ENSG00000160285

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457828 ENSG00000160285 HEK293_OSMI2_2hA HEK293_TMG_2hB LSS protein_coding protein_coding 46.88716 70.3588 26.94257 4.409765 0.7104011 -1.384513 25.681202 48.368816 10.660408 2.9522890 0.2050017 -2.1807601 0.51157500 0.68770000 0.3966333 -0.29106667 1.287322e-19 1.287322e-19 FALSE TRUE
ENST00000522411 ENSG00000160285 HEK293_OSMI2_2hA HEK293_TMG_2hB LSS protein_coding protein_coding 46.88716 70.3588 26.94257 4.409765 0.7104011 -1.384513 4.085108 3.206520 5.573973 1.4032548 0.0808287 0.7957912 0.11020833 0.04346667 0.2071000 0.16363333 1.316943e-02 1.287322e-19 FALSE TRUE
MSTRG.21506.6 ENSG00000160285 HEK293_OSMI2_2hA HEK293_TMG_2hB LSS protein_coding   46.88716 70.3588 26.94257 4.409765 0.7104011 -1.384513 2.862337 2.427741 1.895891 0.3868788 0.1140453 -0.3550789 0.06509583 0.03456667 0.0703000 0.03573333 3.971484e-03 1.287322e-19 TRUE TRUE
MSTRG.21506.8 ENSG00000160285 HEK293_OSMI2_2hA HEK293_TMG_2hB LSS protein_coding   46.88716 70.3588 26.94257 4.409765 0.7104011 -1.384513 4.143197 2.235733 3.358486 0.5828942 0.3325530 0.5849140 0.10207500 0.03120000 0.1252000 0.09400000 1.587755e-05 1.287322e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160285 E001 0.4439371 0.0215542607 7.442388e-03 2.236754e-02 21 46188108 46188140 33 - 0.423 0.000 -12.115
ENSG00000160285 E002 1.1394067 0.0111204287 2.987764e-01 4.402484e-01 21 46188141 46188445 305 - 0.423 0.248 -1.094
ENSG00000160285 E003 1.8434090 0.0079089621 8.439120e-01 9.028325e-01 21 46188446 46188473 28 - 0.423 0.405 -0.095
ENSG00000160285 E004 37.8549940 0.0051991751 4.540436e-01 5.947282e-01 21 46188474 46188821 348 - 1.446 1.533 0.301
ENSG00000160285 E005 7.5974655 0.0021619388 8.234415e-04 3.343231e-03 21 46188822 46189123 302 - 1.117 0.751 -1.383
ENSG00000160285 E006 2.6153572 0.0059592470 1.623954e-03 6.037743e-03 21 46189124 46189124 1 - 0.812 0.334 -2.245
ENSG00000160285 E007 1727.3330839 0.0063039825 3.887388e-10 6.212704e-09 21 46189125 46190207 1083 - 2.945 3.206 0.866
ENSG00000160285 E008 1015.6657719 0.0013586121 1.397474e-13 3.889337e-12 21 46190208 46190782 575 - 2.769 2.965 0.650
ENSG00000160285 E009 557.5648591 0.0001125873 9.346414e-09 1.159106e-07 21 46190783 46191065 283 - 2.552 2.692 0.464
ENSG00000160285 E010 167.1871478 0.0002350423 3.861394e-01 5.303321e-01 21 46191066 46191075 10 - 2.099 2.158 0.198
ENSG00000160285 E011 529.7636208 0.0001754341 6.900922e-02 1.417299e-01 21 46191076 46191235 160 - 2.591 2.657 0.219
ENSG00000160285 E012 403.8629178 0.0004629892 1.872821e-01 3.103165e-01 21 46191881 46191959 79 - 2.477 2.539 0.207
ENSG00000160285 E013 153.6058212 0.0053168010 5.658671e-12 1.226145e-10 21 46191960 46192680 721 - 2.312 2.029 -0.948
ENSG00000160285 E014 52.4749778 0.0041652305 6.820132e-19 3.833987e-17 21 46192681 46193021 341 - 1.965 1.486 -1.623
ENSG00000160285 E015 21.6448413 0.0022984003 1.710085e-11 3.426084e-10 21 46193022 46193148 127 - 1.602 1.119 -1.683
ENSG00000160285 E016 17.0814410 0.0405527371 1.473347e-06 1.180366e-05 21 46193149 46193265 117 - 1.553 0.968 -2.066
ENSG00000160285 E017 0.2998086 0.0291550432 4.150607e-01   21 46193266 46193291 26 - 0.190 0.076 -1.512
ENSG00000160285 E018 4.1584867 0.0070706035 1.109654e-10 1.943248e-09 21 46193292 46193412 121 - 1.135 0.248 -4.033
ENSG00000160285 E019 13.8573789 0.0100971437 1.384161e-08 1.662072e-07 21 46193413 46193507 95 - 1.446 0.910 -1.916
