ENSG00000159433

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290607 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding protein_coding 1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.66917798 0.24931075 0.72808218 0.04557107 0.03154603 1.509099 0.44195000 0.17686667 0.7168667 0.54000000 3.139274e-09 3.139274e-09 FALSE TRUE
ENST00000562619 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding nonsense_mediated_decay 1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.35651338 0.29705259 0.13096427 0.04277555 0.02987495 -1.123156 0.18861667 0.21433333 0.1263667 -0.08796667 4.207575e-01 3.139274e-09 TRUE TRUE
ENST00000563872 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding retained_intron 1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.08859001 0.12170882 0.00000000 0.12170882 0.00000000 -3.719280 0.04898750 0.07826667 0.0000000 -0.07826667 8.027923e-01 3.139274e-09 FALSE TRUE
ENST00000564158 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding retained_intron 1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.03771662 0.01734632 0.09018726 0.01734632 0.04644797 1.873281 0.02757917 0.01516667 0.0865000 0.07133333 4.247271e-01 3.139274e-09 TRUE TRUE
MSTRG.10625.10 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding   1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.05776426 0.09185959 0.00000000 0.09185959 0.00000000 -3.348510 0.03390417 0.08026667 0.0000000 -0.08026667 8.066619e-01 3.139274e-09 TRUE TRUE
MSTRG.10625.7 ENSG00000159433 HEK293_OSMI2_2hA HEK293_TMG_2hB STARD9 protein_coding   1.659011 1.383879 1.020277 0.123472 0.07622718 -0.4360722 0.28946479 0.56256774 0.00000000 0.14312466 0.00000000 -5.839374 0.16036250 0.40490000 0.0000000 -0.40490000 2.527284e-06 3.139274e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159433 E001 0.4427912 0.1266615114 6.251838e-01 7.413570e-01 15 42575606 42575658 53 + 0.207 0.128 -0.828
ENSG00000159433 E002 0.8908930 0.2839889097 9.516167e-01 9.737015e-01 15 42575659 42575669 11 + 0.283 0.301 0.124
ENSG00000159433 E003 4.5090024 0.0079229848 7.632740e-01 8.466388e-01 15 42575670 42575762 93 + 0.697 0.768 0.290
ENSG00000159433 E004 3.5867865 0.0046572178 2.374197e-01 3.711798e-01 15 42583346 42583415 70 + 0.537 0.741 0.883
ENSG00000159433 E005 4.5726135 0.0049122153 2.636237e-02 6.467087e-02 15 42585521 42585634 114 + 0.537 0.880 1.429
ENSG00000159433 E006 1.6198875 0.0131661294 1.859293e-01 3.086527e-01 15 42585635 42585637 3 + 0.283 0.534 1.402
ENSG00000159433 E007 0.0000000       15 42629842 42630146 305 +      
ENSG00000159433 E008 3.4310193 0.0048181147 4.558531e-01 5.963470e-01 15 42634856 42634972 117 + 0.574 0.712 0.596
ENSG00000159433 E009 1.3598208 0.1757910504 9.453062e-01 9.696752e-01 15 42637907 42637939 33 + 0.347 0.382 0.204
ENSG00000159433 E010 1.9435434 0.1303140961 6.311150e-01 7.462091e-01 15 42638026 42638087 62 + 0.403 0.533 0.659
ENSG00000159433 E011 0.1472490 0.0421922326 5.076103e-01   15 42638088 42638151 64 + 0.116 0.000 -10.237
ENSG00000159433 E012 0.5891098 0.0185023052 4.089616e-02 9.269527e-02 15 42638646 42638699 54 + 0.347 0.000 -12.136
ENSG00000159433 E013 2.0951475 0.0067987768 4.554502e-01 5.959795e-01 15 42638700 42638812 113 + 0.537 0.437 -0.496
ENSG00000159433 E014 2.2111634 0.0065700160 3.595569e-02 8.349708e-02 15 42651016 42651085 70 + 0.640 0.310 -1.692
ENSG00000159433 E015 2.6444914 0.0099949791 8.663298e-03 2.544118e-02 15 42652520 42652592 73 + 0.722 0.310 -2.039
ENSG00000159433 E016 3.7464360 0.0065386502 5.338409e-03 1.685267e-02 15 42661158 42661225 68 + 0.833 0.437 -1.743
ENSG00000159433 E017 4.8921749 0.0089062456 6.370952e-04 2.670142e-03 15 42662794 42662891 98 + 0.951 0.488 -1.933
