ENSG00000160216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291572 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding protein_coding 29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 11.1096260 13.402815 11.7549753 1.7138921 0.38191512 -0.18911379 0.37116667 0.43980000 0.37293333 -0.066866667 2.709085e-01 3.386319e-38 FALSE TRUE
ENST00000398061 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding protein_coding 29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 1.2173650 2.691325 0.3837715 0.6793844 0.38377152 -2.77823659 0.04412500 0.08770000 0.01286667 -0.074833333 7.771191e-02 3.386319e-38 FALSE TRUE
ENST00000457068 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding protein_coding 29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 4.0927013 0.000000 6.0323616 0.0000000 0.68870601 9.23896871 0.13959167 0.00000000 0.19043333 0.190433333 3.386319e-38 3.386319e-38 FALSE FALSE
ENST00000479117 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding processed_transcript 29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 0.7178081 1.464479 0.0000000 0.8553472 0.00000000 -7.20406170 0.02765833 0.05350000 0.00000000 -0.053500000 1.690342e-01 3.386319e-38 FALSE TRUE
ENST00000484865 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding retained_intron 29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 2.7192260 1.799015 3.4470309 0.2835980 0.08934206 0.93432950 0.09374583 0.05896667 0.10933333 0.050366667 1.212477e-03 3.386319e-38 FALSE TRUE
MSTRG.21419.1 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding   29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 2.0728697 2.643858 2.7423515 0.7528183 0.21656474 0.05257338 0.06669167 0.08530000 0.08696667 0.001666667 9.591929e-01 3.386319e-38 FALSE FALSE
MSTRG.21419.6 ENSG00000160216 HEK293_OSMI2_2hA HEK293_TMG_2hB AGPAT3 protein_coding   29.27601 30.25717 31.55692 2.327316 1.192575 0.06065969 1.6700301 3.983020 1.3398703 0.5441000 0.90520557 -1.56465951 0.05858333 0.13316667 0.04363333 -0.089533333 4.020785e-01 3.386319e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160216 E001 1.5479712 0.0090004037 1.574544e-02 4.216211e-02 21 43865191 43865206 16 + 0.581 0.205 -2.224
ENSG00000160216 E002 3.4020686 0.0044410325 2.182851e-05 1.341251e-04 21 43865207 43865222 16 + 0.886 0.280 -2.887
ENSG00000160216 E003 4.2846443 0.0036201406 2.500112e-06 1.904841e-05 21 43865223 43865229 7 + 0.975 0.343 -2.809
ENSG00000160216 E004 6.0821627 0.0026170528 3.889990e-09 5.169381e-08 21 43865230 43865236 7 + 1.124 0.399 -3.032
ENSG00000160216 E005 8.4687910 0.0076413494 3.238166e-12 7.309195e-11 21 43865237 43865239 3 + 1.269 0.448 -3.282
ENSG00000160216 E006 43.2148739 0.0023901263 6.319487e-07 5.479212e-06 21 43865240 43865345 106 + 1.750 1.534 -0.735
ENSG00000160216 E007 3.3494482 0.0178301910 9.453471e-01 9.696804e-01 21 43866457 43866618 162 + 0.620 0.663 0.185
ENSG00000160216 E008 2.7227625 0.0187039571 9.412473e-01 9.670668e-01 21 43866619 43866665 47 + 0.539 0.602 0.286
ENSG00000160216 E009 7.3555711 0.0368963558 1.852876e-01 3.078599e-01 21 43867139 43867241 103 + 0.975 0.850 -0.473
ENSG00000160216 E010 9.6292854 0.0314098013 4.689940e-01 6.083125e-01 21 43867242 43867346 105 + 1.021 0.995 -0.095
ENSG00000160216 E011 1.2136029 0.0108647759 4.606128e-01 6.006120e-01 21 43867493 43867594 102 + 0.231 0.399 1.098
ENSG00000160216 E012 0.5514428 0.0196561105 1.430031e-01 2.521243e-01 21 43867677 43867746 70 + 0.000 0.280 14.987
ENSG00000160216 E013 2.8558175 0.0401577269 2.187036e-01 3.488603e-01 21 43882504 43882543 40 + 0.655 0.494 -0.731
