ENSG00000160055

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309777 ENSG00000160055 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM234 protein_coding protein_coding 23.31873 34.82501 11.72622 0.625256 0.4268688 -1.56957 14.364096 24.3050268 6.3140755 1.3401562 0.22206749 -1.9429217 0.59342500 0.69706667 0.53850000 -0.15856667 0.002281933 0.002281933 FALSE TRUE
ENST00000373593 ENSG00000160055 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM234 protein_coding protein_coding 23.31873 34.82501 11.72622 0.625256 0.4268688 -1.56957 1.459668 1.6260039 0.4105369 0.2456090 0.07088677 -1.9598719 0.06197917 0.04683333 0.03470000 -0.01213333 0.643139372 0.002281933 FALSE TRUE
ENST00000466796 ENSG00000160055 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM234 protein_coding retained_intron 23.31873 34.82501 11.72622 0.625256 0.4268688 -1.56957 1.480123 1.7610155 0.7286676 0.1248604 0.03590089 -1.2615796 0.06459583 0.05056667 0.06250000 0.01193333 0.612592725 0.002281933 TRUE FALSE
ENST00000484490 ENSG00000160055 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM234 protein_coding nonsense_mediated_decay 23.31873 34.82501 11.72622 0.625256 0.4268688 -1.56957 1.057732 0.7110935 0.6478613 0.4619462 0.16204517 -0.1324029 0.05284167 0.02076667 0.05643333 0.03566667 0.457584849 0.002281933   FALSE
ENST00000487174 ENSG00000160055 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM234 protein_coding retained_intron 23.31873 34.82501 11.72622 0.625256 0.4268688 -1.56957 2.266403 3.3810126 1.3283118 0.3954147 0.23986571 -1.3413019 0.09881250 0.09750000 0.11223333 0.01473333 0.821845812 0.002281933   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160055 E001 0.5869318 0.3474087694 3.153767e-01 4.581417e-01 1 32209243 32209255 13 - 0.343 0.127 -1.829
ENSG00000160055 E002 0.8010032 0.1572554318 1.096796e-01 2.050918e-01 1 32209256 32209294 39 - 0.449 0.131 -2.363
ENSG00000160055 E003 0.8041237 0.0163624651 3.873374e-01 5.314804e-01 1 32209295 32209329 35 - 0.344 0.183 -1.201
ENSG00000160055 E004 2.9347456 0.0093612861 3.155990e-03 1.072530e-02 1 32209330 32209387 58 - 0.848 0.381 -2.106
ENSG00000160055 E005 2.2948046 0.3303070610 3.998649e-01 5.435871e-01 1 32210193 32210323 131 - 0.206 0.479 1.735
ENSG00000160055 E006 2.1629098 0.0077962384 1.945206e-01 3.194049e-01 1 32214472 32214476 5 - 0.205 0.467 1.675
ENSG00000160055 E007 2.3112029 0.0065334904 1.551248e-01 2.685620e-01 1 32214477 32214477 1 - 0.205 0.492 1.800
ENSG00000160055 E008 23.1799692 0.0008528992 6.549094e-01 7.649426e-01 1 32214478 32214664 187 - 1.253 1.292 0.135
ENSG00000160055 E009 25.6024114 0.0077409187 1.122721e-01 2.088594e-01 1 32214665 32214732 68 - 1.431 1.296 -0.470
ENSG00000160055 E010 33.8024880 0.0006545858 1.919426e-03 6.975919e-03 1 32214733 32214860 128 - 1.598 1.392 -0.709
ENSG00000160055 E011 40.9355724 0.0005461905 6.871950e-07 5.910607e-06 1 32214861 32215049 189 - 1.743 1.452 -0.993