ENSG00000159433 E018 1.0393897 0.0121775798 4.353522e-03 1.413158e-02 15 42662892 42663280 389 + 0.497 0.000 -12.821
ENSG00000159433 E019 6.3787214 0.0026337625 1.090462e-04 5.636691e-04 15 42663281 42663490 210 + 1.045 0.577 -1.862
ENSG00000159433 E020 0.7384352 0.0166726768 1.925550e-02 4.988985e-02 15 42663491 42663819 329 + 0.403 0.000 -12.413
ENSG00000159433 E021 4.2221875 0.0096039577 1.444831e-03 5.455936e-03 15 42663820 42663917 98 + 0.888 0.437 -1.955
ENSG00000159433 E022 3.4900976 0.0342803006 1.411547e-04 7.085673e-04 15 42665253 42665330 78 + 0.871 0.229 -3.211
ENSG00000159433 E023 2.5269804 0.0620027326 2.737732e-02 6.675911e-02 15 42665786 42665806 21 + 0.697 0.311 -1.929
ENSG00000159433 E024 2.9645748 0.0150298618 3.440697e-03 1.155460e-02 15 42665807 42665848 42 + 0.770 0.310 -2.232
ENSG00000159433 E025 3.2288970 0.0123665561 1.610131e-04 7.964969e-04 15 42669158 42669337 180 + 0.833 0.229 -3.065
ENSG00000159433 E026 1.9483779 0.8127049841 7.819225e-01 8.599676e-01 15 42669338 42673114 3777 + 0.501 0.434 -0.338
ENSG00000159433 E027 0.9922594 0.0129325512 4.463927e-01 5.878885e-01 15 42673925 42673963 39 + 0.347 0.229 -0.817
ENSG00000159433 E028 1.8779687 0.0092650514 2.828578e-01 4.229112e-01 15 42674440 42674491 52 + 0.537 0.378 -0.819
ENSG00000159433 E029 2.3843470 0.0067846159 4.964973e-01 6.331359e-01 15 42674827 42674964 138 + 0.574 0.488 -0.403
ENSG00000159433 E030 0.0000000       15 42675496 42675663 168 +      
ENSG00000159433 E031 2.0198054 0.0495421836 5.019775e-01 6.381148e-01 15 42675664 42675746 83 + 0.537 0.436 -0.501
ENSG00000159433 E032 2.3059862 0.2083959569 9.729359e-02 1.863529e-01 15 42675872 42675975 104 + 0.668 0.311 -1.804
ENSG00000159433 E033 3.3109325 0.0050140413 3.028683e-03 1.035060e-02 15 42681422 42681612 191 + 0.813 0.378 -1.989
ENSG00000159433 E034 5.4941221 0.0502717596 7.257368e-03 2.189484e-02 15 42682104 42682575 472 + 0.980 0.575 -1.633
ENSG00000159433 E035 38.4685192 0.0081610743 3.197832e-12 7.226765e-11 15 42684116 42686984 2869 + 1.769 1.312 -1.565
ENSG00000159433 E036 3.7235427 0.0042261489 6.066023e-01 7.266914e-01 15 42686985 42687075 91 + 0.697 0.650 -0.197
ENSG00000159433 E037 37.5997787 0.0006424925 1.253720e-11 2.569103e-10 15 42687076 42689594 2519 + 1.729 1.378 -1.200
ENSG00000159433 E038 40.6415258 0.0040839590 5.104670e-03 1.621557e-02 15 42689595 42691586 1992 + 1.679 1.549 -0.443
ENSG00000159433 E039 94.4029554 0.0007711034 8.052034e-02 1.603643e-01 15 42691587 42694342 2756 + 1.919 2.015 0.324
ENSG00000159433 E040 1.8883493 0.0969365517 9.427360e-01 9.680384e-01 15 42694460 42694527 68 + 0.453 0.485 0.163
ENSG00000159433 E041 16.2844900 0.0533045471 1.784490e-03 6.549769e-03 15 42694528 42694725 198 + 0.952 1.398 1.594
ENSG00000159433 E042 15.7677922 0.0013323878 3.637502e-05 2.117484e-04 15 42695140 42695323 184 + 0.966 1.365 1.428
ENSG00000159433 E043 13.3110865 0.0014091973 3.658933e-06 2.687033e-05 15 42695743 42695880 138 + 0.833 1.317 1.768
ENSG00000159433 E044 11.0388077 0.0052500587 1.218192e-03 4.701889e-03 15 42716677 42716764 88 + 0.833 1.212 1.398
ENSG00000159433 E045 12.7091506 0.0049943508 8.174233e-02 1.622862e-01 15 42716927 42717048 122 + 1.007 1.212 0.739
ENSG00000159433 E046 9.9057475 0.0144219670 9.036821e-02 1.756995e-01 15 42717731 42717795 65 + 0.888 1.122 0.864
ENSG00000159433 E047 16.7594014 0.0031682669 5.837474e-02 1.238429e-01 15 42717977 42718179 203 + 1.121 1.319 0.698
ENSG00000159433 E048 10.4723928 0.0019341850 9.106622e-02 1.768081e-01 15 42718435 42718514 80 + 0.936 1.141 0.748
ENSG00000159433 E049 15.1682612 0.0245332316 5.096603e-01 6.449635e-01 15 42718752 42718910 159 + 1.150 1.255 0.374
ENSG00000159433 E050 77.5405440 0.0318464738 8.265534e-07 6.987731e-06 15 42719473 42722267 2795 + 1.599 2.061 1.558