ENSG00000160216 E014 4.3512460 0.0041411888 2.412745e-01 3.756809e-01 21 43882544 43882615 72 + 0.773 0.664 -0.446
ENSG00000160216 E015 0.4439371 0.0215538894 4.581546e-02 1.016918e-01 21 43903891 43903956 66 + 0.313 0.000 -15.812
ENSG00000160216 E016 59.9598757 0.0027423554 1.861764e-03 6.794690e-03 21 43903957 43904019 63 + 1.825 1.734 -0.307
ENSG00000160216 E017 0.0000000       21 43916272 43916421 150 +      
ENSG00000160216 E018 1.2899771 0.0321894129 9.760391e-01 9.890333e-01 21 43924209 43924332 124 + 0.313 0.345 0.201
ENSG00000160216 E019 0.1482932 0.0420749073 6.451377e-01   21 43925008 43925451 444 + 0.000 0.114 13.115
ENSG00000160216 E020 0.1482932 0.0420749073 6.451377e-01   21 43946930 43946949 20 + 0.000 0.114 13.115
ENSG00000160216 E021 0.1482932 0.0420749073 6.451377e-01   21 43946950 43947005 56 + 0.000 0.114 13.115
ENSG00000160216 E022 0.0000000       21 43947006 43947009 4 +      
ENSG00000160216 E023 0.0000000       21 43947010 43947058 49 +      
ENSG00000160216 E024 0.0000000       21 43948154 43948273 120 +      
ENSG00000160216 E025 0.0000000       21 43948274 43948329 56 +      
ENSG00000160216 E026 0.0000000       21 43948330 43948342 13 +      
ENSG00000160216 E027 0.0000000       21 43950687 43950712 26 +      
ENSG00000160216 E028 0.1482932 0.0420749073 6.451377e-01   21 43950713 43950874 162 + 0.000 0.114 13.115
ENSG00000160216 E029 0.2214452 0.0387560350 6.434299e-01   21 43954548 43954549 2 + 0.000 0.115 13.154
ENSG00000160216 E030 3.1698056 0.0080172978 6.425958e-01 7.553662e-01 21 43954550 43955242 693 + 0.539 0.664 0.553
ENSG00000160216 E031 135.5978668 0.0013222162 4.346312e-02 9.740182e-02 21 43959634 43959747 114 + 2.124 2.123 -0.001
ENSG00000160216 E032 118.0541525 0.0035171455 5.114872e-01 6.465110e-01 21 43959748 43959782 35 + 2.037 2.081 0.147
ENSG00000160216 E033 97.6185938 0.0003502377 6.063526e-02 1.277019e-01 21 43959783 43959788 6 + 1.981 1.981 0.000
ENSG00000160216 E034 175.5373756 0.0026671141 2.404464e-02 5.990748e-02 21 43959789 43959859 71 + 2.241 2.231 -0.033
ENSG00000160216 E035 39.2878623 0.0005988668 4.734992e-02 1.044528e-01 21 43960632 43960779 148 + 1.618 1.573 -0.150
ENSG00000160216 E036 69.4707853 0.0003876910 1.324669e-05 8.553614e-05 21 43964929 43967868 2940 + 1.900 1.783 -0.395
ENSG00000160216 E037 7.5975553 0.0021685034 5.471476e-02 1.174979e-01 21 43967869 43967945 77 + 1.006 0.847 -0.602
ENSG00000160216 E038 314.8236285 0.0008866858 3.293515e-04 1.498323e-03 21 43967946 43968115 170 + 2.498 2.482 -0.052
ENSG00000160216 E039 302.3903382 0.0015244495 6.070248e-02 1.278165e-01 21 43969118 43969279 162 + 2.460 2.481 0.068
ENSG00000160216 E040 290.4458929 0.0016675704 3.451594e-01 4.892388e-01 21 43970653 43970806 154 + 2.430 2.474 0.148
ENSG00000160216 E041 6.9440806 0.0024244000 9.862867e-04 3.911952e-03 21 43970807 43970880 74 + 0.539 1.039 2.013
ENSG00000160216 E042 123.3733842 0.0037711475 5.562133e-02 1.190466e-01 21 43971388 43971402 15 + 2.094 2.082 -0.040
ENSG00000160216 E043 214.6712038 0.0001902340 1.413420e-05 9.066746e-05 21 43971403 43971490 88 + 2.346 2.309 -0.124
ENSG00000160216 E044 184.6414533 0.0002059398 5.676730e-03 1.775795e-02 21 43978046 43978121 76 + 2.262 2.258 -0.014
ENSG00000160216 E045 319.4874854 0.0004833503 3.465693e-05 2.028627e-04 21 43980989 43981187 199 + 2.508 2.487 -0.068
ENSG00000160216 E046 17.2789563 0.0014012872 4.867343e-03 1.556083e-02 21 43981188 43981412 225 + 1.338 1.172 -0.583
ENSG00000160216 E047 3222.0441859 0.0030493900 4.018575e-08 4.418497e-07 21 43982304 43987592 5289 + 3.410 3.556 0.487