ENSG00000159788

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336727 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding protein_coding 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.6411345 0.03982494 1.35784651 0.02536149 0.07229693 4.7788944 0.11974583 0.006233333 0.242400000 0.236166667 5.958110e-20 5.95811e-20 FALSE TRUE
ENST00000338806 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding protein_coding 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.1046378 0.60802467 0.01320515 0.24058583 0.01320515 -4.7351473 0.01639583 0.094800000 0.002066667 -0.092733333 6.219736e-03 5.95811e-20 FALSE TRUE
ENST00000382788 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding protein_coding 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 1.8877550 2.91438200 1.05557437 0.10979247 0.09935015 -1.4565005 0.30637917 0.417900000 0.192000000 -0.225900000 1.992637e-02 5.95811e-20 FALSE TRUE
ENST00000506631 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding retained_intron 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.4413486 0.21947961 0.52360581 0.07122668 0.04321997 1.2174084 0.07576667 0.029166667 0.095233333 0.066066667 6.306751e-03 5.95811e-20 FALSE TRUE
ENST00000507041 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding retained_intron 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.6197390 0.33148951 0.56927512 0.33148951 0.28465237 0.7624074 0.09800833 0.034800000 0.094366667 0.059566667 5.775147e-01 5.95811e-20 FALSE FALSE
ENST00000510803 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding retained_intron 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.6256795 0.70939527 0.43469570 0.35968298 0.21740934 -0.6939662 0.09958750 0.088266667 0.079033333 -0.009233333 1.000000e+00 5.95811e-20   FALSE
ENST00000511805 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding processed_transcript 6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.8415445 1.18948242 1.01755661 0.35832492 0.19627317 -0.2231941 0.14137917 0.157666667 0.179466667 0.021800000 8.572454e-01 5.95811e-20   FALSE
MSTRG.24481.4 ENSG00000159788 HEK293_OSMI2_2hA HEK293_TMG_2hB RGS12 protein_coding   6.115491 7.286636 5.636042 1.170915 0.4608163 -0.3699916 0.2385733 0.59660481 0.07864820 0.09601224 0.07864820 -2.7745938 0.03685417 0.086566667 0.016366667 -0.070200000 1.271692e-01 5.95811e-20 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159788 E001 0.8921407 0.0138512214 1.275915e-03 4.897049e-03 4 3293021 3293027 7 + 0.550 0.000 -13.758
ENSG00000159788 E002 1.0373134 0.0126576526 4.597685e-04 2.005521e-03 4 3293028 3293035 8 + 0.599 0.000 -16.587
ENSG00000159788 E003 1.1888288 0.0181391108 1.855287e-04 9.014581e-04 4 3293036 3293043 8 + 0.643 0.000 -16.709
ENSG00000159788 E004 6.8506785 0.0025930892 5.871635e-04 2.486229e-03 4 3293044 3293099 56 + 1.096 0.676 -1.614
ENSG00000159788 E005 1.1467936 0.0111352924 6.190820e-01 7.365772e-01 4 3314147 3314906 760 + 0.267 0.351 0.553
ENSG00000159788 E006 0.2998086 0.0297168777 7.110007e-01   4 3314907 3314949 43 + 0.154 0.097 -0.771
ENSG00000159788 E007 0.0000000       4 3316068 3316069 2 +      
ENSG00000159788 E008 36.4611420 0.0152063637 9.000757e-06 6.047548e-05 4 3316070 3316558 489 + 1.753 1.388 -1.248
ENSG00000159788 E009 92.4067035 0.0048191667 4.556609e-08 4.954861e-07 4 3316559 3317845 1287 + 2.098 1.833 -0.890
ENSG00000159788 E010 25.2514933 0.0009253984 6.028848e-03 1.868696e-02 4 3317846 3318038 193 + 1.511 1.311 -0.691
ENSG00000159788 E011 12.4970473 0.0014794871 5.272119e-02 1.139921e-01 4 3318039 3318051 13 + 1.223 1.031 -0.692
ENSG00000159788 E012 0.1515154 0.0426022077 3.007429e-01   4 3342415 3342578 164 + 0.154 0.000 -13.808
ENSG00000159788 E013 24.7597761 0.0008664999 5.914220e-03 1.838460e-02 4 3342937 3343053 117 + 1.511 1.311 -0.692
ENSG00000159788 E014 0.0000000       4 3343054 3343189 136 +      
ENSG00000159788 E015 0.5202097 0.0203893164 3.158534e-01 4.586238e-01 4 3369879 3370185 307 + 0.267 0.097 -1.766
ENSG00000159788 E016 0.3332198 0.0284549548 7.132605e-01   4 3370186 3370321 136 + 0.154 0.097 -0.767
ENSG00000159788 E017 13.2148388 0.0021948381 2.925401e-01 4.335105e-01 4 3378170 3378591 422 + 1.189 1.079 -0.394
