ENSG00000159792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000291041 ENSG00000159792 HEK293_OSMI2_2hA HEK293_TMG_2hB PSKH1 protein_coding protein_coding 35.63802 59.62066 18.81832 4.276775 0.207052 -1.66315 31.418206 51.650285 18.0707186 3.182147 0.1971867 -1.514604 0.89302917 0.8678667 0.96046667 0.0926000 0.003568475 0.003568475 FALSE TRUE
ENST00000575198 ENSG00000159792 HEK293_OSMI2_2hA HEK293_TMG_2hB PSKH1 protein_coding processed_transcript 35.63802 59.62066 18.81832 4.276775 0.207052 -1.66315 3.582419 7.026876 0.2755093 1.167476 0.2755093 -4.623325 0.08555833 0.1164000 0.01446667 -0.1019333 0.056440280 0.003568475   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159792 E001 16.73472 0.0406802163 5.718205e-03 1.786646e-02 16 67893254 67893271 18 + 1.384 1.079 -1.078
ENSG00000159792 E002 41.76399 0.0213102459 5.568898e-04 2.373211e-03 16 67893272 67893300 29 + 1.732 1.475 -0.877
ENSG00000159792 E003 87.17865 0.0058762716 2.431636e-05 1.479434e-04 16 67893301 67893371 71 + 1.996 1.812 -0.620
ENSG00000159792 E004 10.75348 0.0016565299 4.074109e-02 9.239905e-02 16 67903032 67903145 114 + 0.733 1.041 1.180
ENSG00000159792 E005 1042.82734 0.0005826631 3.969959e-17 1.790707e-15 16 67908680 67909706 1027 + 2.989 2.920 -0.228
ENSG00000159792 E006 11.02567 0.0044765308 4.958179e-01 6.325590e-01 16 67909707 67910088 382 + 0.912 1.033 0.451
ENSG00000159792 E007 2606.01182 0.0015610914 5.354088e-16 2.095694e-14 16 67927325 67929676 2352 + 3.244 3.360 0.383