ENSG00000159322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311669 ENSG00000159322 HEK293_OSMI2_2hA HEK293_TMG_2hB ADPGK protein_coding protein_coding 47.61049 35.38258 51.34878 4.620293 0.5867779 0.5371639 22.648647 17.7165553 23.567672 2.70308168 0.9269859 0.4115090 0.47295000 0.49906667 0.4588000 -0.040266667 0.728823911 0.000671137 FALSE TRUE
ENST00000456471 ENSG00000159322 HEK293_OSMI2_2hA HEK293_TMG_2hB ADPGK protein_coding protein_coding 47.61049 35.38258 51.34878 4.620293 0.5867779 0.5371639 4.378742 4.9758410 7.224675 1.05499281 2.1316625 0.5370914 0.09957917 0.15276667 0.1416333 -0.011133333 0.977934414 0.000671137 FALSE TRUE
ENST00000562621 ENSG00000159322 HEK293_OSMI2_2hA HEK293_TMG_2hB ADPGK protein_coding retained_intron 47.61049 35.38258 51.34878 4.620293 0.5867779 0.5371639 3.182138 2.0482574 2.876063 0.08580239 0.1017555 0.4876793 0.06734583 0.05943333 0.0560000 -0.003433333 0.947960349 0.000671137 FALSE TRUE
ENST00000569534 ENSG00000159322 HEK293_OSMI2_2hA HEK293_TMG_2hB ADPGK protein_coding nonsense_mediated_decay 47.61049 35.38258 51.34878 4.620293 0.5867779 0.5371639 6.756666 7.6019145 4.605565 3.03688745 0.8545845 -0.7217520 0.15095000 0.20280000 0.0893000 -0.113500000 0.140359820 0.000671137 FALSE TRUE
MSTRG.11173.8 ENSG00000159322 HEK293_OSMI2_2hA HEK293_TMG_2hB ADPGK protein_coding   47.61049 35.38258 51.34878 4.620293 0.5867779 0.5371639 4.907409 0.0796322 6.730783 0.07963220 1.0654578 6.2327552 0.09043333 0.00280000 0.1306667 0.127866667 0.000671137 0.000671137 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159322 E001 1.7650456 0.0083254390 2.904282e-02 7.009013e-02 15 72751294 72751368 75 - 0.201 0.589 2.292
ENSG00000159322 E002 8.2695572 0.0140001934 1.259066e-06 1.023586e-05 15 72751369 72751371 3 - 0.525 1.178 2.581
ENSG00000159322 E003 1270.9750504 0.0012018594 1.090591e-13 3.082338e-12 15 72751372 72752429 1058 - 3.040 3.167 0.423
ENSG00000159322 E004 449.3248081 0.0001864429 4.432647e-01 5.848260e-01 15 72752430 72752634 205 - 2.643 2.674 0.102
ENSG00000159322 E005 535.4919039 0.0001253716 1.048311e-01 1.978476e-01 15 72752635 72752892 258 - 2.738 2.732 -0.020
ENSG00000159322 E006 79.2158493 0.0056048742 8.788092e-02 1.718991e-01 15 72752893 72752895 3 - 1.944 1.867 -0.260
ENSG00000159322 E007 255.1810678 0.0001931760 2.776342e-01 4.172376e-01 15 72755556 72755635 80 - 2.417 2.412 -0.019
ENSG00000159322 E008 151.0610737 0.0002355669 8.935907e-01 9.359397e-01 15 72755636 72755654 19 - 2.178 2.201 0.076
ENSG00000159322 E009 9.8724073 0.0017921867 7.238723e-01 8.175915e-01 15 72755655 72755981 327 - 1.018 1.072 0.197
ENSG00000159322 E010 2.8224194 0.1428649375 8.984783e-01 9.392570e-01 15 72755982 72756161 180 - 0.597 0.551 -0.210
ENSG00000159322 E011 2.9410117 0.0069807915 8.458243e-02 1.667297e-01 15 72756162 72756250 89 - 0.442 0.726 1.290
ENSG00000159322 E012 131.5769327 0.0002733432 2.993397e-01 4.408486e-01 15 72756251 72756260 10 - 2.105 2.155 0.170
ENSG00000159322 E013 372.1163935 0.0001739737 3.483321e-02 8.133016e-02 15 72756261 72756447 187 - 2.588 2.568 -0.067
ENSG00000159322 E014 165.8256639 0.0052539442 9.906321e-01 9.983094e-01 15 72756448 72758610 2163 - 2.220 2.226 0.020
ENSG00000159322 E015 11.5559762 0.0225882353 5.293666e-02 1.143653e-01 15 72760223 72760248 26 - 1.196 0.968 -0.824
ENSG00000159322 E016 19.0928538 0.0091882869 2.571328e-02 6.334512e-02 15 72760249 72760406 158 - 1.389 1.206 -0.643
ENSG00000159322 E017 156.4615777 0.0002300459 4.419460e-05 2.522988e-04 15 72760407 72760417 11 - 2.249 2.152 -0.324
ENSG00000159322 E018 162.6997284 0.0002288619 1.231441e-02 3.428822e-02 15 72760418 72760442 25 - 2.246 2.195 -0.169
ENSG00000159322 E019 220.8206821 0.0002501833 6.522021e-02 1.353998e-01 15 72760443 72760527 85 - 2.365 2.339 -0.087
ENSG00000159322 E020 193.8120209 0.0003141267 3.536769e-04 1.594475e-03 15 72771783 72771845 63 - 2.329 2.254 -0.252
ENSG00000159322 E021 261.9526761 0.0032439492 4.373973e-04 1.918272e-03 15 72774872 72775097 226 - 2.474 2.364 -0.365
ENSG00000159322 E022 0.9148515 0.0468903767 1.202816e-02 3.359735e-02 15 72775098 72775114 17 - 0.000 0.448 11.384
ENSG00000159322 E023 1.9917920 0.0145224048 7.791725e-01 8.579942e-01 15 72780197 72780262 66 - 0.486 0.448 -0.192
ENSG00000159322 E024 10.6511731 0.0016251397 6.097159e-01 7.291368e-01 15 72783246 72783301 56 - 1.041 1.110 0.247
ENSG00000159322 E025 13.6719376 0.0012816636 1.319470e-01 2.368280e-01 15 72783302 72783458 157 - 1.228 1.110 -0.420
ENSG00000159322 E026 130.6128254 0.0059010849 5.880054e-05 3.254905e-04 15 72783459 72783785 327 - 2.203 2.015 -0.631
ENSG00000159322 E027 0.0000000       15 72785649 72785846 198 -