ENSG00000159399

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290573 ENSG00000159399 HEK293_OSMI2_2hA HEK293_TMG_2hB HK2 protein_coding protein_coding 25.34215 20.22323 26.3369 1.218493 0.596266 0.3809062 21.494301 12.621171 24.600605 1.611185 0.05493189 0.9622917 0.8221542 0.6295333 0.9351333 0.3056000 0.009798059 0.009798059 FALSE TRUE
ENST00000409174 ENSG00000159399 HEK293_OSMI2_2hA HEK293_TMG_2hB HK2 protein_coding protein_coding 25.34215 20.22323 26.3369 1.218493 0.596266 0.3809062 3.532135 7.495774 1.444885 2.203447 0.64464127 -2.3670958 0.1663333 0.3653333 0.0538000 -0.3115333 0.025501298 0.009798059 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159399 E001 0.0000000       2 74832436 74832654 219 +      
ENSG00000159399 E002 0.0000000       2 74832655 74832678 24 +      
ENSG00000159399 E003 0.0000000       2 74832679 74832680 2 +      
ENSG00000159399 E004 3.7473926 0.3748569995 1.952011e-01 3.202448e-01 2 74832681 74834126 1446 + 0.746 0.547 -0.857
ENSG00000159399 E005 198.1298501 0.0097259179 7.763952e-05 4.169113e-04 2 74834127 74834643 517 + 2.340 2.225 -0.383
ENSG00000159399 E006 0.6234634 0.0177276630 2.117503e-01 3.405445e-01 2 74834644 74835169 526 + 0.099 0.351 2.290
ENSG00000159399 E007 2.9067482 0.0470624375 3.397049e-01 4.836358e-01 2 74835170 74835338 169 + 0.634 0.541 -0.416
ENSG00000159399 E008 78.2989654 0.0068390325 5.343931e-04 2.288511e-03 2 74854293 74854332 40 + 1.936 1.844 -0.312
ENSG00000159399 E009 126.4660614 0.0057036419 8.803760e-04 3.545440e-03 2 74854333 74854455 123 + 2.128 2.069 -0.195
ENSG00000159399 E010 177.8816910 0.0020672057 3.869439e-07 3.497894e-06 2 74867636 74867784 149 + 2.280 2.207 -0.244
ENSG00000159399 E011 0.1515154 0.0432705997 6.223114e-01   2 74867785 74867907 123 + 0.099 0.000 -8.899
ENSG00000159399 E012 158.7945199 0.0006042991 7.826977e-12 1.658054e-10 2 74872300 74872419 120 + 2.242 2.135 -0.356
ENSG00000159399 E013 48.0188541 0.0053173915 5.035398e-04 2.173481e-03 2 74873276 74873277 2 + 1.733 1.615 -0.397
ENSG00000159399 E014 119.4436972 0.0035661380 1.533872e-06 1.223474e-05 2 74873278 74873371 94 + 2.120 2.010 -0.368
ENSG00000159399 E015 165.9800308 0.0019103095 7.905203e-10 1.195225e-08 2 74873844 74873943 100 + 2.263 2.149 -0.380
ENSG00000159399 E016 234.0703755 0.0003431514 2.168342e-13 5.877606e-12 2 74874266 74874449 184 + 2.398 2.320 -0.259
ENSG00000159399 E017 175.6534421 0.0020154256 8.768071e-04 3.533095e-03 2 74877166 74877321 156 + 2.248 2.234 -0.048
ENSG00000159399 E018 0.4418608 0.0266054614 1.335005e-01 2.390017e-01 2 74877939 74877996 58 + 0.246 0.000 -10.483
ENSG00000159399 E019 184.7443152 0.0032071050 1.541061e-03 5.769065e-03 2 74878688 74878921 234 + 2.272 2.251 -0.069
ENSG00000159399 E020 217.3378898 0.0003893842 3.506112e-08 3.893906e-07 2 74880265 74880569 305 + 2.352 2.314 -0.125
ENSG00000159399 E021 178.8924756 0.0042150995 1.018350e-02 2.921666e-02 2 74881711 74881859 149 + 2.254 2.249 -0.015
ENSG00000159399 E022 160.1231920 0.0025517090 5.092273e-02 1.108079e-01 2 74882120 74882239 120 + 2.191 2.220 0.097
ENSG00000159399 E023 4.0104780 0.0155337069 8.403719e-01 9.003384e-01 2 74882240 74882302 63 + 0.659 0.776 0.478
ENSG00000159399 E024 163.0763577 0.0021171047 1.070442e-02 3.046418e-02 2 74885494 74885589 96 + 2.208 2.220 0.041
ENSG00000159399 E025 178.5109502 0.0002051891 6.354691e-03 1.954378e-02 2 74886294 74886393 100 + 2.238 2.268 0.099
ENSG00000159399 E026 260.1510339 0.0001919660 2.240194e-02 5.651181e-02 2 74886490 74886673 184 + 2.391 2.442 0.173
ENSG00000159399 E027 228.6543995 0.0002361986 8.228012e-02 1.631112e-01 2 74887903 74888058 156 + 2.330 2.391 0.204
ENSG00000159399 E028 249.8526591 0.0008490662 4.876226e-01 6.252743e-01 2 74889245 74889478 234 + 2.358 2.441 0.278
ENSG00000159399 E029 1843.7052386 0.0067750635 1.085178e-15 4.075809e-14 2 74890797 74893359 2563 + 3.096 3.416 1.065