ENSG00000160211

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393562 ENSG00000160211 HEK293_OSMI2_2hA HEK293_TMG_2hB G6PD protein_coding protein_coding 75.25195 131.8323 37.24646 9.054945 0.9229565 -1.823251 31.046450 53.979651 14.166735 7.7869522 0.5604104 -1.9291576 0.4010333 0.40486667 0.3815000 -0.02336667 0.87102210 6.165142e-11 FALSE TRUE
ENST00000393564 ENSG00000160211 HEK293_OSMI2_2hA HEK293_TMG_2hB G6PD protein_coding protein_coding 75.25195 131.8323 37.24646 9.054945 0.9229565 -1.823251 26.758147 55.973116 11.932816 0.9592992 0.5069084 -2.2288488 0.3320917 0.42843333 0.3200667 -0.10836667 0.03595484 6.165142e-11 FALSE TRUE
ENST00000440967 ENSG00000160211 HEK293_OSMI2_2hA HEK293_TMG_2hB G6PD protein_coding protein_coding 75.25195 131.8323 37.24646 9.054945 0.9229565 -1.823251 6.699031 7.656743 5.637975 3.9285388 0.5407462 -0.4408802 0.1070208 0.05443333 0.1511667 0.09673333 0.60444389 6.165142e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160211 E001 0.0000000       X 154517825 154517829 5 -      
ENSG00000160211 E002 0.0000000       X 154517830 154517839 10 -      
ENSG00000160211 E003 3.4642415 0.0709109405 1.689727e-01 2.868505e-01 X 154517840 154518296 457 - 0.760 0.516 -1.062
ENSG00000160211 E004 1.5135132 0.0093312433 1.423608e-02 3.876200e-02 X 154518297 154518448 152 - 0.643 0.210 -2.447
ENSG00000160211 E005 1.8015773 0.0081112994 4.613439e-01 6.013170e-01 X 154518449 154518631 183 - 0.225 0.381 1.044
ENSG00000160211 E006 2.8493850 0.0165275991 1.116019e-01 2.079025e-01 X 154531390 154531390 1 - 0.706 0.433 -1.253
ENSG00000160211 E007 20.9085023 0.0414291705 6.384814e-01 7.521163e-01 X 154531391 154531391 1 - 1.144 1.223 0.283
ENSG00000160211 E008 39.3845780 0.0350446917 8.515281e-01 9.079366e-01 X 154531392 154531397 6 - 1.440 1.480 0.138
ENSG00000160211 E009 1086.2389534 0.0017783420 2.020515e-12 4.715208e-11 X 154531398 154531999 602 - 2.742 2.925 0.607
ENSG00000160211 E010 347.7728292 0.0012109461 2.777744e-07 2.587957e-06 X 154532000 154532082 83 - 2.258 2.429 0.571
ENSG00000160211 E011 248.7025982 0.0012993965 1.070071e-01 2.011148e-01 X 154532083 154532090 8 - 2.208 2.270 0.208
ENSG00000160211 E012 6.4312709 0.0027281006 2.032661e-01 3.303079e-01 X 154532091 154532187 97 - 0.571 0.788 0.918
ENSG00000160211 E013 523.9757592 0.0026720959 6.574518e-02 1.362806e-01 X 154532188 154532280 93 - 2.528 2.594 0.222
ENSG00000160211 E014 597.3454375 0.0020489025 7.287623e-02 1.481239e-01 X 154532386 154532462 77 - 2.591 2.650 0.196
ENSG00000160211 E015 1085.0676185 0.0009732661 8.221407e-03 2.434539e-02 X 154532567 154532802 236 - 2.849 2.909 0.198
ENSG00000160211 E016 11.0866054 0.0017305319 4.448681e-02 9.926497e-02 X 154532803 154532941 139 - 1.144 0.920 -0.820
ENSG00000160211 E017 604.6245499 0.0001172204 1.143267e-02 3.219305e-02 X 154532942 154533033 92 - 2.596 2.651 0.181
ENSG00000160211 E018 624.2666713 0.0001479507 4.733360e-01 6.122949e-01 X 154533034 154533128 95 - 2.642 2.661 0.062
ENSG00000160211 E019 9.3572987 0.0028298565 8.088939e-04 3.290090e-03 X 154533129 154533316 188 - 1.184 0.799 -1.430
