ENSG00000160551

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261716 ENSG00000160551 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK1 protein_coding protein_coding 4.983098 1.391172 8.348935 0.1577695 0.7195233 2.576685 3.7104145 0.33286411 7.0799397 0.04319495 0.3347718 4.3700646 0.57732500 0.2462333 0.85910000 0.612866667 0.0007768416 0.0007768416 FALSE TRUE
ENST00000536202 ENSG00000160551 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK1 protein_coding protein_coding 4.983098 1.391172 8.348935 0.1577695 0.7195233 2.576685 0.9594052 0.94359624 0.7131677 0.07885358 0.4010507 -0.3990483 0.34799583 0.6830333 0.08160000 -0.601433333 0.0251822118 0.0007768416 FALSE TRUE
ENST00000578653 ENSG00000160551 HEK293_OSMI2_2hA HEK293_TMG_2hB TAOK1 protein_coding retained_intron 4.983098 1.391172 8.348935 0.1577695 0.7195233 2.576685 0.2934229 0.09984001 0.5376589 0.09984001 0.4217051 2.3178740 0.06760417 0.0602000 0.05703333 -0.003166667 0.9685376662 0.0007768416 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160551 E001 6.5933871 0.0098258316 8.457261e-01 9.040603e-01 17 29390363 29390463 101 + 0.745 0.781 0.145
ENSG00000160551 E002 8.5122321 0.0022756793 5.931130e-01 7.155588e-01 17 29390464 29390588 125 + 0.857 0.780 -0.303
ENSG00000160551 E003 3.8848307 0.0045652821 1.029032e-01 1.948940e-01 17 29390589 29390661 73 + 0.619 0.264 -1.918
ENSG00000160551 E004 5.7249830 0.0029388799 2.935305e-01 4.346076e-01 17 29390662 29390924 263 + 0.735 0.545 -0.818
ENSG00000160551 E005 1.9938578 0.0962188079 8.175641e-01 8.846424e-01 17 29390925 29390930 6 + 0.379 0.427 0.269
ENSG00000160551 E006 2.7450922 0.0074897988 7.781550e-01 8.572488e-01 17 29390931 29390955 25 + 0.481 0.427 -0.274
ENSG00000160551 E007 6.5888973 0.0211121947 6.443359e-02 1.340959e-01 17 29390956 29391024 69 + 0.800 0.427 -1.667
ENSG00000160551 E008 28.9658828 0.0008917973 6.162059e-05 3.394050e-04 17 29451455 29451680 226 + 1.385 0.931 -1.628
ENSG00000160551 E009 0.1472490 0.0441567750 8.501383e-01   17 29451681 29451707 27 + 0.052 0.001 -6.269
ENSG00000160551 E010 18.3709316 0.0009811358 1.186157e-04 6.075152e-04 17 29467145 29467216 72 + 1.206 0.638 -2.169
ENSG00000160551 E011 23.1401869 0.0008332728 6.439850e-05 3.529509e-04 17 29475670 29475771 102 + 1.298 0.780 -1.909
ENSG00000160551 E012 16.0913310 0.0010595091 2.577789e-03 8.997779e-03 17 29477661 29477706 46 + 1.147 0.715 -1.639
ENSG00000160551 E013 20.4607832 0.0008581085 1.484594e-03 5.586716e-03 17 29478251 29478347 97 + 1.242 0.836 -1.489
ENSG00000160551 E014 0.0000000       17 29480071 29480367 297 +      
ENSG00000160551 E015 22.7802540 0.0009241909 4.811106e-07 4.268685e-06 17 29480368 29480481 114 + 1.301 0.545 -2.918
ENSG00000160551 E016 26.8468897 0.0015271891 9.365939e-07 7.817894e-06 17 29482197 29482288 92 + 1.364 0.715 -2.404
ENSG00000160551 E017 31.1619774 0.0007931794 7.123413e-07 6.107331e-06 17 29489664 29489757 94 + 1.424 0.836 -2.125
ENSG00000160551 E018 28.7951565 0.0021774472 5.901079e-06 4.133177e-05 17 29491784 29491865 82 + 1.390 0.836 -2.007
ENSG00000160551 E019 40.6694651 0.0006011667 2.928948e-06 2.196589e-05 17 29495560 29495727 168 + 1.527 1.075 -1.585
ENSG00000160551 E020 41.3566634 0.0005469686 4.761347e-05 2.696872e-04 17 29498318 29498521 204 + 1.529 1.158 -1.291
ENSG00000160551 E021 45.6979143 0.0004709397 6.175748e-05 3.400503e-04 17 29502589 29502723 135 + 1.569 1.228 -1.181
ENSG00000160551 E022 61.7054025 0.0074495166 2.772516e-04 1.287023e-03 17 29507896 29508132 237 + 1.694 1.389 -1.044
ENSG00000160551 E023 35.8531358 0.0087275954 1.139202e-02 3.210056e-02 17 29510864 29510992 129 + 1.462 1.206 -0.891
ENSG00000160551 E024 0.2998086 0.0288792740 1.754470e-01   17 29510993 29514997 4005 + 0.052 0.264 2.723
ENSG00000160551 E025 45.6763583 0.0018290540 7.804607e-05 4.187842e-04 17 29517453 29517656 204 + 1.572 1.228 -1.192
ENSG00000160551 E026 16.0597191 0.0012917767 1.330203e-04 6.722229e-04 17 29522280 29522287 8 + 1.155 0.545 -2.403
ENSG00000160551 E027 49.2265047 0.0004895161 1.618423e-09 2.308254e-08 17 29522288 29522519 232 + 1.615 1.043 -2.002
ENSG00000160551 E028 38.8426826 0.0005083091 2.118697e-03 7.592131e-03 17 29530407 29530619 213 + 1.496 1.228 -0.933
ENSG00000160551 E029 0.8930831 0.1800273989 7.351622e-02 1.491467e-01 17 29530620 29530738 119 + 0.140 0.537 2.685
ENSG00000160551 E030 35.7352124 0.0005537066 4.487936e-04 1.962256e-03 17 29534118 29534300 183 + 1.466 1.132 -1.168
ENSG00000160551 E031 1059.4688216 0.0001825345 3.341956e-91 7.721019e-88 17 29542561 29551903 9343 + 2.854 3.027 0.575