ENSG00000159459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290650 ENSG00000159459 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR1 protein_coding protein_coding 4.689067 1.061629 7.494105 0.07487249 0.1947983 2.807874 3.8625086 0.851422413 6.18366927 0.025349585 0.06767447 2.846002 0.79492083 0.8141667 0.82616667 0.0120000 0.9591259218 0.0002527659 FALSE TRUE
ENST00000546274 ENSG00000159459 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR1 protein_coding protein_coding 4.689067 1.061629 7.494105 0.07487249 0.1947983 2.807874 0.3301277 0.003730073 0.90215449 0.003730073 0.08079829 6.053867 0.04207083 0.0041000 0.12020000 0.1161000 0.0002527659 0.0002527659 FALSE TRUE
ENST00000568782 ENSG00000159459 HEK293_OSMI2_2hA HEK293_TMG_2hB UBR1 protein_coding processed_transcript 4.689067 1.061629 7.494105 0.07487249 0.1947983 2.807874 0.1403109 0.206476810 0.08482897 0.103257643 0.08482897 -1.190813 0.07257500 0.1817333 0.01176667 -0.1699667 0.2338011111 0.0002527659 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159459 E001 196.3549694 0.0004591760 1.417063e-36 3.885069e-34 15 42942897 42945186 2290 - 2.054 2.433 1.266
ENSG00000159459 E002 49.6706715 0.0143325026 7.210945e-01 8.155821e-01 15 42945187 42945470 284 - 1.538 1.581 0.148
ENSG00000159459 E003 21.2084583 0.0656083646 6.110693e-01 7.302603e-01 15 42950262 42950363 102 - 1.175 1.292 0.414
ENSG00000159459 E004 0.0000000       15 42950364 42950574 211 -      
ENSG00000159459 E005 32.3978113 0.0006298192 1.028845e-01 1.948726e-01 15 42952278 42952448 171 - 1.341 1.482 0.487
ENSG00000159459 E006 21.8459756 0.0035013263 6.073899e-02 1.278733e-01 15 42958013 42958090 78 - 1.169 1.361 0.676
ENSG00000159459 E007 20.6288829 0.0009483927 4.993253e-02 1.090516e-01 15 42960645 42960701 57 - 1.144 1.344 0.703
ENSG00000159459 E008 20.0225127 0.0008873268 2.853258e-01 4.256347e-01 15 42963935 42964043 109 - 1.148 1.265 0.414
ENSG00000159459 E009 25.4642684 0.0027888737 4.163847e-02 9.407275e-02 15 42966153 42966286 134 - 1.232 1.426 0.675
ENSG00000159459 E010 27.5878368 0.0150810099 2.869410e-01 4.273896e-01 15 42970520 42970607 88 - 1.279 1.394 0.400
ENSG00000159459 E011 35.4441741 0.0006132798 2.601689e-01 3.976492e-01 15 42976717 42976867 151 - 1.384 1.482 0.335
ENSG00000159459 E012 17.7790548 0.0010180464 2.781597e-01 4.177925e-01 15 42977880 42977947 68 - 1.095 1.220 0.445
ENSG00000159459 E013 19.5199824 0.0009517451 6.802097e-01 7.841550e-01 15 42983897 42983993 97 - 1.144 1.195 0.180
ENSG00000159459 E014 17.2939300 0.0045627446 8.270147e-01 8.911889e-01 15 42984887 42984942 56 - 1.103 1.080 -0.083
ENSG00000159459 E015 0.2924217 0.0272640671 1.000000e+00   15 42988493 42988818 326 - 0.090 0.000 -9.138
ENSG00000159459 E016 25.5302877 0.0007506315 3.333006e-01 4.769994e-01 15 42988819 42988967 149 - 1.247 1.344 0.340
ENSG00000159459 E017 13.0531597 0.0073358751 5.573110e-01 6.857480e-01 15 42990030 42990120 91 - 1.001 0.921 -0.299
ENSG00000159459 E018 17.9162069 0.0010251154 2.786827e-01 4.183453e-01 15 42998168 42998265 98 - 1.137 1.007 -0.473
ENSG00000159459 E019 24.6786170 0.0008031910 1.403896e-01 2.485704e-01 15 43002555 43002704 150 - 1.269 1.111 -0.561
ENSG00000159459 E020 0.0000000       15 43003254 43003386 133 -      
ENSG00000159459 E021 23.0392903 0.0008358332 8.696676e-01 9.201825e-01 15 43003837 43003930 94 - 1.220 1.243 0.079
ENSG00000159459 E022 33.6234274 0.0026201186 5.705512e-01 6.969991e-01 15 43007079 43007284 206 - 1.370 1.425 0.193
ENSG00000159459 E023 0.2998086 0.0292613059 1.387020e-01   15 43015656 43015687 32 - 0.048 0.282 2.984
ENSG00000159459 E024 32.6824213 0.0005982651 2.390575e-01 3.730061e-01 15 43015688 43015869 182 - 1.350 1.455 0.362
ENSG00000159459 E025 23.9930351 0.0008351547 2.813786e-02 6.828630e-02 15 43017095 43017181 87 - 1.263 1.007 -0.920
ENSG00000159459 E026 0.1515154 0.0433703526 7.096600e-01   15 43021081 43021084 4 - 0.048 0.000 -8.157
