ENSG00000160633 E023 1518.396819 2.164935e-04 8.482499e-02 1.671278e-01 19 5654061 5654200 140 + 3.151 3.166 0.047
ENSG00000160633 E024 1136.302062 4.526730e-04 4.979875e-03 1.587371e-02 19 5654368 5654456 89 + 3.011 3.047 0.119
ENSG00000160633 E025 991.006001 4.243810e-04 1.489040e-05 9.511250e-05 19 5657241 5657324 84 + 2.935 2.996 0.201
ENSG00000160633 E026 630.686354 7.535454e-04 6.661055e-04 2.774541e-03 19 5657325 5657347 23 + 2.739 2.801 0.208
ENSG00000160633 E027 3.924158 2.601285e-02 4.278154e-01 5.706424e-01 19 5661488 5661517 30 + 0.586 0.712 0.540
ENSG00000160633 E028 207.718079 1.958856e-04 4.885477e-01 6.260876e-01 19 5661518 5661520 3 + 2.292 2.305 0.043
ENSG00000160633 E029 1326.499636 1.248226e-04 4.867453e-12 1.066656e-10 19 5661521 5661808 288 + 3.053 3.125 0.239
ENSG00000160633 E030 799.152542 1.055606e-04 1.512368e-06 1.208357e-05 19 5664022 5664128 107 + 2.841 2.902 0.202
ENSG00000160633 E031 587.275369 1.050674e-04 9.741684e-04 3.870908e-03 19 5664129 5664159 31 + 2.717 2.764 0.155
ENSG00000160633 E032 695.376068 7.061469e-04 9.834579e-06 6.549943e-05 19 5664397 5664439 43 + 2.769 2.848 0.262
ENSG00000160633 E033 25.592285 4.089443e-02 2.366188e-01 3.702730e-01 19 5664440 5664725 286 + 1.504 1.340 -0.567
ENSG00000160633 E034 137.039040 1.180010e-03 3.238671e-03 1.096890e-02 19 5664726 5666655 1930 + 2.184 2.076 -0.361
ENSG00000160633 E035 46.132295 5.287635e-04 7.276271e-01 8.202724e-01 19 5666656 5667045 390 + 1.642 1.655 0.045
ENSG00000160633 E036 1065.778180 2.268527e-03 5.683493e-05 3.157446e-04 19 5667046 5667164 119 + 2.940 3.038 0.325
ENSG00000160633 E037 17.493653 2.834059e-02 3.145671e-01 4.572847e-01 19 5667165 5667346 182 + 1.160 1.280 0.423
ENSG00000160633 E038 361.558734 3.104355e-03 1.114454e-03 4.352209e-03 19 5667347 5667352 6 + 2.466 2.571 0.350
ENSG00000160633 E039 995.672830 3.674362e-03 9.224915e-07 7.714114e-06 19 5667353 5667450 98 + 2.873 3.023 0.500
ENSG00000160633 E040 30.484948 6.813217e-04 1.449735e-01 2.548019e-01 19 5667451 5667819 369 + 1.420 1.511 0.314
ENSG00000160633 E041 887.482048 2.013540e-03 3.041497e-22 2.488995e-20 19 5667820 5667886 67 + 2.755 2.997 0.805
ENSG00000160633 E042 1068.436886 8.675993e-04 1.303402e-37 3.858212e-35 19 5668162 5668478 317 + 2.844 3.076 0.771