ENSG00000160194

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460740 ENSG00000160194 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFV3 protein_coding processed_transcript 97.12992 150.8482 74.64228 5.85115 1.814106 -1.014935 13.343339 18.319585 12.085462 1.1573468 0.3921082 -0.5997083 0.14135833 0.1212333 0.16213333 0.040900000 6.488559e-03 9.731364e-46 FALSE  
MSTRG.21397.14 ENSG00000160194 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFV3 protein_coding   97.12992 150.8482 74.64228 5.85115 1.814106 -1.014935 2.625137 10.984802 0.000000 0.5791325 0.0000000 -10.1026059 0.01839167 0.0732000 0.00000000 -0.073200000 9.731364e-46 9.731364e-46 TRUE  
MSTRG.21397.5 ENSG00000160194 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFV3 protein_coding   97.12992 150.8482 74.64228 5.85115 1.814106 -1.014935 6.024375 8.121839 3.796781 0.6625461 1.3326474 -1.0950101 0.06119583 0.0543000 0.05093333 -0.003366667 8.814481e-01 9.731364e-46 TRUE  
MSTRG.21397.6 ENSG00000160194 HEK293_OSMI2_2hA HEK293_TMG_2hB NDUFV3 protein_coding   97.12992 150.8482 74.64228 5.85115 1.814106 -1.014935 57.507273 88.954998 41.052916 6.2177542 1.6177993 -1.1154018 0.59042917 0.5884333 0.54960000 -0.038833333 5.478839e-01 9.731364e-46 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160194 E001 8.584552 2.264136e-01 1.118276e-01 2.082471e-01 21 42879596 42879623 28 + 1.137 0.827 -1.155
ENSG00000160194 E002 13.215469 2.662637e-02 2.811912e-02 6.824957e-02 21 42879624 42879643 20 + 1.274 1.021 -0.906
ENSG00000160194 E003 19.239709 2.458309e-02 4.909385e-02 1.075410e-01 21 42879644 42879653 10 + 1.396 1.196 -0.700
ENSG00000160194 E004 74.361439 1.485119e-02 7.234058e-02 1.472389e-01 21 42879654 42879721 68 + 1.911 1.788 -0.415
ENSG00000160194 E005 50.588545 2.527002e-02 1.923529e-01 3.167158e-01 21 42879722 42879755 34 + 1.736 1.630 -0.360
ENSG00000160194 E006 31.655933 7.759303e-03 4.256641e-02 9.575812e-02 21 42879756 42879865 110 + 1.570 1.418 -0.520
ENSG00000160194 E007 115.194869 1.752734e-02 2.194165e-01 3.496825e-01 21 42883606 42883795 190 + 2.066 1.987 -0.266
ENSG00000160194 E008 1.325377 9.936886e-03 6.133325e-01 7.320313e-01 21 42884802 42884910 109 + 0.402 0.310 -0.552
ENSG00000160194 E009 1.583458 1.551488e-02 4.785985e-02 1.053740e-01 21 42886801 42886959 159 + 0.608 0.263 -1.874
ENSG00000160194 E010 1.544746 8.851233e-03 7.859777e-01 8.629448e-01 21 42893216 42893231 16 + 0.402 0.352 -0.288
ENSG00000160194 E011 2.317634 7.035434e-03 6.264071e-01 7.423615e-01 21 42893232 42893243 12 + 0.402 0.489 0.450
ENSG00000160194 E012 2.760525 4.112620e-02 4.396598e-01 5.814101e-01 21 42893244 42893251 8 + 0.402 0.547 0.727
ENSG00000160194 E013 12.409722 5.397790e-02 8.781140e-02 1.718022e-01 21 42893252 42893267 16 + 0.851 1.119 0.993
ENSG00000160194 E014 111.409152 1.942507e-03 1.081589e-01 2.028148e-01 21 42893268 42893308 41 + 1.937 2.004 0.226
ENSG00000160194 E015 220.064983 4.642635e-03 5.257931e-01 6.591141e-01 21 42893309 42893320 12 + 2.264 2.288 0.079
ENSG00000160194 E016 975.033595 1.569673e-03 5.427432e-03 1.709070e-02 21 42893321 42893381 61 + 2.887 2.941 0.179
ENSG00000160194 E017 1519.346200 9.052572e-05 7.873219e-07 6.688000e-06 21 42896927 42897047 121 + 3.087 3.133 0.153
ENSG00000160194 E018 3.208733 4.734779e-03 2.003658e-04 9.653299e-04 21 42898302 42898390 89 + 0.910 0.352 -2.510
ENSG00000160194 E019 863.843168 1.047610e-03 4.464905e-15 1.547782e-13 21 42903182 42904276 1095 + 2.980 2.836 -0.479
ENSG00000160194 E020 1689.557729 4.311335e-04 6.800468e-09 8.651724e-08 21 42908864 42910483 1620 + 3.120 3.184 0.212
ENSG00000160194 E021 21.976369 1.536689e-03 1.399739e-07 1.383000e-06 21 42910484 42910521 38 + 1.557 1.162 -1.375
ENSG00000160194 E022 24.138712 8.752158e-04 7.519494e-14 2.176540e-12 21 42910522 42910559 38 + 1.665 1.143 -1.811
ENSG00000160194 E023 7.976341 3.546626e-02 3.404493e-02 7.984586e-02 21 42910560 42910597 38 + 1.104 0.816 -1.077
ENSG00000160194 E024 4.147697 6.472739e-03 2.846541e-02 6.894397e-02 21 42910598 42910635 38 + 0.882 0.568 -1.291
ENSG00000160194 E025 11.800702 1.376497e-02 2.478034e-06 1.889540e-05 21 42910636 42910673 38 + 1.369 0.859 -1.846
ENSG00000160194 E026 18.395411 4.629869e-03 7.756983e-07 6.599026e-06 21 42910674 42910711 38 + 1.499 1.080 -1.468
ENSG00000160194 E027 170.704341 1.067705e-03 5.618026e-02 1.200165e-01 21 42910712 42912527 1816 + 2.221 2.156 -0.217
ENSG00000160194 E028 13.408701 7.995364e-03 2.067486e-02 5.290242e-02 21 42912528 42912661 134 + 1.262 1.025 -0.850
ENSG00000160194 E029 20.502164 1.826246e-02 8.043333e-02 1.602399e-01 21 42912662 42913304 643 + 1.405 1.228 -0.618