ENSG00000159579

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394420 ENSG00000159579 HEK293_OSMI2_2hA HEK293_TMG_2hB RSPRY1 protein_coding protein_coding 12.81497 5.971405 18.68364 0.6917166 0.8441048 1.643991 5.1901573 2.3523015 7.307790 0.08703779 0.1590053 1.631215 0.4004042 0.40400000 0.3923333 -0.01166667 1.000000e+00 2.217161e-26 FALSE TRUE
ENST00000537866 ENSG00000159579 HEK293_OSMI2_2hA HEK293_TMG_2hB RSPRY1 protein_coding protein_coding 12.81497 5.971405 18.68364 0.6917166 0.8441048 1.643991 1.8752172 0.5566688 3.314481 0.09427573 0.5354774 2.552551 0.1453167 0.09783333 0.1767333 0.07890000 2.197078e-01 2.217161e-26 FALSE TRUE
ENST00000561641 ENSG00000159579 HEK293_OSMI2_2hA HEK293_TMG_2hB RSPRY1 protein_coding protein_coding 12.81497 5.971405 18.68364 0.6917166 0.8441048 1.643991 0.8582454 0.2270355 1.936434 0.17883184 0.0327103 3.037658 0.0555000 0.03293333 0.1040667 0.07113333 1.988685e-01 2.217161e-26 FALSE FALSE
ENST00000563073 ENSG00000159579 HEK293_OSMI2_2hA HEK293_TMG_2hB RSPRY1 protein_coding processed_transcript 12.81497 5.971405 18.68364 0.6917166 0.8441048 1.643991 0.5986076 1.9858112 0.000000 0.52304149 0.0000000 -7.640831 0.1016958 0.32246667 0.0000000 -0.32246667 2.217161e-26 2.217161e-26 FALSE FALSE
MSTRG.12717.5 ENSG00000159579 HEK293_OSMI2_2hA HEK293_TMG_2hB RSPRY1 protein_coding   12.81497 5.971405 18.68364 0.6917166 0.8441048 1.643991 2.2006600 0.4950147 3.140317 0.29453906 0.3104059 2.641100 0.1533333 0.07660000 0.1679667 0.09136667 4.815574e-01 2.217161e-26 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159579 E001 0.7322062 0.2430063795 3.084234e-01 4.507053e-01 16 57186137 57186235 99 + 0.268 0.000 -9.964
ENSG00000159579 E002 0.0000000       16 57186281 57186283 3 +      
ENSG00000159579 E003 0.4418608 0.0248339672 4.657559e-01 6.053808e-01 16 57186284 57186306 23 + 0.180 0.000 -11.411
ENSG00000159579 E004 0.4418608 0.0248339672 4.657559e-01 6.053808e-01 16 57186307 57186310 4 + 0.180 0.000 -11.411
ENSG00000159579 E005 2.9747060 0.0620615806 1.613584e-01 2.768568e-01 16 57186311 57186328 18 + 0.610 0.349 -1.317
ENSG00000159579 E006 4.7764908 0.0701874254 8.764309e-02 1.715532e-01 16 57186329 57186332 4 + 0.775 0.455 -1.419
ENSG00000159579 E007 25.7476260 0.0223186723 3.143287e-01 4.570397e-01 16 57186333 57186429 97 + 1.382 1.330 -0.179
ENSG00000159579 E008 21.7357230 0.0419058637 3.839631e-01 5.281741e-01 16 57186430 57186442 13 + 1.311 1.261 -0.175
ENSG00000159579 E009 20.4887063 0.0142199779 2.729523e-01 4.119268e-01 16 57186443 57186451 9 + 1.289 1.232 -0.202
ENSG00000159579 E010 45.3272950 0.0017411950 4.965899e-03 1.583503e-02 16 57186452 57186785 334 + 1.634 1.512 -0.416
