ENSG00000160218

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291574 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding protein_coding 15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 5.4255058 3.65880620 6.9638074 0.62468850 0.1924178 0.9266358 0.36227500 0.341733333 0.40023333 0.05850000 6.648171e-01 4.783219e-07 FALSE TRUE
ENST00000380221 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding protein_coding 15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 3.4168954 3.63700758 2.4946712 0.40527587 0.1582071 -0.5420919 0.23744583 0.343900000 0.14293333 -0.20096667 1.685784e-04 4.783219e-07 FALSE TRUE
MSTRG.21422.5 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding   15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 0.4473821 0.05114019 0.9591947 0.03116175 0.1113795 3.9865935 0.02574583 0.004566667 0.05466667 0.05010000 4.783219e-07 4.783219e-07 FALSE TRUE
MSTRG.21422.6 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding   15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 0.9598137 0.02440089 1.1167260 0.02440089 0.5843512 5.0335472 0.05332083 0.002166667 0.06420000 0.06203333 3.784497e-01 4.783219e-07 FALSE TRUE
MSTRG.21422.8 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding   15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 1.5748861 0.07362783 2.7560128 0.07362783 0.4288503 5.0476809 0.09195417 0.006800000 0.15723333 0.15043333 6.566634e-04 4.783219e-07 TRUE TRUE
MSTRG.21422.9 ENSG00000160218 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC10 protein_coding   15.27601 10.64135 17.45729 0.4447023 0.5047189 0.7136196 1.2668748 1.58255417 0.7214314 0.80186549 0.3607221 -1.1225479 0.08782917 0.153033333 0.04020000 -0.11283333 7.986010e-01 4.783219e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160218 E001 0.0000000       21 44012230 44012308 79 +      
ENSG00000160218 E002 0.1451727 0.0433779946 8.218525e-01   21 44012309 44012318 10 + 0.095 0.000 -10.131
ENSG00000160218 E003 0.2903454 0.3429624031 5.002041e-01   21 44012319 44012324 6 + 0.173 0.000 -12.733
ENSG00000160218 E004 7.6464308 0.0734128250 3.057891e-05 1.815672e-04 21 44012325 44012402 78 + 1.114 0.272 -3.784
ENSG00000160218 E005 7.3687708 0.0246026949 1.237209e-06 1.007417e-05 21 44012403 44012407 5 + 1.098 0.271 -3.737
ENSG00000160218 E006 9.0199561 0.1188918603 2.341301e-03 8.280638e-03 21 44012408 44012422 15 + 1.153 0.508 -2.573
ENSG00000160218 E007 10.9868817 0.0092118100 7.912221e-04 3.227845e-03 21 44012423 44012466 44 + 1.190 0.791 -1.483
ENSG00000160218 E008 8.1823526 0.0207327296 7.303874e-02 1.483891e-01 21 44012467 44012473 7 + 1.034 0.792 -0.919
ENSG00000160218 E009 12.4229725 0.0336960492 1.429228e-01 2.520155e-01 21 44012474 44012488 15 + 1.183 0.989 -0.704
ENSG00000160218 E010 29.8201555 0.0070948738 1.132952e-01 2.103269e-01 21 44012489 44012560 72 + 1.527 1.408 -0.410
ENSG00000160218 E011 41.0554411 0.0036386376 5.241503e-01 6.577813e-01 21 44032091 44032172 82 + 1.631 1.595 -0.121
ENSG00000160218 E012 79.3996009 0.0035376431 2.560052e-01 3.929712e-01 21 44037792 44037927 136 + 1.876 1.937 0.204
ENSG00000160218 E013 120.9838491 0.0003806019 8.248256e-01 8.896396e-01 21 44052280 44052476 197 + 2.082 2.082 -0.002
ENSG00000160218 E014 93.2918837 0.0054992220 4.464073e-01 5.878914e-01 21 44055698 44055810 113 + 1.950 1.995 0.150
ENSG00000160218 E015 89.8672676 0.0047317966 1.027527e-01 1.946910e-01 21 44055811 44055893 83 + 1.915 2.000 0.284
ENSG00000160218 E016 87.2983230 0.0003422142 1.524785e-03 5.717256e-03 21 44059103 44059188 86 + 1.883 2.010 0.425
ENSG00000160218 E017 58.1074869 0.0003877928 3.500010e-04 1.580135e-03 21 44059189 44059214 26 + 1.687 1.858 0.577
ENSG00000160218 E018 84.0867585 0.0082713832 6.183532e-19 3.493742e-17 21 44059465 44060262 798 + 1.631 2.163 1.791
