ENSG00000160584

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000445177 ENSG00000160584 HEK293_OSMI2_2hA HEK293_TMG_2hB SIK3 protein_coding protein_coding 8.976805 9.582372 7.176459 0.5297523 0.2335808 -0.4166064 4.5224817 4.122151 3.8949632 0.5095462 0.3217115 -0.08158393 0.50960000 0.42806667 0.54560000 0.1175333 0.38261453 0.008209025 FALSE TRUE
ENST00000446921 ENSG00000160584 HEK293_OSMI2_2hA HEK293_TMG_2hB SIK3 protein_coding protein_coding 8.976805 9.582372 7.176459 0.5297523 0.2335808 -0.4166064 1.3357513 0.800124 1.3953646 0.1942776 0.1730259 0.79472979 0.15373333 0.08326667 0.19376667 0.1105000 0.01839262 0.008209025 FALSE TRUE
ENST00000488337 ENSG00000160584 HEK293_OSMI2_2hA HEK293_TMG_2hB SIK3 protein_coding processed_transcript 8.976805 9.582372 7.176459 0.5297523 0.2335808 -0.4166064 1.1061377 2.792309 0.2441224 0.4032613 0.1492032 -3.46302056 0.11446250 0.29483333 0.03523333 -0.2596000 0.02267162 0.008209025 FALSE TRUE
ENST00000497049 ENSG00000160584 HEK293_OSMI2_2hA HEK293_TMG_2hB SIK3 protein_coding processed_transcript 8.976805 9.582372 7.176459 0.5297523 0.2335808 -0.4166064 0.4242415 0.821750 0.2413737 0.3104508 0.0408697 -1.72631632 0.04514167 0.08343333 0.03333333 -0.0501000 0.24749688 0.008209025 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160584 E001 0.4417591 0.1332702008 7.982266e-01 8.712089e-01 11 116843402 116843414 13 - 0.138 0.192 0.572
ENSG00000160584 E002 279.9526289 0.0055602335 2.655541e-07 2.484489e-06 11 116843415 116845029 1615 - 2.292 2.508 0.721
ENSG00000160584 E003 60.2400805 0.0077293331 1.459133e-01 2.561135e-01 11 116845030 116845183 154 - 1.703 1.808 0.354
ENSG00000160584 E004 40.7931931 0.0221962325 3.405562e-02 7.986699e-02 11 116845184 116845250 67 - 1.464 1.673 0.714
ENSG00000160584 E005 67.0254299 0.0151039223 2.976182e-01 4.389685e-01 11 116845251 116845411 161 - 1.758 1.849 0.308
ENSG00000160584 E006 100.6439171 0.0060612746 2.463718e-01 3.816980e-01 11 116845412 116845592 181 - 1.948 2.022 0.247
ENSG00000160584 E007 55.5497734 0.0069840057 1.120642e-01 2.085731e-01 11 116845593 116845629 37 - 1.670 1.784 0.388
ENSG00000160584 E008 69.9048647 0.0022283356 8.714380e-04 3.514451e-03 11 116846383 116846457 75 - 1.725 1.902 0.598
ENSG00000160584 E009 94.1781832 0.0027973084 1.014453e-02 2.911982e-02 11 116846458 116846553 96 - 1.883 2.012 0.435
ENSG00000160584 E010 95.2320669 0.0004200215 1.699340e-02 4.491905e-02 11 116847476 116847608 133 - 1.902 2.006 0.350
ENSG00000160584 E011 91.7258209 0.0004161876 6.194826e-05 3.410611e-04 11 116849120 116849283 164 - 1.838 2.008 0.573
ENSG00000160584 E012 0.7468662 0.0733152459 4.408150e-01 5.824818e-01 11 116856914 116857809 896 - 0.328 0.193 -1.007
ENSG00000160584 E013 183.5629816 0.0021576850 1.182239e-02 3.310838e-02 11 116857810 116858519 710 - 2.187 2.287 0.332
ENSG00000160584 E014 46.5939292 0.0005914288 6.422135e-03 1.972047e-02 11 116858520 116858699 180 - 1.734 1.608 -0.428
ENSG00000160584 E015 78.1477593 0.0003763616 1.184909e-01 2.177765e-01 11 116859265 116859604 340 - 1.918 1.870 -0.160
ENSG00000160584 E016 38.2427739 0.0051230601 5.131277e-01 6.479707e-01 11 116861274 116861383 110 - 1.602 1.576 -0.090
ENSG00000160584 E017 0.9524168 0.0129714449 6.640585e-01 7.719533e-01 11 116861384 116861384 1 - 0.243 0.328 0.590
