ENSG00000160058

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341071 ENSG00000160058 HEK293_OSMI2_2hA HEK293_TMG_2hB BSDC1 protein_coding protein_coding 42.39126 46.48344 28.96646 0.9558656 1.010052 -0.6821458 9.611791 5.800696 8.274944 0.2785623 0.4962434 0.5117810 0.2302458 0.1247333 0.28523333 0.1605000 3.107317e-16 3.107317e-16 FALSE TRUE
ENST00000444377 ENSG00000160058 HEK293_OSMI2_2hA HEK293_TMG_2hB BSDC1 protein_coding nonsense_mediated_decay 42.39126 46.48344 28.96646 0.9558656 1.010052 -0.6821458 4.342331 7.377518 1.835704 1.6056659 0.5313428 -2.0009187 0.1025500 0.1579333 0.06253333 -0.0954000 9.302669e-02 3.107317e-16 TRUE TRUE
ENST00000455895 ENSG00000160058 HEK293_OSMI2_2hA HEK293_TMG_2hB BSDC1 protein_coding protein_coding 42.39126 46.48344 28.96646 0.9558656 1.010052 -0.6821458 24.918246 30.087303 15.889825 1.5565604 0.5210557 -0.9206233 0.5804375 0.6489667 0.54870000 -0.1002667 2.697713e-01 3.107317e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160058 E001 110.470715 0.0112996425 7.589853e-04 3.111475e-03 1 32364633 32365112 480 - 2.140 1.939 -0.673
ENSG00000160058 E002 53.296710 0.0004824001 4.077950e-01 5.513960e-01 1 32365113 32365170 58 - 1.670 1.720 0.170
ENSG00000160058 E003 1203.094986 0.0013731059 3.286087e-07 3.015302e-06 1 32365171 32366071 901 - 2.974 3.080 0.351
ENSG00000160058 E004 368.562698 0.0009794829 2.950665e-05 1.759062e-04 1 32366072 32366193 122 - 2.458 2.569 0.369
ENSG00000160058 E005 371.324960 0.0007406538 1.736250e-01 2.929006e-01 1 32366194 32366295 102 - 2.512 2.551 0.131
ENSG00000160058 E006 198.011806 0.0006934611 2.922034e-01 4.331478e-01 1 32366296 32366300 5 - 2.283 2.260 -0.076
ENSG00000160058 E007 511.409533 0.0001426555 1.271794e-01 2.302019e-01 1 32366301 32366476 176 - 2.656 2.689 0.112
ENSG00000160058 E008 500.397234 0.0001148478 3.828255e-04 1.708243e-03 1 32366477 32366654 178 - 2.621 2.689 0.228
ENSG00000160058 E009 291.899096 0.0004504491 1.143496e-64 1.337234e-61 1 32366655 32368024 1370 - 2.653 2.277 -1.252
ENSG00000160058 E010 13.726927 0.0018111731 3.788817e-04 1.692917e-03 1 32368025 32368032 8 - 1.332 1.020 -1.113
ENSG00000160058 E011 76.379235 0.0003389494 4.192872e-24 4.196128e-22 1 32368033 32368446 414 - 2.089 1.687 -1.353
ENSG00000160058 E012 381.409439 0.0012999229 2.816045e-02 6.832996e-02 1 32368447 32368550 104 - 2.505 2.569 0.214
ENSG00000160058 E013 9.267461 0.0084198832 4.039220e-01 5.476837e-01 1 32369230 32369338 109 - 1.042 0.955 -0.324
ENSG00000160058 E014 1.856199 0.0314702032 8.391695e-03 2.476874e-02 1 32374693 32374782 90 - 0.693 0.238 -2.431
ENSG00000160058 E015 436.609164 0.0005991500 5.546555e-01 6.836064e-01 1 32376262 32376447 186 - 2.595 2.615 0.067
ENSG00000160058 E016 427.168930 0.0001458995 1.270564e-01 2.300376e-01 1 32376448 32376629 182 - 2.576 2.611 0.119
ENSG00000160058 E017 240.877400 0.0031560467 2.827923e-01 4.228358e-01 1 32376630 32376686 57 - 2.320 2.366 0.155
ENSG00000160058 E018 213.514467 0.0038230524 3.973000e-01 5.410593e-01 1 32376687 32376741 55 - 2.271 2.312 0.136
ENSG00000160058 E019 243.390904 0.0053779485 4.251240e-01 5.680684e-01 1 32377970 32378048 79 - 2.329 2.368 0.131
ENSG00000160058 E020 143.024686 0.0092079201 5.886764e-01 7.118610e-01 1 32378215 32378226 12 - 2.105 2.136 0.104
ENSG00000160058 E021 214.394954 0.0052430926 7.647887e-01 8.477630e-01 1 32378227 32378283 57 - 2.308 2.299 -0.031
ENSG00000160058 E022 212.318716 0.0037582310 4.360183e-01 5.781564e-01 1 32378724 32378762 39 - 2.314 2.288 -0.087
ENSG00000160058 E023 286.087110 0.0024842580 3.824576e-02 8.781201e-02 1 32378763 32378839 77 - 2.467 2.406 -0.204
ENSG00000160058 E024 240.260547 0.0021898326 1.641092e-02 4.363754e-02 1 32381214 32381268 55 - 2.398 2.327 -0.236
ENSG00000160058 E025 262.689672 0.0001687271 1.554698e-01 2.690216e-01 1 32383830 32383896 67 - 2.407 2.381 -0.085
ENSG00000160058 E026 169.344083 0.0002176274 5.973122e-01 7.190954e-01 1 32383897 32383906 10 - 2.207 2.199 -0.026
ENSG00000160058 E027 209.760673 0.0001865946 7.763304e-01 8.559745e-01 1 32383907 32383939 33 - 2.293 2.293 0.000
ENSG00000160058 E028 135.164282 0.0003417154 1.303771e-01 2.346861e-01 1 32383940 32383940 1 - 2.133 2.091 -0.138
ENSG00000160058 E029 229.436716 0.0002199445 2.962812e-01 4.374836e-01 1 32383941 32383997 57 - 2.345 2.326 -0.062
ENSG00000160058 E030 23.848535 0.0030366018 7.423164e-01 8.312376e-01 1 32383998 32384048 51 - 1.374 1.355 -0.066
ENSG00000160058 E031 1.109317 0.1261933639 9.302251e-01 9.601153e-01 1 32386421 32386778 358 - 0.272 0.299 0.182
ENSG00000160058 E032 291.725913 0.0002109745 9.167491e-01 9.514008e-01 1 32386779 32386895 117 - 2.428 2.438 0.033
ENSG00000160058 E033 0.000000       1 32393601 32394079 479 -      
ENSG00000160058 E034 184.179047 0.0002105782 1.065503e-02 3.034520e-02 1 32394080 32394140 61 - 2.179 2.259 0.268
ENSG00000160058 E035 10.392439 0.0017561617 3.200477e-03 1.085721e-02 1 32394141 32394403 263 - 1.199 0.906 -1.072
ENSG00000160058 E036 85.150516 0.0003692841 5.769030e-02 1.226669e-01 1 32394404 32394731 328 - 1.948 1.879 -0.232