ENSG00000160049

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377036 ENSG00000160049 HEK293_OSMI2_2hA HEK293_TMG_2hB DFFA protein_coding protein_coding 102.8725 147.6437 95.38252 4.943781 1.001842 -0.6302697 32.321233 54.303821 26.318783 4.5361621 1.2059199 -1.0446785 0.3091333 0.36763333 0.27620000 -0.09143333 1.120773e-01 2.911387e-07 FALSE TRUE
ENST00000377038 ENSG00000160049 HEK293_OSMI2_2hA HEK293_TMG_2hB DFFA protein_coding protein_coding 102.8725 147.6437 95.38252 4.943781 1.001842 -0.6302697 25.809875 23.145381 31.271399 2.0614031 0.7491021 0.4339575 0.2680208 0.15726667 0.32810000 0.17083333 2.911387e-07 2.911387e-07 FALSE TRUE
ENST00000476658 ENSG00000160049 HEK293_OSMI2_2hA HEK293_TMG_2hB DFFA protein_coding nonsense_mediated_decay 102.8725 147.6437 95.38252 4.943781 1.001842 -0.6302697 10.322970 14.556679 12.157642 0.4215124 0.5092951 -0.2596223 0.0982250 0.09896667 0.12760000 0.02863333 1.364541e-01 2.911387e-07 TRUE TRUE
MSTRG.286.1 ENSG00000160049 HEK293_OSMI2_2hA HEK293_TMG_2hB DFFA protein_coding   102.8725 147.6437 95.38252 4.943781 1.001842 -0.6302697 24.296939 41.185210 17.311156 6.3084799 3.6352105 -1.2499414 0.2282375 0.27773333 0.18073333 -0.09700000 3.297445e-01 2.911387e-07 FALSE TRUE
MSTRG.286.3 ENSG00000160049 HEK293_OSMI2_2hA HEK293_TMG_2hB DFFA protein_coding   102.8725 147.6437 95.38252 4.943781 1.001842 -0.6302697 5.167525 4.551806 6.263899 1.1829491 0.3959905 0.4597572 0.0537125 0.03096667 0.06563333 0.03466667 4.602169e-02 2.911387e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000160049 E001 3.286052 0.0090009988 2.984244e-02 7.165567e-02 1 10451561 10451585 25 - 0.803 0.468 -1.470
ENSG00000160049 E002 641.587337 0.0111606349 2.431728e-01 3.779068e-01 1 10456522 10457019 498 - 2.832 2.771 -0.203
ENSG00000160049 E003 1223.131631 0.0084196837 1.861854e-05 1.163545e-04 1 10457020 10458121 1102 - 3.181 2.995 -0.616
ENSG00000160049 E004 572.081109 0.0028165268 6.372207e-14 1.861520e-12 1 10458122 10458620 499 - 2.873 2.647 -0.753
ENSG00000160049 E005 140.498872 0.0037884077 2.501259e-10 4.118338e-09 1 10458621 10458767 147 - 2.290 2.017 -0.913
ENSG00000160049 E006 202.241096 0.0002331440 4.056689e-28 5.782751e-26 1 10458768 10458934 167 - 2.454 2.168 -0.957
ENSG00000160049 E007 931.340502 0.0003843579 6.704292e-54 5.248380e-51 1 10458935 10460251 1317 - 3.086 2.855 -0.767
ENSG00000160049 E008 261.132713 0.0001791270 1.027550e-45 4.965976e-43 1 10460252 10460643 392 - 2.579 2.254 -1.086
ENSG00000160049 E009 196.404402 0.0002491743 1.016164e-39 3.437664e-37 1 10460644 10461022 379 - 2.468 2.119 -1.167
ENSG00000160049 E010 133.803309 0.0031625243 3.246873e-11 6.216375e-10 1 10461023 10461142 120 - 2.271 1.990 -0.943
ENSG00000160049 E011 764.976322 0.0005297676 4.698755e-11 8.764055e-10 1 10461143 10461642 500 - 2.941 2.822 -0.396
ENSG00000160049 E012 318.163907 0.0023773034 4.905059e-02 1.074673e-01 1 10461643 10461702 60 - 2.534 2.460 -0.246
ENSG00000160049 E013 110.990638 0.0008141032 3.603624e-01 5.046763e-01 1 10462468 10462587 120 - 2.025 2.050 0.084
ENSG00000160049 E014 299.648410 0.0022765540 1.142959e-04 5.875827e-04 1 10462588 10462795 208 - 2.394 2.505 0.370
ENSG00000160049 E015 249.997831 0.0002203387 4.654080e-13 1.204510e-11 1 10462796 10462898 103 - 2.278 2.445 0.557
ENSG00000160049 E016 340.474967 0.0006936136 1.222247e-29 1.994410e-27 1 10462899 10462987 89 - 2.340 2.606 0.885
ENSG00000160049 E017 417.507726 0.0002520629 1.005081e-60 1.046207e-57 1 10462988 10463057 70 - 2.382 2.707 1.085
ENSG00000160049 E018 1065.418352 0.0001475300 3.374770e-43 1.411347e-40 1 10463058 10463209 152 - 2.909 3.069 0.529
ENSG00000160049 E019 1047.494487 0.0007936431 5.542772e-39 1.798051e-36 1 10463431 10463620 190 - 2.862 3.076 0.709
ENSG00000160049 E020 1098.394744 0.0015808296 5.501856e-13 1.406436e-11 1 10467190 10467332 143 - 2.935 3.074 0.463
ENSG00000160049 E021 1230.766587 0.0018379004 1.210675e-04 6.189014e-04 1 10469177 10469338 162 - 3.032 3.101 0.231
ENSG00000160049 E022 882.487996 0.0048188142 4.325513e-02 9.702291e-02 1 10472323 10472529 207 - 2.897 2.951 0.181