ENSG00000160613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000524507 ENSG00000160613 HEK293_OSMI2_2hA HEK293_TMG_2hB PCSK7 protein_coding protein_coding 28.93432 37.5563 18.67759 2.782402 0.3771052 -1.007359 0.2886283 1.758309 0.000000 1.1733006 0.0000000 -7.4662265 0.008929167 0.05220000 0.00000000 -0.05220000 2.491420e-01 3.656486e-05 FALSE TRUE
ENST00000529458 ENSG00000160613 HEK293_OSMI2_2hA HEK293_TMG_2hB PCSK7 protein_coding processed_transcript 28.93432 37.5563 18.67759 2.782402 0.3771052 -1.007359 1.6804402 1.920665 1.288785 0.5836665 0.2423991 -0.5719344 0.056283333 0.05013333 0.06876667 0.01863333 6.250525e-01 3.656486e-05 FALSE TRUE
ENST00000530269 ENSG00000160613 HEK293_OSMI2_2hA HEK293_TMG_2hB PCSK7 protein_coding protein_coding 28.93432 37.5563 18.67759 2.782402 0.3771052 -1.007359 2.6334339 2.706809 1.784916 0.6463711 0.3938429 -0.5979967 0.094695833 0.07056667 0.09563333 0.02506667 7.047195e-01 3.656486e-05   FALSE
ENST00000676339 ENSG00000160613 HEK293_OSMI2_2hA HEK293_TMG_2hB PCSK7 protein_coding protein_coding 28.93432 37.5563 18.67759 2.782402 0.3771052 -1.007359 15.6097764 22.888750 8.392763 1.8988413 0.1170584 -1.4463332 0.522604167 0.60896667 0.44993333 -0.15903333 3.656486e-05 3.656486e-05 FALSE TRUE
MSTRG.6378.9 ENSG00000160613 HEK293_OSMI2_2hA HEK293_TMG_2hB PCSK7 protein_coding   28.93432 37.5563 18.67759 2.782402 0.3771052 -1.007359 6.1572111 6.213777 5.608147 1.3320016 0.3988763 -0.1476959 0.225591667 0.16240000 0.29983333 0.13743333 1.387391e-02 3.656486e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160613 E001 1.1050505 0.0985525084 8.265878e-01 8.908931e-01 11 117204337 117205067 731 - 0.305 0.266 -0.266
ENSG00000160613 E002 2.1618656 0.0090776845 3.263494e-01 4.697921e-01 11 117205068 117205073 6 - 0.305 0.489 1.037
ENSG00000160613 E003 578.0052031 0.0023170676 9.925073e-14 2.821118e-12 11 117205074 117205946 873 - 2.541 2.745 0.682
ENSG00000160613 E004 105.9961750 0.0005956178 1.614023e-02 4.304219e-02 11 117205947 117206147 201 - 1.885 1.986 0.338
ENSG00000160613 E005 202.7739851 0.0002036914 1.816808e-03 6.653305e-03 11 117206148 117206356 209 - 2.175 2.266 0.307
ENSG00000160613 E006 0.4428904 0.4307212672 6.914525e-01 7.929298e-01 11 117206680 117206680 1 - 0.000 0.158 11.068
ENSG00000160613 E007 128.5148072 0.0003108490 2.842721e-02 6.887116e-02 11 117206681 117206773 93 - 1.989 2.071 0.272
ENSG00000160613 E008 59.9081388 0.0040613276 2.319980e-01 3.648231e-01 11 117206774 117206798 25 - 1.670 1.745 0.255
ENSG00000160613 E009 58.5846104 0.0004820121 4.526135e-01 5.934602e-01 11 117207067 117207160 94 - 1.684 1.725 0.139
ENSG00000160613 E010 1.9038887 0.0086948798 9.009714e-01 9.408478e-01 11 117207654 117207683 30 - 0.402 0.426 0.129
ENSG00000160613 E011 1.5749353 0.0097961923 6.499415e-01 7.610714e-01 11 117207684 117207692 9 - 0.305 0.391 0.521
ENSG00000160613 E012 2.4950723 0.0062367442 5.248378e-01 6.582606e-01 11 117207693 117207735 43 - 0.402 0.518 0.589
ENSG00000160613 E013 0.3686942 0.0301900499 5.147657e-01 6.494936e-01 11 117207775 117207866 92 - 0.179 0.082 -1.284
ENSG00000160613 E014 106.9287454 0.0003259107 3.120698e-01 4.545956e-01 11 117207970 117208064 95 - 1.939 1.980 0.139
ENSG00000160613 E015 6.1969312 0.0087131869 1.217239e-01 2.223938e-01 11 117208065 117208672 608 - 0.936 0.731 -0.798
ENSG00000160613 E016 1.8444412 0.0084305673 6.022727e-01 7.232564e-01 11 117208673 117208736 64 - 0.482 0.391 -0.480
ENSG00000160613 E017 160.4495770 0.0046102707 9.030511e-02 1.756005e-01 11 117208897 117209046 150 - 2.084 2.165 0.269
