ENSG00000160201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291552 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding protein_coding 16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 4.278380 6.0417052 4.375669 1.65991638 1.3240042 -0.4645448 0.25376667 0.41403333 0.20840000 -0.2056333 3.492927e-01 3.788969e-11 FALSE TRUE
ENST00000380276 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding protein_coding 16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 1.210534 1.6591780 0.917648 0.85912848 0.5100648 -0.8474884 0.07239583 0.11353333 0.04163333 -0.0719000 8.624373e-01 3.788969e-11 FALSE TRUE
ENST00000468039 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding retained_intron 16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 1.264669 0.0000000 2.861923 0.00000000 0.5692074 8.1658734 0.07507083 0.00000000 0.14883333 0.1488333 3.788969e-11 3.788969e-11   FALSE
ENST00000478282 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding retained_intron 16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 2.024742 1.2166988 2.434918 0.17854395 0.1512241 0.9950049 0.12818750 0.08246667 0.12376667 0.0413000 3.869787e-01 3.788969e-11 TRUE FALSE
ENST00000496462 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding retained_intron 16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 2.591351 0.9581817 4.155672 0.08886533 0.4835748 2.1051997 0.15822083 0.06503333 0.20943333 0.1444000 1.084609e-04 3.788969e-11 FALSE FALSE
MSTRG.21401.11 ENSG00000160201 HEK293_OSMI2_2hA HEK293_TMG_2hB U2AF1 protein_coding   16.46787 14.73111 20.21488 0.3407971 1.757792 0.4562859 3.684576 4.3782844 2.945579 2.40936145 1.5810230 -0.5702162 0.22693333 0.29300000 0.14426667 -0.1487333 9.096208e-01 3.788969e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160201 E001 0.0000000       21 43092048 43092192 145 -      
ENSG00000160201 E002 0.0000000       21 43092193 43092697 505 -      
ENSG00000160201 E003 0.0000000       21 43092698 43092955 258 -      
ENSG00000160201 E004 0.0000000       21 43092956 43093189 234 -      
ENSG00000160201 E005 0.2214452 0.0400626769 3.530761e-01   21 43093190 43093249 60 - 0.000 0.144 9.892
ENSG00000160201 E006 0.0000000       21 43093250 43093893 644 -      
ENSG00000160201 E007 3.7028196 0.0045579491 1.963010e-01 3.215926e-01 21 43093894 43094470 577 - 0.747 0.574 -0.739
ENSG00000160201 E008 1.8906411 0.0075445115 5.425397e-01 6.732685e-01 21 43094471 43094563 93 - 0.499 0.410 -0.459
ENSG00000160201 E009 3.0301495 0.0052604842 3.566168e-01 5.010057e-01 21 43094655 43094788 134 - 0.654 0.526 -0.573
ENSG00000160201 E010 12.6292258 0.0458279793 9.969275e-01 1.000000e+00 21 43094789 43095437 649 - 1.119 1.153 0.121
ENSG00000160201 E011 10.6422384 0.0019307993 7.439342e-01 8.324194e-01 21 43095438 43095533 96 - 1.041 1.093 0.190
ENSG00000160201 E012 5.6485123 0.0030219008 9.135080e-01 9.491968e-01 21 43095534 43095536 3 - 0.806 0.838 0.127
ENSG00000160201 E013 2.6645507 0.0060115439 1.139285e-01 2.112480e-01 21 43095537 43095693 157 - 0.654 0.410 -1.159
ENSG00000160201 E014 6.4148541 0.0031230919 3.308379e-02 7.797687e-02 21 43095694 43095701 8 - 0.726 1.001 1.065
ENSG00000160201 E015 6.8921152 0.0027438348 6.861424e-02 1.410684e-01 21 43095702 43095743 42 - 0.787 1.018 0.877
ENSG00000160201 E016 0.1515154 0.0431442757 6.663395e-01   21 43095744 43096390 647 - 0.104 0.000 -11.879
ENSG00000160201 E017 30.6617599 0.0008021709 1.944513e-10 3.264063e-09 21 43097622 43100452 2831 - 1.632 1.262 -1.275
ENSG00000160201 E018 8.9475168 0.0020333110 6.521626e-04 2.723531e-03 21 43100453 43100519 67 - 0.787 1.168 1.422
ENSG00000160201 E019 0.0000000       21 43100520 43100576 57 -      
ENSG00000160201 E020 0.0000000       21 43100577 43100614 38 -      
ENSG00000160201 E021 0.0000000       21 43100615 43101365 751 -      
ENSG00000160201 E022 4.2673831 0.0338698973 2.566395e-01 3.936202e-01 21 43101366 43101432 67 - 0.627 0.813 0.765
ENSG00000160201 E023 9.2625009 0.0806848295 2.552050e-05 1.544017e-04 21 43101433 43104314 2882 - 1.216 0.467 -2.998
ENSG00000160201 E024 21.0688860 0.0215765880 4.813488e-03 1.541258e-02 21 43104315 43104402 88 - 1.199 1.475 0.962
ENSG00000160201 E025 5.6949208 0.0030389172 2.096731e-07 2.002316e-06 21 43104403 43105252 850 - 1.030 0.252 -3.628
ENSG00000160201 E026 36.0783823 0.0243995167 6.804452e-04 2.827618e-03 21 43107451 43107649 199 - 1.420 1.699 0.952