ENSG00000160211 E020 13.0294459 0.0013769960 1.192401e-06 9.741946e-06 X 154533317 154533491 175 - 1.370 0.895 -1.710
ENSG00000160211 E021 8.1696355 0.0025096304 3.145208e-06 2.341994e-05 X 154533492 154533568 77 - 1.238 0.703 -2.011
ENSG00000160211 E022 7.3665676 0.0023646373 2.006537e-04 9.666295e-04 X 154533569 154533575 7 - 1.144 0.690 -1.730
ENSG00000160211 E023 618.7304980 0.0001100742 6.324122e-02 1.321108e-01 X 154533576 154533641 66 - 2.678 2.648 -0.100
ENSG00000160211 E024 494.6408073 0.0003406976 3.576293e-01 5.020511e-01 X 154533642 154533669 28 - 2.571 2.556 -0.051
ENSG00000160211 E025 2.8773995 0.0120120826 3.317844e-03 1.119941e-02 X 154533670 154533807 138 - 0.853 0.380 -2.128
ENSG00000160211 E026 356.7340138 0.0017500638 4.296682e-01 5.723642e-01 X 154534035 154534035 1 - 2.433 2.414 -0.061
ENSG00000160211 E027 839.3927511 0.0001063413 2.444173e-01 3.793710e-01 X 154534036 154534160 125 - 2.798 2.784 -0.047
ENSG00000160211 E028 13.1842967 0.0037667562 2.313302e-04 1.097129e-03 X 154534161 154534193 33 - 1.316 0.944 -1.342
ENSG00000160211 E029 984.1539707 0.0001284572 2.772523e-02 6.747244e-02 X 154534338 154534496 159 - 2.878 2.849 -0.094
ENSG00000160211 E030 44.0274037 0.0004932526 3.422319e-01 4.862294e-01 X 154534497 154534499 3 - 1.569 1.509 -0.203
ENSG00000160211 E031 4.1297972 0.0139402581 9.541133e-02 1.835084e-01 X 154535075 154535167 93 - 0.809 0.544 -1.124
ENSG00000160211 E032 725.9500247 0.0001587517 4.030552e-04 1.786393e-03 X 154535168 154535241 74 - 2.769 2.712 -0.188
ENSG00000160211 E033 934.6240085 0.0011128073 2.631594e-02 6.458039e-02 X 154535242 154535385 144 - 2.866 2.827 -0.131
ENSG00000160211 E034 2.2068178 0.0068135633 6.814625e-01 7.851380e-01 X 154535726 154535936 211 - 0.483 0.408 -0.390
ENSG00000160211 E035 403.8672032 0.0009826271 1.983365e-01 3.241367e-01 X 154535937 154535953 17 - 2.494 2.465 -0.097
ENSG00000160211 E036 603.8377850 0.0011855895 5.681501e-01 6.948468e-01 X 154535954 154536045 92 - 2.650 2.642 -0.024
ENSG00000160211 E037 1.7617373 0.3887649147 6.932678e-01 7.943240e-01 X 154536137 154536140 4 - 0.483 0.342 -0.764
ENSG00000160211 E038 397.0956139 0.0018887275 4.419495e-01 5.836110e-01 X 154536141 154536178 38 - 2.476 2.459 -0.057
ENSG00000160211 E039 1.2544010 0.0107524365 7.756614e-01 8.554804e-01 X 154545751 154546035 285 - 0.225 0.287 0.458
ENSG00000160211 E040 552.9838862 0.0041704336 3.945466e-02 9.002247e-02 X 154546036 154546159 124 - 2.660 2.595 -0.214
ENSG00000160211 E041 260.4885296 0.0063462054 1.512995e-02 4.078074e-02 X 154546160 154546163 4 - 2.366 2.261 -0.350
ENSG00000160211 E042 0.9170165 0.0152464546 2.689910e-01 4.074580e-01 X 154546724 154546788 65 - 0.373 0.167 -1.538
ENSG00000160211 E043 201.0882323 0.0061733378 1.523651e-02 4.102313e-02 X 154546789 154546961 173 - 2.257 2.148 -0.364
ENSG00000160211 E044 3.0434963 0.0946232356 1.757525e-01 2.956682e-01 X 154547026 154547062 37 - 0.705 0.441 -1.212
ENSG00000160211 E045 7.7310946 0.0023332552 9.432022e-04 3.765395e-03 X 154547063 154547467 405 - 1.122 0.717 -1.540
ENSG00000160211 E046 108.7907232 0.0040280473 1.358202e-02 3.726538e-02 X 154547468 154547572 105 - 2.001 1.880 -0.407