ENSG00000160360

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291775 ENSG00000160360 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM1 protein_coding protein_coding 19.65232 35.57895 13.53064 2.538674 0.2477732 -1.394133 2.484183 5.005247 1.1287345 0.4427677 0.04242164 -2.1388893 0.1144625 0.14110000 0.0836000 -0.057500000 1.497936e-02 1.792841e-57 FALSE TRUE
ENST00000392944 ENSG00000160360 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM1 protein_coding protein_coding 19.65232 35.57895 13.53064 2.538674 0.2477732 -1.394133 1.672201 2.062976 0.7268999 0.2000365 0.06260679 -1.4921632 0.0868625 0.05896667 0.0537000 -0.005266667 9.013788e-01 1.792841e-57 FALSE TRUE
ENST00000440944 ENSG00000160360 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM1 protein_coding protein_coding 19.65232 35.57895 13.53064 2.538674 0.2477732 -1.394133 6.969400 8.530709 9.8866140 2.1376539 0.16509430 0.2125791 0.3461958 0.23700000 0.7315667 0.494566667 8.822853e-07 1.792841e-57 FALSE TRUE
MSTRG.33625.5 ENSG00000160360 HEK293_OSMI2_2hA HEK293_TMG_2hB GPSM1 protein_coding   19.65232 35.57895 13.53064 2.538674 0.2477732 -1.394133 6.564147 17.029542 0.0000000 1.7672343 0.00000000 -10.7346708 0.3408583 0.47733333 0.0000000 -0.477333333 1.792841e-57 1.792841e-57 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160360 E001 2.3780148 0.0326406692 5.532280e-01 6.824159e-01 9 136327476 136327487 12 + 0.545 0.463 -0.399
ENSG00000160360 E002 4.6966733 0.0265467550 2.061580e-03 7.416215e-03 9 136327488 136327538 51 + 0.979 0.549 -1.749
ENSG00000160360 E003 55.9145256 0.0111930848 2.622611e-10 4.302813e-09 9 136327539 136327763 225 + 1.946 1.553 -1.332
ENSG00000160360 E004 0.2214452 0.0366852686 1.000000e+00   9 136328170 136328208 39 + 0.000 0.083 10.014
ENSG00000160360 E005 0.3299976 0.0279937877 6.071494e-01   9 136331983 136332170 188 + 0.000 0.153 11.008
ENSG00000160360 E006 183.2441217 0.0002164292 2.147521e-08 2.489088e-07 9 136334447 136334668 222 + 2.287 2.166 -0.407
ENSG00000160360 E007 194.3922956 0.0002067746 1.004303e-02 2.886871e-02 9 136335966 136336101 136 + 2.252 2.216 -0.122
ENSG00000160360 E008 225.1863242 0.0023360084 1.444135e-02 3.922635e-02 9 136336921 136337072 152 + 2.321 2.279 -0.140
ENSG00000160360 E009 199.1658250 0.0017628903 2.120526e-02 5.402393e-02 9 136337441 136337564 124 + 2.264 2.227 -0.126
ENSG00000160360 E010 181.3679353 0.0003317897 2.416112e-01 3.760783e-01 9 136337846 136337961 116 + 2.194 2.195 0.003
ENSG00000160360 E011 188.2461567 0.0028492941 6.409368e-01 7.540571e-01 9 136338555 136338710 156 + 2.169 2.227 0.195
ENSG00000160360 E012 138.0171587 0.0027992168 3.570079e-01 5.014240e-01 9 136339707 136339815 109 + 2.019 2.097 0.263
ENSG00000160360 E013 167.8601342 0.0005706610 3.913147e-01 5.352265e-01 9 136340870 136340993 124 + 2.113 2.177 0.216
ENSG00000160360 E014 7.5511733 0.0022449599 4.408696e-01 5.825139e-01 9 136340994 136341836 843 + 0.780 0.912 0.513
ENSG00000160360 E015 135.2224383 0.0011079699 1.822029e-01 3.039555e-01 9 136348697 136348767 71 + 2.083 2.070 -0.042
ENSG00000160360 E016 84.1430282 0.0004352328 9.541855e-02 1.835148e-01 9 136349587 136349592 6 + 1.894 1.858 -0.121
ENSG00000160360 E017 198.8686568 0.0002022297 9.578418e-02 1.840648e-01 9 136349593 136349763 171 + 2.244 2.233 -0.036
ENSG00000160360 E018 14.1815922 0.0018266812 1.601358e-03 5.965556e-03 9 136353057 136353155 99 + 1.303 1.046 -0.915
ENSG00000160360 E019 22.6501967 0.0008903897 7.155409e-03 2.162616e-02 9 136354808 136355022 215 + 1.433 1.262 -0.595
ENSG00000160360 E020 16.7385092 0.0011097142 2.773860e-01 4.169466e-01 9 136355530 136355689 160 + 1.232 1.168 -0.229
ENSG00000160360 E021 193.2005070 0.0003077558 3.038812e-01 4.458612e-01 9 136355690 136355846 157 + 2.217 2.223 0.021
ENSG00000160360 E022 246.0427499 0.0002674096 6.636150e-01 7.716189e-01 9 136356342 136356550 209 + 2.307 2.332 0.083
ENSG00000160360 E023 96.2730203 0.0003454233 7.967649e-01 8.703043e-01 9 136358014 136358021 8 + 1.886 1.932 0.155
ENSG00000160360 E024 1144.2330781 0.0041367689 2.611430e-08 2.975984e-07 9 136358022 136359605 1584 + 2.858 3.041 0.608