ENSG00000160323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371910 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding protein_coding 3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.8879072 0.7378087 0.35346484 0.41477081 0.35346484 -1.0408534 0.22073333 0.16970000 0.09280000 -0.076900000 6.309505e-01 5.241484e-07 FALSE TRUE
ENST00000371929 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding protein_coding 3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.5046474 0.5617612 0.51559280 0.18522071 0.07922993 -0.1214672 0.13785000 0.14763333 0.18616667 0.038533333 8.707506e-01 5.241484e-07 FALSE TRUE
MSTRG.33597.19 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.3273035 0.7600063 0.00000000 0.12177989 0.00000000 -6.2667983 0.08137083 0.21653333 0.00000000 -0.216533333 5.241484e-07 5.241484e-07 TRUE TRUE
MSTRG.33597.2 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.5223758 0.3960290 0.67965445 0.02152248 0.14010967 0.7642910 0.15433333 0.10860000 0.24433333 0.135733333 2.193177e-01 5.241484e-07 FALSE TRUE
MSTRG.33597.21 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.2095990 0.4709809 0.09819814 0.08495209 0.09819814 -2.1523038 0.05068750 0.12290000 0.03856667 -0.084333333 2.184432e-01 5.241484e-07 FALSE TRUE
MSTRG.33597.3 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.2293515 0.1003097 0.30398658 0.10030971 0.07985045 1.5091432 0.06612500 0.02076667 0.10870000 0.087933333 1.913735e-01 5.241484e-07 TRUE TRUE
MSTRG.33597.4 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.2259302 0.1657351 0.18070675 0.10110755 0.06580957 0.1179534 0.06006667 0.04883333 0.05806667 0.009233333 8.295966e-01 5.241484e-07 FALSE TRUE
MSTRG.33597.7 ENSG00000160323 HEK293_OSMI2_2hA HEK293_TMG_2hB ADAMTS13 protein_coding   3.647197 3.793733 2.967258 0.5649644 0.4206141 -0.3534315 0.3037333 0.1424949 0.40299969 0.14249491 0.02068434 1.4373796 0.09561250 0.04946667 0.14003333 0.090566667 2.365950e-01 5.241484e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160323 E001 0.000000       9 133414358 133414644 287 +      
ENSG00000160323 E002 17.325954 0.0048125052 1.109291e-04 5.720910e-04 9 133418140 133418501 362 + 1.420 1.094 -1.151
ENSG00000160323 E003 9.576112 0.0085754154 2.378784e-02 5.937778e-02 9 133418502 133418547 46 + 1.147 0.904 -0.894
ENSG00000160323 E004 8.975351 0.0019859358 2.158282e-03 7.714862e-03 9 133418548 133418631 84 + 1.158 0.836 -1.195
ENSG00000160323 E005 7.859692 0.0040437055 7.001720e-04 2.899642e-03 9 133418632 133418662 31 + 1.136 0.754 -1.438
ENSG00000160323 E006 10.553957 0.0075201798 1.594624e-01 2.744064e-01 9 133421769 133421844 76 + 1.136 0.990 -0.528
ENSG00000160323 E007 13.365903 0.0179995022 8.818202e-01 9.282764e-01 9 133421845 133421921 77 + 1.158 1.142 -0.055
ENSG00000160323 E008 10.166710 0.0017707573 8.243863e-01 8.893683e-01 9 133421922 133421956 35 + 1.047 1.028 -0.069
ENSG00000160323 E009 9.291524 0.0018079777 7.709764e-01 8.521587e-01 9 133421957 133421978 22 + 1.017 0.990 -0.100
ENSG00000160323 E010 12.953727 0.0376969430 9.714109e-01 9.861337e-01 9 133422000 133422323 324 + 1.124 1.136 0.045
ENSG00000160323 E011 3.064589 0.0062855036 9.995368e-01 1.000000e+00 9 133422324 133422324 1 + 0.591 0.594 0.016
ENSG00000160323 E012 5.142220 0.0044116596 2.545464e-01 3.912525e-01 9 133422325 133422366 42 + 0.855 0.707 -0.586
ENSG00000160323 E013 4.513344 0.0335285120 2.870327e-01 4.274926e-01 9 133422367 133422382 16 + 0.808 0.656 -0.620
ENSG00000160323 E014 12.138993 0.0027515073 2.588312e-04 1.211933e-03 9 133422383 133422523 141 + 1.281 0.935 -1.250
ENSG00000160323 E015 7.261130 0.0024239260 5.284669e-03 1.670668e-02 9 133422524 133422548 25 + 1.074 0.754 -1.214
ENSG00000160323 E016 15.334050 0.0011979268 1.277413e-06 1.037154e-05 9 133423101 133423167 67 + 1.402 0.990 -1.466
ENSG00000160323 E017 19.074388 0.0010206430 7.735757e-05 4.155253e-04 9 133424321 133424478 158 + 1.444 1.142 -1.056
ENSG00000160323 E018 15.838935 0.0013918484 4.777934e-02 1.052298e-01 9 133425529 133425612 84 + 1.297 1.133 -0.580
ENSG00000160323 E019 14.540613 0.0327896597 4.018386e-01 5.455342e-01 9 133425938 133426062 125 + 1.239 1.135 -0.368