ENSG00000160613 E018 75.8785132 0.0011669743 1.384360e-02 3.787134e-02 11 117209047 117209053 7 - 1.727 1.851 0.419
ENSG00000160613 E019 5.1000065 0.0371444954 1.787805e-01 2.996180e-01 11 117209054 117209181 128 - 0.549 0.790 1.023
ENSG00000160613 E020 186.7608049 0.0023926086 4.314422e-33 9.091817e-31 11 117209182 117218464 9283 - 2.474 2.068 -1.356
ENSG00000160613 E021 157.1170244 0.0002966390 5.954236e-01 7.175284e-01 11 117218466 117218568 103 - 2.119 2.138 0.064
ENSG00000160613 E022 5.2315325 0.0259594138 2.881640e-04 1.331800e-03 11 117218569 117219056 488 - 1.067 0.544 -2.095
ENSG00000160613 E023 132.6265997 0.0015948588 9.450698e-01 9.695481e-01 11 117219057 117219123 67 - 2.060 2.060 -0.001
ENSG00000160613 E024 112.2285390 0.0003463615 2.979363e-01 4.393207e-01 11 117219124 117219164 41 - 1.957 1.998 0.140
ENSG00000160613 E025 1.7200088 0.0669489833 2.898301e-01 4.305689e-01 11 117219165 117219590 426 - 0.549 0.350 -1.034
ENSG00000160613 E026 170.6634679 0.0002337901 1.885364e-02 4.901357e-02 11 117219591 117219758 168 - 2.113 2.188 0.252
ENSG00000160613 E027 0.2214452 0.0389467746 1.000000e+00   11 117219759 117220138 380 - 0.000 0.082 11.130
ENSG00000160613 E028 11.0705799 0.0016200837 6.297741e-02 1.316729e-01 11 117220319 117223207 2889 - 0.851 1.073 0.828
ENSG00000160613 E029 144.6565130 0.0002762874 5.457578e-01 6.760370e-01 11 117223208 117223308 101 - 2.083 2.105 0.074
ENSG00000160613 E030 6.9749205 0.0229129669 6.092134e-03 1.885351e-02 11 117223309 117224077 769 - 1.086 0.715 -1.418
ENSG00000160613 E031 178.6391467 0.0002620633 4.056066e-03 1.329865e-02 11 117224078 117224216 139 - 2.249 2.168 -0.272
ENSG00000160613 E032 0.1817044 0.0397776135 1.000000e+00   11 117224700 117224700 1 - 0.000 0.082 11.120
ENSG00000160613 E033 126.7189310 0.0002553235 4.164631e-02 9.408598e-02 11 117224701 117224755 55 - 2.092 2.024 -0.228
ENSG00000160613 E034 4.5278633 0.1055807925 5.467791e-01 6.768858e-01 11 117224756 117225930 1175 - 0.747 0.651 -0.398
ENSG00000160613 E035 143.8468426 0.0002493787 3.431539e-03 1.152793e-02 11 117225931 117226021 91 - 2.164 2.072 -0.307
ENSG00000160613 E036 1.3222439 0.0929634176 2.646879e-01 4.026686e-01 11 117226022 117226876 855 - 0.481 0.264 -1.282
ENSG00000160613 E037 173.3918149 0.0012449552 7.563831e-02 1.525253e-01 11 117227157 117227322 166 - 2.219 2.163 -0.188
ENSG00000160613 E038 155.9426123 0.0023601824 7.825754e-01 8.604060e-01 11 117228216 117228350 135 - 2.124 2.139 0.047
ENSG00000160613 E039 182.0502180 0.0002430834 5.350027e-01 6.669583e-01 11 117229377 117229566 190 - 2.213 2.197 -0.054
ENSG00000160613 E040 76.2060172 0.0016015065 8.396499e-01 8.998328e-01 11 117229567 117229569 3 - 1.820 1.832 0.042
ENSG00000160613 E041 257.1055370 0.0030417634 7.495767e-02 1.514672e-01 11 117229570 117229856 287 - 2.393 2.335 -0.192
ENSG00000160613 E042 0.8857808 0.9611403028 6.573215e-01 7.666869e-01 11 117229857 117230240 384 - 0.000 0.289 11.838
ENSG00000160613 E043 119.4003577 0.0064996433 1.544025e-02 4.149149e-02 11 117230349 117230468 120 - 2.106 1.987 -0.399
ENSG00000160613 E044 0.0000000       11 117231127 117231217 91 -      
ENSG00000160613 E045 0.3634088 0.3826854406 6.862207e-01   11 117231787 117232026 240 - 0.000 0.152 11.061
ENSG00000160613 E046 46.3095363 0.0257812312 8.821500e-03 2.583608e-02 11 117232027 117232094 68 - 1.774 1.542 -0.789
ENSG00000160613 E047 4.8533830 0.0039730508 7.583385e-02 1.528334e-01 11 117232350 117232525 176 - 0.881 0.637 -0.987