ENSG00000159788 E018 0.0000000       4 3385146 3385424 279 +      
ENSG00000159788 E019 0.0000000       4 3385604 3385651 48 +      
ENSG00000159788 E020 0.0000000       4 3385681 3385698 18 +      
ENSG00000159788 E021 0.0000000       4 3385699 3385793 95 +      
ENSG00000159788 E022 0.0000000       4 3385794 3385816 23 +      
ENSG00000159788 E023 0.0000000       4 3385971 3386415 445 +      
ENSG00000159788 E024 13.3762234 0.0013427260 1.702261e-01 2.884841e-01 4 3386416 3386437 22 + 1.223 1.087 -0.486
ENSG00000159788 E025 0.1515154 0.0426022077 3.007429e-01   4 3407355 3407573 219 + 0.154 0.000 -13.808
ENSG00000159788 E026 0.3332198 0.0284549548 7.132605e-01   4 3412986 3413228 243 + 0.154 0.097 -0.767
ENSG00000159788 E027 0.3332198 0.0284549548 7.132605e-01   4 3413229 3413703 475 + 0.154 0.097 -0.767
ENSG00000159788 E028 0.0000000       4 3413704 3414071 368 +      
ENSG00000159788 E029 25.4104242 0.0009099366 7.209305e-01 8.154648e-01 4 3414072 3414241 170 + 1.416 1.379 -0.126
ENSG00000159788 E030 0.3729606 0.0285850439 7.135953e-01 8.100455e-01 4 3414242 3414751 510 + 0.154 0.097 -0.765
ENSG00000159788 E031 19.7576919 0.0041287638 2.677699e-01 4.061148e-01 4 3414752 3414844 93 + 1.223 1.307 0.295
ENSG00000159788 E032 31.0343626 0.0007064675 8.892629e-01 9.332172e-01 4 3415978 3416121 144 + 1.475 1.473 -0.009
ENSG00000159788 E033 35.8866157 0.0006493169 6.307071e-01 7.458525e-01 4 3416913 3417092 180 + 1.564 1.524 -0.137
ENSG00000159788 E034 0.7771569 0.0154727591 5.566427e-02 1.191210e-01 4 3417370 3417387 18 + 0.431 0.097 -2.768
ENSG00000159788 E035 34.6965323 0.0006912600 9.483432e-01 9.715805e-01 4 3417388 3417512 125 + 1.533 1.518 -0.053
ENSG00000159788 E036 21.7456505 0.0010921737 6.915799e-01 7.930232e-01 4 3417513 3417541 29 + 1.312 1.332 0.067
ENSG00000159788 E037 19.3668863 0.0017231218 3.234030e-10 5.235215e-09 4 3417542 3419510 1969 + 1.544 1.041 -1.766
ENSG00000159788 E038 5.5952639 0.0274204604 7.700216e-01 8.515125e-01 4 3420388 3420641 254 + 0.814 0.763 -0.203
ENSG00000159788 E039 29.2991698 0.0007564282 6.559094e-01 7.657068e-01 4 3420642 3420718 77 + 1.475 1.435 -0.140
ENSG00000159788 E040 40.2272265 0.0005774332 9.366888e-01 9.641873e-01 4 3422376 3422514 139 + 1.589 1.582 -0.024
ENSG00000159788 E041 20.1326916 0.0009983330 1.074488e-01 2.017791e-01 4 3422515 3422534 20 + 1.212 1.332 0.420
ENSG00000159788 E042 18.5001463 0.0010117747 2.317187e-01 3.645075e-01 4 3422535 3422552 18 + 1.200 1.289 0.313
ENSG00000159788 E043 17.1673819 0.0010973086 3.017051e-01 4.435152e-01 4 3422553 3422570 18 + 1.176 1.254 0.276
ENSG00000159788 E044 16.3493433 0.0011525137 8.540686e-01 9.097153e-01 4 3422905 3422929 25 + 1.212 1.216 0.016
ENSG00000159788 E045 23.2363554 0.0009006728 3.243119e-01 4.676636e-01 4 3422930 3422978 49 + 1.312 1.375 0.217
ENSG00000159788 E046 40.1664953 0.0006080958 4.830121e-02 1.061619e-01 4 3423515 3423641 127 + 1.511 1.615 0.354
ENSG00000159788 E047 0.2998086 0.0297168777 7.110007e-01   4 3423642 3423865 224 + 0.154 0.097 -0.771
ENSG00000159788 E048 0.7771569 0.0154727591 5.566427e-02 1.191210e-01 4 3425446 3425463 18 + 0.431 0.097 -2.768
ENSG00000159788 E049 38.9278128 0.0010346071 6.042257e-01 7.248252e-01 4 3425464 3425560 97 + 1.603 1.561 -0.142
ENSG00000159788 E050 0.7728880 0.0163911197 1.047129e-01 1.976855e-01 4 3426606 3426754 149 + 0.000 0.301 13.736
ENSG00000159788 E051 0.2934659 0.0299728563 7.118258e-01   4 3428089 3428089 1 + 0.154 0.097 -0.770
ENSG00000159788 E052 32.0761865 0.0091768839 4.254572e-01 5.683974e-01 4 3428090 3428169 80 + 1.544 1.471 -0.249
ENSG00000159788 E053 1.5435884 0.2079332788 8.878430e-01 9.323038e-01 4 3428170 3428557 388 + 0.431 0.356 -0.419
ENSG00000159788 E054 34.8224092 0.0031133054 7.721897e-02 1.550312e-01 4 3428558 3428711 154 + 1.456 1.563 0.367
ENSG00000159788 E055 90.0596991 0.0004064726 3.191401e-10 5.172395e-09 4 3430407 3430955 549 + 1.750 1.995 0.825
ENSG00000159788 E056 112.8464620 0.0023141016 9.924121e-24 9.548476e-22 4 3430956 3432250 1295 + 1.697 2.130 1.457
ENSG00000159788 E057 34.4016532 0.0029471360 3.409833e-01 4.849136e-01 4 3439455 3440030 576 + 1.487 1.540 0.179
ENSG00000159788 E058 0.2998086 0.0297168777 7.110007e-01   4 3441633 3441683 51 + 0.154 0.097 -0.771