ENSG00000160055 E012 20.7590549 0.0009218891 1.168961e-03 4.535806e-03 1 32215136 32215216 81 - 1.441 1.177 -0.923
ENSG00000160055 E013 26.4827838 0.0007718523 3.624966e-02 8.406030e-02 1 32215217 32215548 332 - 1.459 1.300 -0.554
ENSG00000160055 E014 9.5400548 0.0336982645 9.885925e-01 9.969280e-01 1 32215549 32215672 124 - 0.917 0.920 0.011
ENSG00000160055 E015 29.2098115 0.0188267499 1.470440e-02 3.982387e-02 1 32215673 32215795 123 - 1.549 1.319 -0.796
ENSG00000160055 E016 9.7854229 0.0642216129 5.209092e-01 6.548506e-01 1 32215796 32215846 51 - 1.003 0.909 -0.352
ENSG00000160055 E017 18.8771951 0.0047890980 1.918037e-02 4.973126e-02 1 32215847 32216193 347 - 1.357 1.141 -0.760
ENSG00000160055 E018 8.9488647 0.0019921509 2.359864e-03 8.337732e-03 1 32216194 32216196 3 - 1.155 0.809 -1.290
ENSG00000160055 E019 10.6815564 0.0016731344 1.308351e-02 3.610332e-02 1 32216197 32216199 3 - 1.173 0.904 -0.987
ENSG00000160055 E020 65.9627496 0.0014036356 4.836325e-02 1.062687e-01 1 32216200 32216281 82 - 1.636 1.749 0.382
ENSG00000160055 E021 65.2415443 0.0018998657 1.306364e-06 1.058269e-05 1 32216282 32216319 38 - 1.459 1.770 1.058
ENSG00000160055 E022 65.0242676 0.0006292062 2.675330e-04 1.247405e-03 1 32216320 32216356 37 - 1.542 1.755 0.724
ENSG00000160055 E023 89.1665136 0.0003405584 3.700051e-02 8.547607e-02 1 32216357 32216383 27 - 1.775 1.873 0.328
ENSG00000160055 E024 196.5498414 0.0002079434 2.473612e-04 1.164298e-03 1 32216384 32216517 134 - 2.096 2.212 0.385
ENSG00000160055 E025 152.8769694 0.0002963919 1.576063e-04 7.809902e-04 1 32216518 32216588 71 - 1.968 2.106 0.463
ENSG00000160055 E026 189.5270636 0.0021677683 5.137468e-03 1.630227e-02 1 32216589 32216729 141 - 2.088 2.194 0.355
ENSG00000160055 E027 192.2057270 0.0002083364 2.294148e-02 5.762349e-02 1 32216730 32216888 159 - 2.127 2.197 0.235
ENSG00000160055 E028 137.2810345 0.0002548642 3.693963e-01 5.138220e-01 1 32216889 32216941 53 - 2.013 2.046 0.108
ENSG00000160055 E029 96.4641967 0.0002880495 2.660471e-02 6.516855e-02 1 32216942 32216947 6 - 1.959 1.867 -0.311
ENSG00000160055 E030 34.1535680 0.0006371365 7.377304e-01 8.278198e-01 1 32216948 32217258 311 - 1.468 1.444 -0.083
ENSG00000160055 E031 175.3693481 0.0002745084 1.664755e-03 6.169220e-03 1 32217259 32217351 93 - 2.222 2.125 -0.322
ENSG00000160055 E032 0.7675920 0.0157664657 7.527852e-02 1.519778e-01 1 32217352 32217427 76 - 0.449 0.130 -2.371
ENSG00000160055 E033 10.5922188 0.0446472285 3.943715e-01 5.382202e-01 1 32217437 32217577 141 - 1.075 0.947 -0.471
ENSG00000160055 E034 131.4415663 0.0003479719 3.397870e-03 1.143226e-02 1 32221131 32221197 67 - 2.103 1.999 -0.349
ENSG00000160055 E035 108.7918332 0.0003351147 1.070375e-01 2.011619e-01 1 32221867 32222018 152 - 1.990 1.926 -0.216
ENSG00000160055 E036 38.6206772 0.0077986331 3.197701e-01 4.628558e-01 1 32222019 32222306 288 - 1.564 1.486 -0.265
ENSG00000160055 E037 40.9511148 0.0095786292 6.050743e-01 7.254941e-01 1 32222307 32222359 53 - 1.549 1.508 -0.142