ENSG00000160191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291539 ENSG00000160191 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE9A protein_coding protein_coding 10.64607 13.48973 10.66786 0.5694916 0.7426721 -0.3383074 0.9149487 0.6323532 1.066115 0.2055713 0.08207931 0.74439336 0.08827083 0.04653333 0.1010333 0.0545000 0.089905622 0.002497158 FALSE TRUE
ENST00000335512 ENSG00000160191 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE9A protein_coding protein_coding 10.64607 13.48973 10.66786 0.5694916 0.7426721 -0.3383074 5.5910538 6.0705004 5.784054 1.0346795 0.24385345 -0.06961682 0.53843750 0.44493333 0.5442333 0.0993000 0.474288520 0.002497158 FALSE TRUE
ENST00000486902 ENSG00000160191 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE9A protein_coding processed_transcript 10.64607 13.48973 10.66786 0.5694916 0.7426721 -0.3383074 2.0749208 3.2891668 1.460364 0.0278372 0.22371225 -1.16592820 0.18831667 0.24493333 0.1356000 -0.1093333 0.002497158 0.002497158 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160191 E001 0.0000000       21 42653621 42653635 15 +      
ENSG00000160191 E002 1.5812911 0.2598686320 3.243826e-01 4.677310e-01 21 42653636 42653748 113 + 0.241 0.481 1.444
ENSG00000160191 E003 1.5812911 0.2598686320 3.243826e-01 4.677310e-01 21 42653749 42653749 1 + 0.241 0.481 1.444
ENSG00000160191 E004 2.1702872 0.2006747025 9.065422e-01 9.446151e-01 21 42653750 42653754 5 + 0.509 0.480 -0.140
ENSG00000160191 E005 4.4951961 0.0037409542 5.150621e-01 6.497724e-01 21 42653755 42653778 24 + 0.673 0.768 0.391
ENSG00000160191 E006 20.7048108 0.0008897439 8.684110e-01 9.194075e-01 21 42653779 42653812 34 + 1.322 1.340 0.060
ENSG00000160191 E007 41.1424958 0.0005679885 8.631287e-01 9.157489e-01 21 42653813 42653883 71 + 1.621 1.616 -0.016
ENSG00000160191 E008 23.8215740 0.0011079908 9.510394e-01 9.733733e-01 21 42686192 42686196 5 + 1.380 1.388 0.029
ENSG00000160191 E009 52.4842643 0.0023725438 8.956834e-01 9.373541e-01 21 42686197 42686262 66 + 1.714 1.724 0.034
ENSG00000160191 E010 72.8294026 0.0003848025 7.348034e-01 8.256748e-01 21 42687917 42687994 78 + 1.851 1.870 0.063
ENSG00000160191 E011 6.1118760 0.0028362583 4.328844e-01 5.753378e-01 21 42697415 42697490 76 + 0.791 0.895 0.402
ENSG00000160191 E012 0.7760110 0.0160749120 4.583323e-01 5.986726e-01 21 42698913 42698967 55 + 0.325 0.196 -0.960
ENSG00000160191 E013 63.6025224 0.0004259040 1.329473e-01 2.382104e-01 21 42698968 42699011 44 + 1.840 1.779 -0.205
ENSG00000160191 E014 0.6664265 0.0177731310 7.894006e-01 8.652034e-01 21 42699012 42699038 27 + 0.241 0.196 -0.374
ENSG00000160191 E015 38.0630549 0.0012574561 7.880541e-07 6.692419e-06 21 42700694 42701189 496 + 1.366 1.678 1.068
ENSG00000160191 E016 0.0000000       21 42724556 42724634 79 +      
ENSG00000160191 E017 0.0000000       21 42731758 42731769 12 +      
ENSG00000160191 E018 15.6184616 0.0058355639 4.715238e-03 1.513816e-02 21 42731770 42731949 180 + 1.352 1.103 -0.878
ENSG00000160191 E019 35.6516952 0.0006380098 4.323645e-01 5.748196e-01 21 42732070 42732124 55 + 1.585 1.544 -0.138
ENSG00000160191 E020 40.4826971 0.0005914729 2.333397e-01 3.663763e-01 21 42733356 42733426 71 + 1.650 1.591 -0.203
ENSG00000160191 E021 52.7848851 0.0004875359 6.534681e-01 7.639333e-01 21 42743776 42743860 85 + 1.738 1.722 -0.055
ENSG00000160191 E022 54.3224081 0.0005362352 2.704082e-01 4.090552e-01 21 42751116 42751197 82 + 1.767 1.719 -0.159
ENSG00000160191 E023 60.1494233 0.0043888935 5.846142e-01 7.084908e-01 21 42753990 42754064 75 + 1.796 1.767 -0.096
ENSG00000160191 E024 10.7111515 0.1120703239 1.930540e-01 3.176023e-01 21 42756775 42758998 2224 + 0.907 1.125 0.805
ENSG00000160191 E025 65.1029940 0.0085025173 8.013051e-01 8.733961e-01 21 42758999 42759085 87 + 1.804 1.814 0.036
ENSG00000160191 E026 65.0229639 0.0069496983 5.692698e-01 6.958578e-01 21 42760328 42760432 105 + 1.831 1.794 -0.123
ENSG00000160191 E027 63.8858702 0.0021201759 3.630842e-02 8.416872e-02 21 42760825 42760907 83 + 1.860 1.764 -0.325
ENSG00000160191 E028 82.3074611 0.0003931164 4.959581e-03 1.581861e-02 21 42762083 42762213 131 + 1.976 1.875 -0.342
ENSG00000160191 E029 49.2031750 0.0004598152 5.005438e-02 1.092673e-01 21 42762214 42762239 26 + 1.750 1.659 -0.309
ENSG00000160191 E030 74.9908001 0.0003756843 5.351074e-01 6.670472e-01 21 42765381 42765494 114 + 1.888 1.868 -0.067
ENSG00000160191 E031 64.5619782 0.0004956123 3.875383e-02 8.872832e-02 21 42768188 42768292 105 + 1.753 1.849 0.326
ENSG00000160191 E032 0.0000000       21 42768293 42768412 120 +      
ENSG00000160191 E033 97.7932836 0.0116213456 2.825291e-01 4.225324e-01 21 42769027 42769155 129 + 1.943 2.014 0.238
ENSG00000160191 E034 91.6940786 0.0067261112 6.928739e-01 7.939758e-01 21 42770703 42770798 96 + 1.945 1.969 0.079
ENSG00000160191 E035 84.2090518 0.0031088756 1.092081e-01 2.043776e-01 21 42772439 42772520 82 + 1.874 1.950 0.256
ENSG00000160191 E036 58.7318971 0.0004746715 9.373263e-03 2.721602e-02 21 42775280 42775509 230 + 1.688 1.815 0.428