ENSG00000159592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290795 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding protein_coding 35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 2.890592 2.618232 1.988797 1.1975182 0.3110153 -0.39496073 0.08831667 0.10286667 0.04220000 -0.06066667 0.1533052720 0.0001900264 FALSE TRUE
ENST00000355105 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding protein_coding 35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 7.590281 5.683282 9.349853 0.3984707 0.6765362 0.71722537 0.22194583 0.25106667 0.19773333 -0.05333333 0.4840079854 0.0001900264 FALSE TRUE
ENST00000460859 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding processed_transcript 35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 1.100303 0.337067 3.059536 0.1895906 0.3049038 3.14473458 0.02602083 0.01343333 0.06443333 0.05100000 0.0813490236 0.0001900264   FALSE
ENST00000467032 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding processed_transcript 35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 4.193132 4.164490 4.718071 0.8674033 0.8796443 0.17965187 0.12907917 0.17816667 0.09963333 -0.07853333 0.1753825948 0.0001900264   FALSE
MSTRG.1090.1 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding   35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 5.160067 6.124654 5.731910 1.3600901 1.0484379 -0.09545135 0.16135833 0.25890000 0.12040000 -0.13850000 0.0080715864 0.0001900264 FALSE TRUE
MSTRG.1090.12 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding   35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 3.749697 1.316892 6.801750 0.2520316 0.6361976 2.35997453 0.09049583 0.06180000 0.14356667 0.08176667 0.0812217190 0.0001900264 FALSE TRUE
MSTRG.1090.7 ENSG00000159592 HEK293_OSMI2_2hA HEK293_TMG_2hB GPBP1L1 protein_coding   35.57326 23.29563 47.3819 3.481116 0.6925867 1.023962 8.451204 2.369551 12.792444 0.3089549 0.1808089 2.42765794 0.21020000 0.10633333 0.27003333 0.16370000 0.0001900264 0.0001900264 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159592 E001 289.438638 0.0027285478 2.593735e-22 2.142002e-20 1 45627304 45627953 650 - 2.302 2.617 1.049
ENSG00000159592 E002 95.914600 0.0003919221 4.506938e-10 7.117560e-09 1 45627954 45627956 3 - 1.876 2.107 0.776
ENSG00000159592 E003 334.181633 0.0020160694 9.452179e-08 9.638231e-07 1 45627957 45628227 271 - 2.453 2.607 0.512
ENSG00000159592 E004 321.605931 0.0001904129 2.154360e-04 1.030259e-03 1 45628228 45628408 181 - 2.475 2.554 0.261
ENSG00000159592 E005 152.436202 0.0002666996 9.222934e-04 3.692975e-03 1 45629576 45629587 12 - 2.143 2.243 0.335
ENSG00000159592 E006 170.261420 0.0015263190 4.773132e-02 1.051435e-01 1 45629588 45629613 26 - 2.204 2.274 0.231
ENSG00000159592 E007 219.063101 0.0020590601 5.182596e-02 1.124144e-01 1 45629614 45629678 65 - 2.314 2.381 0.225
ENSG00000159592 E008 2.777256 0.0917302653 4.979515e-01 6.344766e-01 1 45629679 45629715 37 - 0.631 0.490 -0.647
ENSG00000159592 E009 307.024425 0.0014238837 9.801199e-01 9.915932e-01 1 45630482 45630606 125 - 2.486 2.489 0.008
ENSG00000159592 E010 1.036178 0.0585399206 1.637426e-01 2.800117e-01 1 45630607 45630757 151 - 0.177 0.429 1.746
ENSG00000159592 E011 292.400108 0.0001620224 5.137159e-01 6.484923e-01 1 45633489 45633593 105 - 2.471 2.461 -0.035
ENSG00000159592 E012 199.811581 0.0020664305 7.263695e-01 8.194202e-01 1 45633594 45633647 54 - 2.307 2.295 -0.039
ENSG00000159592 E013 3.218097 0.0078804980 3.942168e-01 5.380866e-01 1 45633648 45633675 28 - 0.679 0.547 -0.580
ENSG00000159592 E014 2.508999 0.0077170980 2.516003e-03 8.811823e-03 1 45633676 45633831 156 - 0.701 0.153 -3.257
ENSG00000159592 E015 248.768845 0.0001644766 7.124957e-01 8.092143e-01 1 45634096 45634236 141 - 2.399 2.394 -0.016
ENSG00000159592 E016 6.268041 0.0048533217 5.188579e-01 6.529918e-01 1 45634237 45635724 1488 - 0.892 0.811 -0.311
ENSG00000159592 E017 246.811728 0.0002055530 1.810841e-01 3.025745e-01 1 45640210 45640403 194 - 2.378 2.412 0.114
ENSG00000159592 E018 0.000000       1 45641670 45641811 142 -      
ENSG00000159592 E019 151.206621 0.0009384717 4.402164e-01 5.819028e-01 1 45642427 45642499 73 - 2.170 2.197 0.093
ENSG00000159592 E020 1.607406 0.4069608853 9.880148e-01 9.965523e-01 1 45654271 45654542 272 - 0.439 0.362 -0.429
ENSG00000159592 E021 337.440419 0.0014554948 2.615673e-03 9.113052e-03 1 45654543 45654829 287 - 2.559 2.476 -0.277
ENSG00000159592 E022 238.503566 0.0001872156 5.684079e-08 6.051996e-07 1 45655190 45655319 130 - 2.428 2.302 -0.420
ENSG00000159592 E023 5.578159 0.0997619783 7.431253e-01 8.318730e-01 1 45655320 45656159 840 - 0.849 0.774 -0.293
ENSG00000159592 E024 3.002051 0.0051546638 9.213138e-02 1.784445e-01 1 45658755 45659027 273 - 0.701 0.429 -1.258
ENSG00000159592 E025 184.674374 0.0003766002 3.041774e-05 1.807178e-04 1 45659028 45659142 115 - 2.314 2.202 -0.372
ENSG00000159592 E026 217.503600 0.0002170366 8.937149e-04 3.592057e-03 1 45660184 45660416 233 - 2.370 2.291 -0.264
ENSG00000159592 E027 127.098899 0.0003983151 1.392422e-01 2.470154e-01 1 45660417 45660529 113 - 2.123 2.078 -0.151
ENSG00000159592 E028 83.794636 0.0004277330 1.122936e-01 2.088932e-01 1 45660530 45660548 19 - 1.948 1.888 -0.204
ENSG00000159592 E029 167.712803 0.0007838438 4.104455e-02 9.296487e-02 1 45660549 45660676 128 - 2.249 2.187 -0.208
ENSG00000159592 E030 147.143180 0.0031832213 1.777752e-01 2.983370e-01 1 45660677 45660797 121 - 2.191 2.131 -0.202
ENSG00000159592 E031 316.963687 0.0046466271 4.076676e-06 2.958491e-05 1 45660798 45661225 428 - 2.567 2.379 -0.626
ENSG00000159592 E032 65.992890 0.0118340766 1.091755e-03 4.276167e-03 1 45685576 45685620 45 - 1.907 1.660 -0.831
ENSG00000159592 E033 58.959960 0.0073975776 1.472663e-02 3.987474e-02 1 45686412 45686653 242 - 1.833 1.674 -0.537
ENSG00000159592 E034 55.262932 0.0070578783 9.704835e-12 2.026846e-10 1 45686993 45687146 154 - 1.886 1.406 -1.635
ENSG00000159592 E035 8.954735 0.0018652342 1.314175e-04 6.650854e-04 1 45687983 45688113 131 - 1.141 0.680 -1.760