ENSG00000160218 E019 5.8992056 0.0027696277 8.492538e-01 9.064204e-01 21 44063053 44063168 116 + 0.839 0.820 -0.074
ENSG00000160218 E020 77.0799472 0.0016786093 1.338219e-01 2.394683e-01 21 44063538 44063785 248 + 1.913 1.854 -0.198
ENSG00000160218 E021 66.0702776 0.0028730602 1.183747e-01 2.176029e-01 21 44074324 44074470 147 + 1.851 1.780 -0.241
ENSG00000160218 E022 81.2700616 0.0021201274 3.498369e-04 1.579494e-03 21 44075039 44075153 115 + 1.967 1.808 -0.534
ENSG00000160218 E023 69.6570327 0.0019099134 2.035842e-03 7.337839e-03 21 44076552 44076628 77 + 1.893 1.750 -0.483
ENSG00000160218 E024 64.6987929 0.0014939381 7.616211e-03 2.281491e-02 21 44077693 44077784 92 + 1.857 1.736 -0.411
ENSG00000160218 E025 0.0000000       21 44079476 44079563 88 +      
ENSG00000160218 E026 82.8631925 0.0003721908 7.376504e-03 2.219629e-02 21 44079564 44079704 141 + 1.956 1.855 -0.340
ENSG00000160218 E027 0.7782011 0.0170857962 8.814658e-01 9.280477e-01 21 44079793 44080014 222 + 0.240 0.270 0.224
ENSG00000160218 E028 80.3998167 0.0067161522 5.299887e-01 6.627072e-01 21 44080015 44080127 113 + 1.917 1.887 -0.102
ENSG00000160218 E029 198.5556234 0.0002098291 4.290735e-01 5.718012e-01 21 44082788 44083302 515 + 2.299 2.286 -0.045
ENSG00000160218 E030 80.2968802 0.0003867952 4.106575e-02 9.300620e-02 21 44084122 44084263 142 + 1.868 1.955 0.294
ENSG00000160218 E031 36.2981210 0.0006236222 7.487072e-01 8.358594e-01 21 44086802 44086805 4 + 1.555 1.580 0.087
ENSG00000160218 E032 87.2063075 0.0003513168 2.906322e-01 4.314584e-01 21 44086806 44086960 155 + 1.953 1.918 -0.115
ENSG00000160218 E033 35.4668402 0.0005661779 3.648925e-03 1.215177e-02 21 44087699 44087703 5 + 1.616 1.443 -0.592
ENSG00000160218 E034 81.6023832 0.0003716557 1.260510e-01 2.286500e-01 21 44087704 44087821 118 + 1.931 1.876 -0.185
ENSG00000160218 E035 89.3439490 0.0004399155 2.008251e-01 3.272155e-01 21 44087822 44087928 107 + 1.966 1.923 -0.144
ENSG00000160218 E036 1.4434817 0.0091320969 2.582209e-01 3.954375e-01 21 44088039 44089484 1446 + 0.297 0.499 1.131
ENSG00000160218 E037 0.1451727 0.0433779946 8.218525e-01   21 44089485 44089500 16 + 0.095 0.000 -12.330
ENSG00000160218 E038 0.1451727 0.0433779946 8.218525e-01   21 44089501 44089580 80 + 0.095 0.000 -12.330
ENSG00000160218 E039 0.1482932 0.0411280748 2.870935e-01   21 44089581 44089700 120 + 0.000 0.155 12.895
ENSG00000160218 E040 0.2998086 0.0292753581 6.925204e-01   21 44089701 44089753 53 + 0.095 0.155 0.808
ENSG00000160218 E041 0.1515154 0.0440829863 8.213135e-01   21 44089754 44089759 6 + 0.095 0.000 -12.329
ENSG00000160218 E042 0.2966881 0.0275148793 3.980569e-01   21 44089760 44089832 73 + 0.174 0.000 -13.345
ENSG00000160218 E043 81.4737480 0.0003753661 2.932238e-01 4.342689e-01 21 44089833 44089933 101 + 1.890 1.938 0.162
ENSG00000160218 E044 2.5809018 0.0057390433 6.568234e-01 7.662966e-01 21 44091753 44091922 170 + 0.569 0.499 -0.326
ENSG00000160218 E045 92.9501923 0.0010892128 9.505051e-01 9.730256e-01 21 44091923 44092049 127 + 1.962 1.966 0.012
ENSG00000160218 E046 106.6745952 0.0075426690 4.575583e-01 5.978842e-01 21 44094063 44094233 171 + 2.004 2.048 0.147
ENSG00000160218 E047 0.1451727 0.0433779946 8.218525e-01   21 44096580 44096604 25 + 0.095 0.000 -12.330
ENSG00000160218 E048 2.4304175 0.0141622730 7.941171e-01 8.684529e-01 21 44096605 44096713 109 + 0.507 0.555 0.227
ENSG00000160218 E049 0.0000000       21 44096714 44098356 1643 +      
ENSG00000160218 E050 42.9144804 0.0064706345 1.394708e-01 2.473028e-01 21 44098357 44098534 178 + 1.586 1.687 0.343
ENSG00000160218 E051 9.7507787 0.0022123576 2.325347e-01 3.654638e-01 21 44102778 44102972 195 + 0.971 1.101 0.478
ENSG00000160218 E052 0.7373013 0.1131564611 3.700425e-01 5.144528e-01 21 44103293 44103296 4 + 0.173 0.356 1.371
ENSG00000160218 E053 12.9291789 0.0014815257 7.321294e-04 3.014884e-03 21 44103297 44106552 3256 + 0.982 1.300 1.140