ENSG00000160584 E018 33.5021663 0.0066884601 3.838702e-01 5.280731e-01 11 116861841 116861926 86 - 1.554 1.507 -0.164
ENSG00000160584 E019 37.3661179 0.0005858486 7.557194e-02 1.524298e-01 11 116862202 116862327 126 - 1.626 1.539 -0.295
ENSG00000160584 E020 51.0218218 0.0004572211 8.534228e-04 3.449801e-03 11 116863668 116863818 151 - 1.791 1.643 -0.500
ENSG00000160584 E021 7.3370417 0.0093743491 4.451376e-05 2.538989e-04 11 116863819 116865068 1250 - 1.138 0.643 -1.908
ENSG00000160584 E022 2.1681873 0.0111658001 3.062154e-02 7.318294e-02 11 116867688 116867945 258 - 0.676 0.328 -1.730
ENSG00000160584 E023 50.9443278 0.0036537040 2.020307e-02 5.191046e-02 11 116867946 116868089 144 - 1.772 1.656 -0.391
ENSG00000160584 E024 13.1631101 0.0039885392 5.898536e-01 7.128522e-01 11 116868792 116870140 1349 - 1.172 1.136 -0.129
ENSG00000160584 E025 7.5418185 0.0128060542 3.854185e-01 5.295992e-01 11 116870141 116870330 190 - 0.983 0.890 -0.350
ENSG00000160584 E026 39.9829890 0.0089557810 1.670603e-01 2.843746e-01 11 116870331 116870401 71 - 1.652 1.571 -0.275
ENSG00000160584 E027 47.3388851 0.0100074553 2.306217e-01 3.631984e-01 11 116873481 116873636 156 - 1.716 1.650 -0.224
ENSG00000160584 E028 0.3697384 0.0250495844 2.979952e-01 4.393844e-01 11 116873637 116873672 36 - 0.000 0.195 11.167
ENSG00000160584 E029 45.0233382 0.0006230797 2.922145e-02 7.043378e-02 11 116873903 116874039 137 - 1.713 1.614 -0.336
ENSG00000160584 E030 27.5357765 0.0036622535 9.853673e-03 2.840492e-02 11 116874040 116874056 17 - 1.536 1.368 -0.579
ENSG00000160584 E031 44.3339405 0.0005367239 2.123176e-05 1.308488e-04 11 116875158 116875267 110 - 1.758 1.550 -0.706
ENSG00000160584 E032 37.1995086 0.0005973283 5.737876e-03 1.792230e-02 11 116875374 116875451 78 - 1.655 1.514 -0.484
ENSG00000160584 E033 0.1482932 0.0416073247 6.441479e-01   11 116875452 116875513 62 - 0.000 0.108 10.072
ENSG00000160584 E034 32.8586125 0.0006262876 1.124504e-01 2.091109e-01 11 116875866 116876009 144 - 1.568 1.487 -0.279
ENSG00000160584 E035 47.7212357 0.0005162441 2.467214e-03 8.665461e-03 11 116876253 116876363 111 - 1.758 1.620 -0.467
ENSG00000160584 E036 41.9487060 0.0092547979 6.691160e-02 1.382401e-01 11 116876924 116877042 119 - 1.690 1.580 -0.373
ENSG00000160584 E037 4.1181675 0.0041986433 4.138922e-02 9.360452e-02 11 116893845 116893967 123 - 0.459 0.785 1.442
ENSG00000160584 E038 41.0337242 0.0058120142 2.132016e-02 5.426264e-02 11 116896253 116896376 124 - 1.690 1.557 -0.453
ENSG00000160584 E039 39.8249081 0.0232520570 2.695159e-01 4.080146e-01 11 116897193 116897317 125 - 1.641 1.564 -0.261
ENSG00000160584 E040 0.0000000       11 116904746 116905003 258 -      
ENSG00000160584 E041 58.3002279 0.0172563803 1.170556e-01 2.157455e-01 11 116927219 116927380 162 - 1.816 1.716 -0.341
ENSG00000160584 E042 1.2899917 0.0127084310 2.557460e-01 3.926696e-01 11 116950133 116950256 124 - 0.459 0.267 -1.145
ENSG00000160584 E043 36.2293589 0.0138577496 1.588501e-02 4.247938e-02 11 116954044 116954107 64 - 1.656 1.475 -0.619
ENSG00000160584 E044 40.4964610 0.0247615321 2.721544e-03 9.437133e-03 11 116956948 116957064 117 - 1.740 1.487 -0.864
ENSG00000160584 E045 23.2854636 0.0165346577 3.397072e-05 1.993572e-04 11 117098143 117098437 295 - 1.559 1.191 -1.280