ENSG00000160323 E020 11.084423 0.0019461275 2.583482e-01 3.955908e-01 9 133426199 133426345 147 + 1.124 1.016 -0.393
ENSG00000160323 E021 4.176101 0.0047374492 1.230697e-02 3.427155e-02 9 133428634 133428771 138 + 0.876 0.524 -1.476
ENSG00000160323 E022 7.680055 0.0021984386 8.711165e-01 9.211394e-01 9 133429700 133429850 151 + 0.935 0.920 -0.055
ENSG00000160323 E023 5.811651 0.0525093957 8.330263e-01 8.953806e-01 9 133429851 133429888 38 + 0.783 0.839 0.219
ENSG00000160323 E024 4.740012 0.0067999560 8.726927e-01 9.221266e-01 9 133429889 133429924 36 + 0.728 0.755 0.109
ENSG00000160323 E025 3.369595 0.0060801533 6.951121e-01 7.957874e-01 9 133429925 133429938 14 + 0.591 0.654 0.278
ENSG00000160323 E026 2.592553 0.0068195801 7.302373e-01 8.222705e-01 9 133429939 133429943 5 + 0.501 0.561 0.279
ENSG00000160323 E027 8.011121 0.0249636062 4.453265e-01 5.868760e-01 9 133429944 133430031 88 + 0.876 0.979 0.387
ENSG00000160323 E028 10.397569 0.0281976740 5.758726e-01 7.013876e-01 9 133430032 133430101 70 + 1.003 1.074 0.261
ENSG00000160323 E029 1.507083 0.2914960230 8.147974e-01 8.826475e-01 9 133430102 133430181 80 + 0.448 0.380 -0.365
ENSG00000160323 E030 16.208590 0.0139263278 1.522704e-01 2.647768e-01 9 133432588 133432692 105 + 1.136 1.281 0.516
ENSG00000160323 E031 17.195661 0.0119198129 2.164315e-02 5.493416e-02 9 133433378 133433529 152 + 1.100 1.327 0.804
ENSG00000160323 E032 5.815377 0.0028853439 5.955675e-01 7.176289e-01 9 133433641 133433653 13 + 0.783 0.854 0.278
ENSG00000160323 E033 6.329357 0.0029140995 7.682335e-01 8.502650e-01 9 133433654 133433704 51 + 0.832 0.871 0.153
ENSG00000160323 E034 14.990602 0.0012235181 1.164525e-01 2.148940e-01 9 133436829 133436955 127 + 1.264 1.133 -0.465
ENSG00000160323 E035 16.720803 0.0012336692 4.665132e-02 1.032073e-01 9 133437749 133437897 149 + 1.320 1.160 -0.564
ENSG00000160323 E036 9.598910 0.0018219149 2.731305e-01 4.121170e-01 9 133438246 133438366 121 + 1.074 0.964 -0.406
ENSG00000160323 E037 15.773404 0.0011637677 4.438224e-01 5.854028e-01 9 133439366 133439446 81 + 1.247 1.186 -0.215
ENSG00000160323 E038 27.828596 0.0006883708 3.970559e-01 5.408357e-01 9 133440344 133440525 182 + 1.408 1.468 0.206
ENSG00000160323 E039 11.148836 0.0016404978 4.718233e-01 6.109114e-01 9 133442399 133442518 120 + 1.018 1.094 0.279
ENSG00000160323 E040 2.330309 0.0065239188 6.811436e-01 7.849138e-01 9 133442519 133442534 16 + 0.548 0.484 -0.307
ENSG00000160323 E041 7.639471 0.0022787590 5.569135e-01 6.854618e-01 9 133442614 133442743 130 + 0.952 0.889 -0.242
ENSG00000160323 E042 7.925557 0.0047697691 2.368761e-01 3.705634e-01 9 133443376 133443561 186 + 0.832 0.978 0.555
ENSG00000160323 E043 28.568959 0.0007437067 5.900106e-01 7.129707e-01 9 133444863 133445052 190 + 1.438 1.477 0.132
ENSG00000160323 E044 22.871612 0.0009283956 6.045127e-01 7.250379e-01 9 133445699 133445819 121 + 1.383 1.350 -0.116
ENSG00000160323 E045 23.545806 0.0264464883 4.815412e-01 6.197749e-01 9 133448599 133448728 130 + 1.420 1.352 -0.238
ENSG00000160323 E046 31.030463 0.0011851160 9.240236e-02 1.788669e-01 9 133449783 133449965 183 + 1.421 1.533 0.385
ENSG00000160323 E047 37.124331 0.0008179126 6.074378e-02 1.278778e-01 9 133454415 133454619 205 + 1.497 1.611 0.388
ENSG00000160323 E048 26.853451 0.0007939175 4.950609e-01 6.319337e-01 9 133455285 133455435 151 + 1.396 1.446 0.173
ENSG00000160323 E049 17.681739 0.0023010630 1.008501e-01 1.917593e-01 9 133455436 133455501 66 + 1.158 1.302 0.509
ENSG00000160323 E050 20.569475 0.0193576659 8.009846e-03 2.380225e-02 9 133455502 133455603 102 + 1.124 1.406 0.993
ENSG00000160323 E051 7.292366 0.0022943842 3.572878e-02 8.306083e-02 9 133455604 133455647 44 + 0.728 0.990 1.016
ENSG00000160323 E052 14.603424 0.0079203273 9.678182e-02 1.855565e-01 9 133455648 133455799 152 + 1.074 1.241 0.595
ENSG00000160323 E053 33.107007 0.0007731487 4.331881e-02 9.714619e-02 9 133456069 133456215 147 + 1.432 1.562 0.443
ENSG00000160323 E054 33.083189 0.0006974418 8.835581e-02 1.726106e-01 9 133456543 133456719 177 + 1.449 1.558 0.372
ENSG00000160323 E055 25.384291 0.0018451303 2.993136e-03 1.024408e-02 9 133457910 133458094 185 + 1.264 1.485 0.767
ENSG00000160323 E056 51.855471 0.0079396903 5.467604e-05 3.050888e-04 9 133458974 133459450 477 + 1.531 1.802 0.922