ENSG00000159579 E011 17.5587990 0.0422707943 2.076694e-01 3.356827e-01 16 57186786 57186921 136 + 1.236 1.110 -0.450
ENSG00000159579 E012 15.2299654 0.0013560483 1.072066e-02 3.050096e-02 16 57186922 57187050 129 + 1.201 0.985 -0.782
ENSG00000159579 E013 44.7149141 0.0044506876 7.739145e-02 1.552870e-01 16 57204504 57204596 93 + 1.617 1.558 -0.200
ENSG00000159579 E014 139.0163255 0.0002468540 2.436099e-07 2.296420e-06 16 57204597 57205008 412 + 2.115 1.994 -0.403
ENSG00000159579 E015 3.6224816 0.0044813197 7.853282e-01 8.623916e-01 16 57205009 57205269 261 + 0.611 0.612 0.007
ENSG00000159579 E016 7.9340835 0.0020809885 4.770369e-02 1.050900e-01 16 57207593 57207685 93 + 0.948 0.727 -0.863
ENSG00000159579 E017 1.1993242 0.2684157694 1.468119e-01 2.573379e-01 16 57208050 57208057 8 + 0.376 0.000 -12.553
ENSG00000159579 E018 50.5482797 0.0004904311 3.140889e-04 1.437102e-03 16 57208058 57208110 53 + 1.685 1.529 -0.532
ENSG00000159579 E019 64.6412703 0.0051212413 2.722057e-02 6.643805e-02 16 57209075 57209187 113 + 1.774 1.698 -0.258
ENSG00000159579 E020 42.9804187 0.0045366260 1.565467e-01 2.704995e-01 16 57212972 57213002 31 + 1.591 1.552 -0.133
ENSG00000159579 E021 56.1023530 0.0004445849 2.210304e-01 3.516496e-01 16 57213003 57213098 96 + 1.697 1.692 -0.016
ENSG00000159579 E022 52.0695185 0.0008245931 9.972112e-01 1.000000e+00 16 57213888 57213946 59 + 1.648 1.709 0.205
ENSG00000159579 E023 61.6228081 0.0025211752 9.670067e-01 9.833216e-01 16 57216107 57216173 67 + 1.719 1.781 0.210
ENSG00000159579 E024 1.1824861 0.0114094088 7.222019e-02 1.470318e-01 16 57216174 57216502 329 + 0.375 0.000 -12.764
ENSG00000159579 E025 84.0637106 0.0008081929 1.043178e-01 1.970644e-01 16 57216904 57217035 132 + 1.871 1.858 -0.042
ENSG00000159579 E026 5.4595160 0.0396445009 3.071613e-02 7.336021e-02 16 57219672 57220731 1060 + 0.823 0.457 -1.599
ENSG00000159579 E027 81.9267645 0.0004017584 1.273583e-02 3.529035e-02 16 57220732 57220847 116 + 1.871 1.819 -0.174
ENSG00000159579 E028 84.2424594 0.0003192724 2.321007e-02 5.818087e-02 16 57221272 57221415 144 + 1.879 1.839 -0.133
ENSG00000159579 E029 0.0000000       16 57224422 57224479 58 +      
ENSG00000159579 E030 66.1870492 0.0062983935 1.318531e-01 2.366932e-01 16 57227342 57227453 112 + 1.773 1.736 -0.127
ENSG00000159579 E031 51.2112242 0.0024022233 8.454685e-01 9.039124e-01 16 57230711 57230813 103 + 1.645 1.693 0.163
ENSG00000159579 E032 79.6242910 0.0003648114 9.272275e-01 9.582150e-01 16 57231167 57231319 153 + 1.829 1.894 0.220
ENSG00000159579 E033 74.1438728 0.0003738924 2.520398e-01 3.883608e-01 16 57235124 57235228 105 + 1.785 1.897 0.380
ENSG00000159579 E034 380.1813675 0.0077995955 5.861990e-12 1.266146e-10 16 57238879 57240469 1591 + 2.419 2.732 1.042