ENSG00000160214

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000497547 ENSG00000160214 HEK293_OSMI2_2hA HEK293_TMG_2hB RRP1 protein_coding protein_coding 127.0685 203.3767 87.65716 8.181536 0.6745871 -1.214117 32.176578 65.29374 15.781408 1.0717106 1.1027767 -2.048026 0.22878750 0.3220000 0.17993333 -0.142066667 5.984942e-07 9.60488e-11 FALSE TRUE
MSTRG.21416.4 ENSG00000160214 HEK293_OSMI2_2hA HEK293_TMG_2hB RRP1 protein_coding   127.0685 203.3767 87.65716 8.181536 0.6745871 -1.214117 9.636104 13.78453 6.682187 0.8703414 0.7559829 -1.043547 0.07566667 0.0680000 0.07613333 0.008133333 7.879249e-01 9.60488e-11 FALSE TRUE
MSTRG.21416.9 ENSG00000160214 HEK293_OSMI2_2hA HEK293_TMG_2hB RRP1 protein_coding   127.0685 203.3767 87.65716 8.181536 0.6745871 -1.214117 73.068930 110.79616 55.357298 6.9849140 0.4834096 -1.000932 0.58915000 0.5438667 0.63156667 0.087700000 5.195725e-03 9.60488e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160214 E001 1.1907016 3.609846e-01 2.073446e-01 3.353207e-01 21 43776299 43776336 38 + 0.506 0.237 -1.604
ENSG00000160214 E002 0.1817044 4.011469e-02 1.000000e+00   21 43789513 43789518 6 + 0.000 0.076 7.798
ENSG00000160214 E003 0.4031496 2.505040e-02 6.983375e-01 7.983125e-01 21 43789519 43789531 13 + 0.000 0.142 8.800
ENSG00000160214 E004 2.1443490 7.639456e-03 9.784731e-01 9.906499e-01 21 43789532 43789541 10 + 0.424 0.437 0.069
ENSG00000160214 E005 2.5860961 2.270488e-02 2.385143e-01 3.724146e-01 21 43789542 43789542 1 + 0.634 0.437 -0.928
ENSG00000160214 E006 28.3753028 8.764640e-03 6.153303e-01 7.336262e-01 21 43789543 43789558 16 + 1.341 1.398 0.197
ENSG00000160214 E007 66.8167433 3.728987e-04 7.791058e-01 8.579457e-01 21 43789559 43789576 18 + 1.753 1.751 -0.005
ENSG00000160214 E008 767.1445771 2.773554e-04 1.612940e-03 6.001858e-03 21 43789577 43789695 119 + 2.833 2.795 -0.128
ENSG00000160214 E009 863.2385097 1.507886e-04 2.872958e-04 1.328273e-03 21 43789696 43789762 67 + 2.886 2.846 -0.134
ENSG00000160214 E010 1.2692660 2.095199e-01 8.826246e-02 1.724692e-01 21 43790493 43791015 523 + 0.576 0.197 -2.271
ENSG00000160214 E011 1.6357821 1.707594e-01 3.904357e-01 5.344003e-01 21 43791016 43791056 41 + 0.506 0.331 -0.952
ENSG00000160214 E012 989.0087033 2.750403e-04 9.592302e-02 1.842699e-01 21 43791350 43791432 83 + 2.924 2.912 -0.038
ENSG00000160214 E013 855.7350653 6.578502e-04 4.183710e-02 9.442717e-02 21 43792672 43792729 58 + 2.870 2.847 -0.078
ENSG00000160214 E014 25.6853926 7.249236e-04 1.990343e-14 6.266654e-13 21 43792730 43792930 201 + 1.684 1.172 -1.773
ENSG00000160214 E015 46.1709227 4.968904e-04 1.851295e-20 1.249011e-18 21 43792931 43793318 388 + 1.908 1.431 -1.619
ENSG00000160214 E016 1102.3822707 1.086805e-03 7.101238e-02 1.450201e-01 21 43793319 43793404 86 + 2.979 2.958 -0.069
ENSG00000160214 E017 2.0586264 9.807986e-03 2.262531e-01 3.578976e-01 21 43793405 43793419 15 + 0.574 0.371 -1.030
ENSG00000160214 E018 1008.1324275 8.790601e-04 4.532089e-02 1.007783e-01 21 43795189 43795250 62 + 2.942 2.919 -0.077
ENSG00000160214 E019 5.1104295 3.450372e-03 3.530069e-02 8.222808e-02 21 43797361 43797421 61 + 0.912 0.631 -1.129
ENSG00000160214 E020 551.6792860 1.825570e-04 4.431158e-01 5.846825e-01 21 43797422 43797425 4 + 2.662 2.661 -0.004
ENSG00000160214 E021 1369.2258853 1.145089e-04 9.905630e-04 3.926089e-03 21 43797426 43797551 126 + 3.076 3.051 -0.084
ENSG00000160214 E022 1127.6850117 9.077244e-05 2.609479e-04 1.220456e-03 21 43797631 43797695 65 + 2.998 2.965 -0.108
ENSG00000160214 E023 1494.0653025 1.368035e-04 6.330791e-02 1.322165e-01 21 43797907 43798049 143 + 3.101 3.093 -0.026
ENSG00000160214 E024 912.3147180 1.022526e-04 6.577430e-02 1.363245e-01 21 43798050 43798100 51 + 2.849 2.888 0.131
ENSG00000160214 E025 1170.7910698 7.821348e-05 4.335667e-04 1.903588e-03 21 43799570 43799649 80 + 2.943 3.001 0.192
ENSG00000160214 E026 1245.4022335 5.138272e-04 1.832679e-01 3.053047e-01 21 43800517 43800614 98 + 2.988 3.023 0.115
ENSG00000160214 E027 767.1209177 1.467380e-04 1.169345e-02 3.280565e-02 21 43800862 43800881 20 + 2.763 2.816 0.178
ENSG00000160214 E028 36.0150649 3.966839e-03 4.239056e-11 7.961499e-10 21 43800882 43800922 41 + 1.777 1.357 -1.437
ENSG00000160214 E029 27.5964957 6.114893e-03 3.592117e-04 1.615813e-03 21 43801657 43801722 66 + 1.572 1.309 -0.908
ENSG00000160214 E030 1244.4280593 2.419370e-03 3.645669e-03 1.214307e-02 21 43802274 43802387 114 + 2.945 3.035 0.296
ENSG00000160214 E031 2832.0011294 1.395055e-03 3.313659e-07 3.038247e-06 21 43803512 43805293 1782 + 3.289 3.395 0.350
ENSG00000160214 E032 8.2970787 2.302898e-03 1.682154e-05 1.061202e-04 21 43820526 43820679 154 + 1.215 0.749 -1.740