ENSG00000160447

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291906 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding protein_coding 21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 4.425847 6.362129 4.3449755 0.9647080 0.5715645 -0.5491108 0.19719583 0.19013333 0.26706667 0.07693333 0.340077024 0.008123293 FALSE TRUE
ENST00000485301 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding processed_transcript 21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 5.237736 7.997203 5.8413734 1.0738104 0.7180496 -0.4525232 0.25052500 0.24060000 0.35756667 0.11696667 0.163801392 0.008123293 FALSE FALSE
MSTRG.33465.1 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding   21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 1.531920 1.308852 1.0217639 0.2234762 0.0665912 -0.3541702 0.07707917 0.03903333 0.06270000 0.02366667 0.119261091 0.008123293 FALSE TRUE
MSTRG.33465.4 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding   21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 3.112378 6.579249 1.0006101 1.5987592 0.5472023 -2.7048876 0.12879167 0.20036667 0.06366667 -0.13670000 0.459084108 0.008123293 FALSE TRUE
MSTRG.33465.5 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding   21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 3.502448 7.677169 0.2796013 1.3787816 0.2796013 -4.7303122 0.14906250 0.23283333 0.01796667 -0.21486667 0.028319499 0.008123293 FALSE TRUE
MSTRG.33465.6 ENSG00000160447 HEK293_OSMI2_2hA HEK293_TMG_2hB PKN3 protein_coding   21.64952 33.20478 16.27599 2.299867 0.5993298 -1.028194 3.770847 2.967107 3.7876648 0.7308996 0.5284598 0.3512016 0.19428750 0.08820000 0.23100000 0.14280000 0.008123293 0.008123293 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160447 E001 0.000000       9 128702095 128702431 337 +      
ENSG00000160447 E002 0.584854 0.0395356829 3.504662e-01 4.946343e-01 9 128702432 128702502 71 + 0.000 0.208 10.344
ENSG00000160447 E003 0.584854 0.0395356829 3.504662e-01 4.946343e-01 9 128702503 128702510 8 + 0.000 0.208 10.338
ENSG00000160447 E004 19.753354 0.0010003398 1.033246e-01 1.955400e-01 9 128702511 128702600 90 + 1.348 1.212 -0.479
ENSG00000160447 E005 22.584744 0.0023272857 3.023264e-02 7.242826e-02 9 128702601 128702647 47 + 1.431 1.258 -0.601
ENSG00000160447 E006 38.897931 0.0006288345 1.807865e-03 6.623883e-03 9 128702648 128702793 146 + 1.665 1.476 -0.643
ENSG00000160447 E007 58.153050 0.0106962975 1.785977e-01 2.993939e-01 9 128702794 128702939 146 + 1.768 1.677 -0.310
ENSG00000160447 E008 37.760054 0.0083767713 4.980885e-09 6.503196e-08 9 128703071 128703469 399 + 1.787 1.371 -1.423
ENSG00000160447 E009 29.810806 0.0006664070 2.932330e-03 1.006452e-02 9 128705101 128705302 202 + 1.560 1.358 -0.696
ENSG00000160447 E010 119.379169 0.0090087638 8.354697e-01 8.971055e-01 9 128705303 128705543 241 + 2.018 2.009 -0.030
ENSG00000160447 E011 36.188502 0.0006482674 2.563442e-01 3.932980e-01 9 128705734 128705748 15 + 1.554 1.479 -0.256
ENSG00000160447 E012 91.491692 0.0087503865 8.411386e-01 9.008969e-01 9 128705749 128705879 131 + 1.886 1.901 0.051
ENSG00000160447 E013 107.492374 0.0003674145 6.307192e-01 7.458575e-01 9 128706713 128706824 112 + 1.980 1.960 -0.069
ENSG00000160447 E014 135.132277 0.0002457901 9.641902e-01 9.814309e-01 9 128706896 128707023 128 + 2.066 2.062 -0.012
ENSG00000160447 E015 139.423594 0.0039056479 2.781662e-01 4.177984e-01 9 128707222 128707405 184 + 2.115 2.067 -0.162
ENSG00000160447 E016 103.296304 0.0023434026 2.847374e-01 4.249829e-01 9 128713052 128713116 65 + 1.985 1.937 -0.163
ENSG00000160447 E017 107.388168 0.0022244625 5.674438e-01 6.942415e-01 9 128713117 128713198 82 + 1.944 1.969 0.086
ENSG00000160447 E018 148.720456 0.0002409798 5.273955e-01 6.604636e-01 9 128713278 128713387 110 + 2.122 2.100 -0.075
ENSG00000160447 E019 191.743632 0.0002152790 2.708963e-02 6.617513e-02 9 128713499 128713642 144 + 2.262 2.198 -0.216
ENSG00000160447 E020 104.991035 0.0010403939 8.945151e-01 9.366146e-01 9 128714046 128714121 76 + 1.954 1.957 0.012
ENSG00000160447 E021 146.708312 0.0013215672 6.700191e-01 7.766122e-01 9 128714197 128714365 169 + 2.085 2.101 0.053
ENSG00000160447 E022 70.899961 0.0004259913 2.707923e-01 4.094466e-01 9 128714562 128714605 44 + 1.745 1.797 0.175
ENSG00000160447 E023 84.529719 0.0003418345 9.830168e-01 9.934566e-01 9 128714606 128714664 59 + 1.865 1.862 -0.009
ENSG00000160447 E024 132.112878 0.0007819636 5.223658e-01 6.561941e-01 9 128714798 128714865 68 + 2.072 2.047 -0.082
ENSG00000160447 E025 139.016384 0.0003060067 1.373349e-01 2.443595e-01 9 128715172 128715235 64 + 2.115 2.064 -0.173
ENSG00000160447 E026 177.660716 0.0002074525 7.284890e-01 8.209606e-01 9 128715369 128715460 92 + 2.177 2.185 0.028
ENSG00000160447 E027 302.911756 0.0001675551 5.983576e-01 7.199696e-01 9 128716747 128716923 177 + 2.422 2.409 -0.046
ENSG00000160447 E028 200.671121 0.0002410717 8.971625e-01 9.383299e-01 9 128718325 128718387 63 + 2.232 2.233 0.006
ENSG00000160447 E029 211.868584 0.0051523957 6.162267e-01 7.343253e-01 9 128718549 128718625 77 + 2.276 2.257 -0.061
ENSG00000160447 E030 272.158475 0.0044366653 5.887701e-01 7.119296e-01 9 128719686 128719828 143 + 2.383 2.366 -0.059
ENSG00000160447 E031 211.576206 0.0026925902 1.633446e-01 2.795330e-01 9 128719910 128720017 108 + 2.221 2.274 0.177
ENSG00000160447 E032 172.910574 0.0010828876 1.214972e-03 4.691372e-03 9 128720203 128720283 81 + 2.087 2.198 0.373
ENSG00000160447 E033 262.377010 0.0003198056 1.423725e-05 9.125773e-05 9 128720394 128720555 162 + 2.263 2.376 0.377
ENSG00000160447 E034 300.514449 0.0005692175 3.326686e-06 2.466656e-05 9 128720556 128720916 361 + 2.319 2.438 0.397