ENSG00000160199

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291547 ENSG00000160199 HEK293_OSMI2_2hA HEK293_TMG_2hB PKNOX1 protein_coding protein_coding 8.963388 5.357424 13.89616 0.4948719 1.680184 1.373422 5.401672 4.4434108 7.5322829 0.51139689 0.1718941 0.7600906 0.65735000 0.82723333 0.55900000 -0.26823333 0.01085172 0.01085172 FALSE TRUE
ENST00000418336 ENSG00000160199 HEK293_OSMI2_2hA HEK293_TMG_2hB PKNOX1 protein_coding retained_intron 8.963388 5.357424 13.89616 0.4948719 1.680184 1.373422 2.670290 0.3298853 5.1798267 0.32988527 1.1397457 3.9325666 0.22886667 0.06486667 0.36443333 0.29956667 0.07487358 0.01085172   FALSE
ENST00000474336 ENSG00000160199 HEK293_OSMI2_2hA HEK293_TMG_2hB PKNOX1 protein_coding retained_intron 8.963388 5.357424 13.89616 0.4948719 1.680184 1.373422 0.483480 0.2588739 0.5504985 0.05553518 0.5504985 1.0597810 0.05665417 0.05023333 0.03196667 -0.01826667 0.34617544 0.01085172   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160199 E001 0.4407149 0.0217681645 9.201979e-01 9.535865e-01 21 42974510 42974534 25 + 0.177 0.152 -0.265
ENSG00000160199 E002 3.0718675 0.0054248789 2.386429e-01 3.725695e-01 21 42974535 42974561 27 + 0.680 0.491 -0.849
ENSG00000160199 E003 31.5770858 0.0007708241 3.035364e-04 1.393688e-03 21 42974562 42974661 100 + 1.595 1.359 -0.812
ENSG00000160199 E004 26.6483687 0.0008333876 2.321448e-04 1.100567e-03 21 42974662 42974664 3 + 1.532 1.270 -0.905
ENSG00000160199 E005 0.6759915 0.5454265048 8.758484e-01 9.242676e-01 21 42975185 42975275 91 + 0.246 0.157 -0.811
ENSG00000160199 E006 0.4439371 0.0215597212 2.035125e-01 3.306023e-01 21 43000799 43000954 156 + 0.245 0.000 -11.750
ENSG00000160199 E007 1.2177701 0.0111261218 4.859762e-01 6.237906e-01 21 43003889 43004321 433 + 0.303 0.428 0.734
ENSG00000160199 E008 0.9609246 0.0130716712 8.323869e-01 8.949823e-01 21 43004322 43004325 4 + 0.303 0.265 -0.263
ENSG00000160199 E009 68.2176411 0.0028519822 3.677343e-05 2.138180e-04 21 43004326 43004432 107 + 1.915 1.706 -0.705
ENSG00000160199 E010 88.4292277 0.0004945867 2.632982e-06 1.995881e-05 21 43007491 43007618 128 + 2.017 1.834 -0.618
ENSG00000160199 E011 0.1451727 0.0437033433 8.244803e-01   21 43007619 43007712 94 + 0.098 0.000 -9.929
ENSG00000160199 E012 102.7138115 0.0005477518 6.358038e-07 5.509108e-06 21 43010053 43010224 172 + 2.082 1.900 -0.610
ENSG00000160199 E013 112.9911708 0.0067021773 1.247873e-01 2.268291e-01 21 43013068 43013238 171 + 2.088 2.006 -0.274
ENSG00000160199 E014 71.9293265 0.0003504080 1.948570e-01 3.198225e-01 21 43016908 43017007 100 + 1.884 1.831 -0.180
ENSG00000160199 E015 1.1102619 0.0120551965 3.044967e-01 4.465032e-01 21 43017008 43018051 1044 + 0.245 0.428 1.150
ENSG00000160199 E016 0.0000000       21 43018131 43018132 2 +      
ENSG00000160199 E017 73.1402333 0.0004129598 2.701468e-01 4.087345e-01 21 43018133 43018230 98 + 1.887 1.842 -0.154
ENSG00000160199 E018 0.8908930 0.0828138137 6.157390e-01 7.339381e-01 21 43020451 43020548 98 + 0.245 0.351 0.716
ENSG00000160199 E019 1.2125587 0.0162914404 2.976629e-01 4.390106e-01 21 43021151 43021302 152 + 0.245 0.429 1.154
ENSG00000160199 E020 88.7178594 0.0003639589 2.348388e-02 5.874521e-02 21 43021303 43021431 129 + 1.986 1.900 -0.287
ENSG00000160199 E021 0.2924217 0.0290785164 3.943660e-01   21 43024435 43024734 300 + 0.177 0.000 -11.073
ENSG00000160199 E022 0.3030308 0.3832233302 5.064914e-01   21 43024817 43024870 54 + 0.178 0.000 -10.150
ENSG00000160199 E023 74.2582798 0.0003616699 1.568677e-01 2.709260e-01 21 43024871 43024947 77 + 1.901 1.844 -0.193
ENSG00000160199 E024 0.0000000       21 43028615 43028701 87 +      
ENSG00000160199 E025 97.6527695 0.0009682608 7.416844e-01 8.307460e-01 21 43028702 43028874 173 + 1.990 2.003 0.042
ENSG00000160199 E026 0.2924217 0.0290785164 3.943660e-01   21 43028875 43028875 1 + 0.177 0.000 -11.073
ENSG00000160199 E027 535.2747160 0.0001995316 9.507147e-38 2.854359e-35 21 43029890 43033931 4042 + 2.654 2.816 0.536