ENSG00000159459 E027 0.2966881 0.0270926356 1.000000e+00   15 43021085 43021274 190 - 0.090 0.000 -9.138
ENSG00000159459 E028 26.1652362 0.0008330037 2.630677e-01 4.009323e-01 15 43021275 43021375 101 - 1.282 1.169 -0.401
ENSG00000159459 E029 22.0844555 0.0117492388 9.637261e-01 9.811053e-01 15 43022702 43022801 100 - 1.199 1.197 -0.009
ENSG00000159459 E030 31.1630360 0.0006520113 2.758363e-02 6.717965e-02 15 43024829 43024983 155 - 1.365 1.141 -0.791
ENSG00000159459 E031 0.0000000       15 43025374 43025380 7 -      
ENSG00000159459 E032 21.9877239 0.0008411160 1.426336e-02 3.882456e-02 15 43025381 43025429 49 - 1.229 0.921 -1.122
ENSG00000159459 E033 0.4396707 0.0291398139 1.000000e+00 1.000000e+00 15 43025430 43026560 1131 - 0.129 0.000 -9.718
ENSG00000159459 E034 25.4892604 0.0007492883 3.306473e-02 7.793775e-02 15 43026561 43026663 103 - 1.285 1.045 -0.858
ENSG00000159459 E035 19.8247716 0.0354564162 4.766858e-02 1.050273e-01 15 43027776 43027828 53 - 1.189 0.872 -1.166
ENSG00000159459 E036 25.2690748 0.0008412720 7.125045e-03 2.154951e-02 15 43029944 43030068 125 - 1.287 0.966 -1.156
ENSG00000159459 E037 17.5095566 0.0010078020 1.010074e-01 1.919987e-01 15 43032568 43032631 64 - 1.134 0.921 -0.782
ENSG00000159459 E038 24.6204539 0.0036896447 9.363942e-02 1.808145e-01 15 43036178 43036279 102 - 1.269 1.079 -0.677
ENSG00000159459 E039 20.0375943 0.0009121723 3.860113e-01 5.302056e-01 15 43036528 43036593 66 - 1.176 1.079 -0.347
ENSG00000159459 E040 26.6833125 0.0007928361 7.148191e-02 1.458041e-01 15 43037773 43037883 111 - 1.303 1.111 -0.680
ENSG00000159459 E041 22.0679627 0.0008101154 2.849312e-02 6.899995e-02 15 43038171 43038232 62 - 1.232 0.966 -0.963
ENSG00000159459 E042 0.0000000       15 43043214 43043214 1 -      
ENSG00000159459 E043 28.5073702 0.0007319125 7.841803e-03 2.338506e-02 15 43043215 43043343 129 - 1.339 1.044 -1.046
ENSG00000159459 E044 20.3914791 0.0008897130 4.178176e-03 1.364447e-02 15 43043344 43043395 52 - 1.205 0.813 -1.451
ENSG00000159459 E045 30.0737644 0.0010131799 4.059750e-03 1.330912e-02 15 43047161 43047289 129 - 1.361 1.045 -1.124
ENSG00000159459 E046 22.3691893 0.0080474012 1.348441e-01 2.408845e-01 15 43048392 43048491 100 - 1.229 1.045 -0.660
ENSG00000159459 E047 26.9803970 0.0082428920 6.550316e-01 7.650240e-01 15 43054742 43054899 158 - 1.290 1.244 -0.162
ENSG00000159459 E048 19.1925944 0.0010360724 6.932676e-01 7.943240e-01 15 43056344 43056442 99 - 1.152 1.111 -0.146
ENSG00000159459 E049 21.0401085 0.0009191687 6.334664e-01 7.481722e-01 15 43058341 43058429 89 - 1.189 1.141 -0.172
ENSG00000159459 E050 19.7834262 0.0011423163 6.043028e-01 7.248946e-01 15 43059085 43059192 108 - 1.166 1.111 -0.196
ENSG00000159459 E051 18.5006847 0.0009551745 2.289045e-01 3.611395e-01 15 43059702 43059825 124 - 1.152 1.007 -0.525
ENSG00000159459 E052 21.7374831 0.0008563621 7.171783e-02 1.462088e-01 15 43060052 43060114 63 - 1.220 1.007 -0.768
ENSG00000159459 E053 28.6902045 0.0006820959 3.653770e-02 8.460085e-02 15 43067898 43068036 139 - 1.332 1.111 -0.780
ENSG00000159459 E054 27.1710620 0.0015510699 6.705705e-02 1.384711e-01 15 43070795 43070898 104 - 1.308 1.111 -0.696
ENSG00000159459 E055 18.2466925 0.0043677326 8.647667e-02 1.697694e-01 15 43070899 43070925 27 - 1.148 0.921 -0.832
ENSG00000159459 E056 26.9306787 0.0035570851 3.786119e-03 1.254339e-02 15 43074979 43075089 111 - 1.317 0.966 -1.260
ENSG00000159459 E057 22.4614621 0.0059564678 5.334298e-04 2.284799e-03 15 43082638 43082710 73 - 1.252 0.747 -1.880
ENSG00000159459 E058 14.2014665 0.0078367073 4.792326e-02 1.054904e-01 15 43082711 43082716 6 - 1.057 0.747 -1.182
ENSG00000159459 E059 40.7528704 0.0005136014 1.758491e-03 6.467120e-03 15 43085984 43086240 257 - 1.487 1.195 -1.019
ENSG00000159459 E060 0.0000000       15 43091961 43091972 12 -      
ENSG00000159459 E061 0.0000000       15 43091973 43092080 108 -      
ENSG00000159459 E062 20.6782390 0.0043066134 1.153629e-01 2.133835e-01 15 43105942 43106113 172 - 1.199 1.007 -0.693