ENSG00000160285 E020 19.0525225 0.0104652445 1.496954e-13 4.149136e-12 21 46193508 46193626 119 - 1.625 0.993 -2.222
ENSG00000160285 E021 31.2951149 0.0017116844 5.145039e-21 3.717438e-19 21 46193627 46193747 121 - 1.796 1.221 -1.976
ENSG00000160285 E022 11.2458763 0.0015601548 2.486040e-14 7.710753e-13 21 46193748 46193773 26 - 1.446 0.735 -2.601
ENSG00000160285 E023 37.1444796 0.0139688567 2.696916e-08 3.064371e-07 21 46193774 46194015 242 - 1.781 1.364 -1.424
ENSG00000160285 E024 85.1359163 0.0002934607 8.505031e-29 1.287972e-26 21 46194016 46194490 475 - 2.134 1.723 -1.380
ENSG00000160285 E025 496.0965356 0.0014002820 1.291116e-01 2.329386e-01 21 46194491 46194661 171 - 2.619 2.615 -0.016
ENSG00000160285 E026 316.7716875 0.0004355954 5.466935e-02 1.174190e-01 21 46195676 46195756 81 - 2.431 2.414 -0.054
ENSG00000160285 E027 274.6091636 0.0019068627 7.668959e-01 8.492590e-01 21 46196202 46196267 66 - 2.324 2.367 0.145
ENSG00000160285 E028 6.8117812 0.0026035968 1.867575e-01 3.096605e-01 21 46196268 46196371 104 - 0.633 0.856 0.907
ENSG00000160285 E029 332.5960101 0.0027056939 6.127789e-01 7.316492e-01 21 46205836 46205941 106 - 2.428 2.446 0.060
ENSG00000160285 E030 298.7036141 0.0017330571 4.467122e-01 5.881866e-01 21 46206672 46206768 97 - 2.386 2.396 0.035
ENSG00000160285 E031 364.2369373 0.0013277176 6.694903e-02 1.383038e-01 21 46207428 46207577 150 - 2.493 2.476 -0.055
ENSG00000160285 E032 251.7119268 0.0002082202 4.233581e-03 1.379544e-02 21 46208251 46208301 51 - 2.353 2.309 -0.147
ENSG00000160285 E033 292.8727312 0.0001775794 7.323685e-02 1.486957e-01 21 46209554 46209625 72 - 2.396 2.382 -0.044
ENSG00000160285 E034 282.6477289 0.0022625387 2.085789e-01 3.367764e-01 21 46210688 46210744 57 - 2.381 2.372 -0.029
ENSG00000160285 E035 208.0325663 0.0005129522 6.129362e-02 1.288144e-01 21 46213025 46213052 28 - 2.260 2.236 -0.083
ENSG00000160285 E036 303.9767713 0.0017625115 2.238672e-02 5.648019e-02 21 46213738 46213835 98 - 2.433 2.396 -0.123
ENSG00000160285 E037 285.1908558 0.0034521978 1.051458e-01 1.983151e-01 21 46215180 46215298 119 - 2.397 2.371 -0.088
ENSG00000160285 E038 249.3360203 0.0060912753 1.524879e-01 2.650625e-01 21 46215685 46215793 109 - 2.340 2.312 -0.094
ENSG00000160285 E039 316.3382045 0.0057326974 3.185908e-01 4.615579e-01 21 46216389 46216524 136 - 2.425 2.420 -0.016
ENSG00000160285 E040 249.8429400 0.0082438018 5.050068e-01 6.408426e-01 21 46219476 46219572 97 - 2.315 2.321 0.018
ENSG00000160285 E041 275.2969967 0.0013818224 1.982642e-01 3.240466e-01 21 46221854 46221975 122 - 2.364 2.358 -0.020
ENSG00000160285 E042 124.4784931 0.0002746319 2.889358e-01 4.295947e-01 21 46222630 46222662 33 - 2.022 2.013 -0.031
ENSG00000160285 E043 212.0672738 0.0006940806 1.110334e-03 4.337728e-03 21 46222663 46222738 76 - 2.296 2.229 -0.223
ENSG00000160285 E044 4.8481847 0.0705841444 9.972637e-02 1.900556e-01 21 46227319 46227551 233 - 0.880 0.618 -1.062
ENSG00000160285 E045 239.1836594 0.0031692439 1.710385e-02 4.517320e-02 21 46227552 46227690 139 - 2.340 2.286 -0.181
ENSG00000160285 E046 189.6155868 0.0094118831 3.116579e-02 7.421989e-02 21 46228434 46228599 166 - 2.259 2.181 -0.261
ENSG00000160285 E047 18.9297755 0.0304483976 8.488441e-02 1.672223e-01 21 46228600 46228684 85 - 1.340 1.175 -0.581
ENSG00000160285 E048 15.3703628 0.0012911722 3.403393e-04 1.541683e-03 21 46228685 46228731 47 - 1.340 1.043 -1.055
ENSG00000160285 E049 71.6312654 0.0205794778 3.676978e-01 5.120535e-01 21 46228732 46228824 93 - 1.804 1.774 -0.102