ENSG00000160124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291458 ENSG00000160124 HEK293_OSMI2_2hA HEK293_TMG_2hB MIX23 protein_coding protein_coding 61.41141 54.9058 92.09618 7.039262 3.277977 0.7460767 40.925939 40.087786 58.92402 5.303334 0.6254664 0.555578 0.6708500 0.7295000 0.6409000 -0.08860000 0.01134799 0.01134799 FALSE  
ENST00000479414 ENSG00000160124 HEK293_OSMI2_2hA HEK293_TMG_2hB MIX23 protein_coding protein_coding 61.41141 54.9058 92.09618 7.039262 3.277977 0.7460767 9.397760 6.465384 13.67879 1.912299 0.8071108 1.079957 0.1482458 0.1137667 0.1483000 0.03453333 0.55002400 0.01134799 FALSE  
ENST00000479899 ENSG00000160124 HEK293_OSMI2_2hA HEK293_TMG_2hB MIX23 protein_coding protein_coding 61.41141 54.9058 92.09618 7.039262 3.277977 0.7460767 7.575102 5.403538 12.98676 1.776469 1.0428089 1.263508 0.1172542 0.1056667 0.1405667 0.03490000 0.61638433 0.01134799 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160124 E001 1.693883 0.0778968556 3.110012e-02 7.410074e-02 3 122359591 122359599 9 - 0.197 0.627 2.495
ENSG00000160124 E002 5.591463 0.0363968016 1.183873e-03 4.586526e-03 3 122359600 122359628 29 - 0.518 1.032 2.088
ENSG00000160124 E003 6.517855 0.0492650964 1.157677e-03 4.497458e-03 3 122359629 122359636 8 - 0.554 1.095 2.147
ENSG00000160124 E004 10.678608 0.0397224737 2.787104e-06 2.101443e-05 3 122359637 122359645 9 - 0.619 1.314 2.637
ENSG00000160124 E005 136.445637 0.0077245603 1.718770e-09 2.438157e-08 3 122359646 122359787 142 - 1.964 2.278 1.052
ENSG00000160124 E006 150.963237 0.0042590960 9.785095e-11 1.728928e-09 3 122359788 122359827 40 - 2.036 2.307 0.908
ENSG00000160124 E007 118.076572 0.0003951756 6.974807e-25 7.567905e-23 3 122359828 122359861 34 - 1.885 2.229 1.151
ENSG00000160124 E008 230.076954 0.0002985250 1.574495e-08 1.870466e-07 3 122359862 122359919 58 - 2.302 2.435 0.444
ENSG00000160124 E009 335.255754 0.0001495057 1.049343e-01 1.979950e-01 3 122362968 122363027 60 - 2.517 2.548 0.103
ENSG00000160124 E010 13.706124 0.0015650840 5.578463e-04 2.376967e-03 3 122365336 122365466 131 - 1.300 0.977 -1.159
ENSG00000160124 E011 6.265376 0.0076470060 2.489263e-03 8.731893e-03 3 122365467 122365564 98 - 1.008 0.597 -1.637
ENSG00000160124 E012 10.989253 0.0408830214 2.182419e-04 1.042047e-03 3 122365565 122365633 69 - 1.262 0.706 -2.081
ENSG00000160124 E013 9.406797 0.0018258684 2.675042e-05 1.610304e-04 3 122366453 122366762 310 - 1.186 0.704 -1.822
ENSG00000160124 E014 4.659201 0.0421521197 5.905721e-02 1.250189e-01 3 122367824 122368175 352 - 0.880 0.555 -1.347
ENSG00000160124 E015 564.771213 0.0002118250 2.599155e-02 6.393172e-02 3 122368176 122368322 147 - 2.772 2.739 -0.107
ENSG00000160124 E016 404.262564 0.0002449715 6.036007e-14 1.769581e-12 3 122371675 122371730 56 - 2.670 2.538 -0.442
ENSG00000160124 E017 385.794797 0.0030761997 2.231905e-04 1.062808e-03 3 122371731 122371800 70 - 2.641 2.524 -0.389
ENSG00000160124 E018 6.109413 0.0034442704 9.130058e-01 9.488935e-01 3 122372983 122373022 40 - 0.847 0.862 0.057
ENSG00000160124 E019 24.391448 0.0493135188 1.552374e-01 2.687126e-01 3 122383148 122383173 26 - 1.481 1.291 -0.656
ENSG00000160124 E020 258.940058 0.0019914786 7.887052e-09 9.909658e-08 3 122383174 122383231 58 - 2.491 2.319 -0.575