ENSG00000160208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340648 ENSG00000160208 HEK293_OSMI2_2hA HEK293_TMG_2hB RRP1B protein_coding protein_coding 73.4988 69.54583 91.3348 2.207399 2.30184 0.3931512 70.8151987 63.197354 89.83546 4.638654 2.324908 0.5073533 0.9596458 0.90636667 0.9835667 0.07720000 0.04678844 0.04678844 FALSE  
MSTRG.21412.1 ENSG00000160208 HEK293_OSMI2_2hA HEK293_TMG_2hB RRP1B protein_coding   73.4988 69.54583 91.3348 2.207399 2.30184 0.3931512 0.6901097 4.206296 0.00000 2.336979 0.000000 -8.7198323 0.0103875 0.06266667 0.0000000 -0.06266667 0.14232406 0.04678844 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160208 E001 1.687828 0.1212850317 5.945452e-02 1.257015e-01 21 43658821 43658961 141 + 0.172 0.616 2.690
ENSG00000160208 E002 3.954647 0.0039324622 7.854781e-05 4.211167e-04 21 43659559 43659559 1 + 0.834 0.272 -2.740
ENSG00000160208 E003 345.921940 0.0010685392 1.456246e-27 1.994805e-25 21 43659560 43659794 235 + 2.585 2.433 -0.504
ENSG00000160208 E004 196.577553 0.0016844267 3.506053e-20 2.281729e-18 21 43669884 43669886 3 + 2.350 2.168 -0.607
ENSG00000160208 E005 370.500587 0.0020695730 1.066019e-15 4.008618e-14 21 43669887 43669966 80 + 2.601 2.493 -0.359
ENSG00000160208 E006 410.889026 0.0013085492 9.663627e-18 4.760128e-16 21 43672308 43672365 58 + 2.639 2.550 -0.297
ENSG00000160208 E007 495.733432 0.0016214108 1.113295e-14 3.637014e-13 21 43673870 43673955 86 + 2.713 2.644 -0.231
ENSG00000160208 E008 449.774530 0.0002612058 8.193924e-21 5.783585e-19 21 43674636 43674697 62 + 2.663 2.616 -0.157
ENSG00000160208 E009 565.633417 0.0028516408 1.249996e-06 1.017086e-05 21 43675034 43675163 130 + 2.752 2.733 -0.062
ENSG00000160208 E010 474.520166 0.0042096776 7.456252e-08 7.761770e-07 21 43676272 43676336 65 + 2.693 2.629 -0.212
ENSG00000160208 E011 769.335710 0.0005082607 1.029328e-20 7.198340e-19 21 43676733 43676914 182 + 2.889 2.860 -0.097
ENSG00000160208 E012 583.545434 0.0001421320 3.735945e-23 3.365495e-21 21 43683279 43683373 95 + 2.769 2.740 -0.098
ENSG00000160208 E013 617.815660 0.0027857626 1.457876e-07 1.435053e-06 21 43684553 43684650 98 + 2.793 2.766 -0.088
ENSG00000160208 E014 404.443734 0.0036777031 1.200395e-07 1.201454e-06 21 43685770 43685789 20 + 2.620 2.565 -0.185
ENSG00000160208 E015 23.028026 0.0008049021 1.906827e-06 1.490118e-05 21 43686132 43686803 672 + 1.454 1.211 -0.846
ENSG00000160208 E016 662.413024 0.0025454485 5.614419e-07 4.919452e-06 21 43686804 43686935 132 + 2.818 2.805 -0.043
ENSG00000160208 E017 1506.419757 0.0008193481 2.248780e-03 7.994909e-03 21 43687516 43688240 725 + 3.136 3.216 0.264
ENSG00000160208 E018 3.667229 0.0341401718 9.535797e-01 9.749321e-01 21 43688241 43688245 5 + 0.619 0.728 0.460
ENSG00000160208 E019 605.561346 0.0001479265 1.828292e-03 6.690891e-03 21 43690288 43690440 153 + 2.742 2.821 0.263
ENSG00000160208 E020 470.971547 0.0001405639 1.662433e-01 2.833164e-01 21 43691439 43691502 64 + 2.622 2.724 0.342
ENSG00000160208 E021 6860.903939 0.0042330667 4.105197e-22 3.310844e-20 21 43693190 43696079 2890 + 3.677 3.985 1.023