ENSG00000159314

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376922 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding protein_coding 4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 0.8294936 1.49432731 0.69094868 0.18849829 0.16951944 -1.101738 0.15703333 0.23793333 0.16540000 -0.07253333 0.30099794 0.01547728 FALSE TRUE
ENST00000532038 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding protein_coding 4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 2.1055657 3.26420729 1.53415988 0.17272314 0.01088882 -1.084324 0.45881250 0.52896667 0.38600000 -0.14296667 0.27297669 0.01547728 FALSE TRUE
ENST00000581638 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding retained_intron 4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 0.3278608 0.17041264 0.47691937 0.04438089 0.16007252 1.432382 0.07229583 0.02713333 0.11326667 0.08613333 0.01547728 0.01547728 TRUE FALSE
ENST00000581991 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding retained_intron 4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 0.3006967 0.10935270 0.68757218 0.10935270 0.49673640 2.547111 0.06557083 0.01673333 0.15060000 0.13386667 0.48935100 0.01547728 FALSE FALSE
ENST00000590026 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding retained_intron 4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 0.2295554 0.51322391 0.09896172 0.51322391 0.09896172 -2.263607 0.05018333 0.06753333 0.02073333 -0.04680000 1.00000000 0.01547728   FALSE
MSTRG.14490.9 ENSG00000159314 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGAP27 protein_coding   4.647991 6.308532 4.120623 0.8183897 0.5286051 -0.6132299 0.1149560 0.09474719 0.22198643 0.09474719 0.19643093 1.147129 0.02752083 0.01450000 0.07043333 0.05593333 0.76911118 0.01547728 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159314 E001 0.1472490 0.0424164212 0.2403912650   17 45393902 45393907 6 - 0.164 0.000 -10.003
ENSG00000159314 E002 0.1472490 0.0424164212 0.2403912650   17 45393908 45393908 1 - 0.164 0.000 -12.672
ENSG00000159314 E003 2.3926617 0.0142382525 0.3573111373 0.501708565 17 45393909 45393938 30 - 0.376 0.549 0.884
ENSG00000159314 E004 165.0253618 0.0109693036 0.0094225452 0.027337748 17 45393939 45394942 1004 - 2.069 2.218 0.499
ENSG00000159314 E005 72.5725111 0.0004338167 0.1706999292 0.289062601 17 45394943 45395246 304 - 1.766 1.840 0.251
ENSG00000159314 E006 34.0979857 0.0010989378 0.8414110094 0.901094927 17 45395247 45395426 180 - 1.475 1.502 0.091
ENSG00000159314 E007 14.9041926 0.0016966478 0.0737943874 0.149587251 17 45395427 45395454 28 - 1.007 1.199 0.691
ENSG00000159314 E008 11.0407928 0.0016439988 0.0403569437 0.091675342 17 45395455 45395455 1 - 0.843 1.091 0.926
ENSG00000159314 E009 33.1892636 0.0189066902 0.8293540928 0.892851471 17 45395456 45395633 178 - 1.455 1.498 0.146
ENSG00000159314 E010 31.7715705 0.0007435284 0.0194330298 0.050272824 17 45395744 45395849 106 - 1.560 1.426 -0.461
ENSG00000159314 E011 1.8467054 0.0122266296 0.6395864048 0.752948822 17 45395850 45395908 59 - 0.452 0.379 -0.399
ENSG00000159314 E012 30.0775658 0.0047668065 0.0125252891 0.034797021 17 45395983 45396062 80 - 1.560 1.398 -0.556
ENSG00000159314 E013 25.6112582 0.0017788104 0.0341645060 0.080077737 17 45396063 45396117 55 - 1.476 1.338 -0.474
ENSG00000159314 E014 1.8090580 0.0076850599 0.0003596956 0.001617682 17 45396118 45396163 46 - 0.747 0.165 -3.312
ENSG00000159314 E015 25.3308752 0.0007574240 0.1628826717 0.278901243 17 45396207 45396284 78 - 1.434 1.348 -0.298
ENSG00000159314 E016 3.1741512 0.0199198079 0.0002769558 0.001285865 17 45396285 45396486 202 - 0.896 0.334 -2.571
ENSG00000159314 E017 19.0767934 0.0112296845 0.6183205621 0.735996378 17 45396487 45396585 99 - 1.208 1.272 0.227
ENSG00000159314 E018 21.8380716 0.0009314274 0.0514077490 0.111656738 17 45396668 45396790 123 - 1.182 1.357 0.612
ENSG00000159314 E019 26.8604764 0.0007628624 0.5478307563 0.677815697 17 45396916 45397024 109 - 1.362 1.418 0.194
ENSG00000159314 E020 0.9577023 0.0149368667 0.3917032565 0.535635967 17 45397205 45397228 24 - 0.376 0.229 -0.990
ENSG00000159314 E021 3.0624122 0.0051420011 0.3107525703 0.453189603 17 45397514 45397948 435 - 0.669 0.520 -0.666
ENSG00000159314 E022 14.0776369 0.0013836630 0.9840129687 0.994085954 17 45397949 45397964 16 - 1.126 1.137 0.038
ENSG00000159314 E023 25.9759680 0.0013437846 0.8815862378 0.928117060 17 45397965 45398047 83 - 1.370 1.395 0.084
ENSG00000159314 E024 0.9544932 0.0792533475 0.9837885421 0.993935290 17 45401580 45401668 89 - 0.283 0.283 0.001
ENSG00000159314 E025 22.4028823 0.0009233068 0.2087473581 0.337002427 17 45402714 45402773 60 - 1.243 1.356 0.396
ENSG00000159314 E026 23.1665488 0.0009416289 0.5074171007 0.642953679 17 45402774 45402818 45 - 1.297 1.361 0.223
ENSG00000159314 E027 27.7077499 0.0020992673 0.5292553337 0.662058235 17 45403619 45403709 91 - 1.370 1.430 0.206
ENSG00000159314 E028 0.4449813 0.0230198468 0.2360792344 0.369632608 17 45403710 45404028 319 - 0.283 0.090 -1.991
ENSG00000159314 E029 27.5926194 0.0041748230 0.5597133856 0.687786351 17 45404029 45404096 68 - 1.433 1.403 -0.104
ENSG00000159314 E030 0.5953508 0.0442789061 0.4868253108 0.624543547 17 45404097 45404186 90 - 0.283 0.164 -0.997
ENSG00000159314 E031 3.3945748 0.0046208537 0.1172581767 0.216028492 17 45404269 45404334 66 - 0.747 0.520 -0.988
ENSG00000159314 E032 20.1230488 0.0011323309 0.0041906520 0.013679787 17 45404445 45404474 30 - 1.419 1.211 -0.726
ENSG00000159314 E033 22.5253881 0.0029160516 0.0287344235 0.069473306 17 45404475 45404528 54 - 1.433 1.279 -0.536
ENSG00000159314 E034 0.2955422 0.0291507983 0.6011185552   17 45404529 45404600 72 - 0.164 0.090 -0.992
ENSG00000159314 E035 25.5894408 0.0020378824 0.7660954217 0.848680598 17 45404601 45404681 81 - 1.387 1.378 -0.030
ENSG00000159314 E036 0.4417591 0.1397902645 1.0000000000 1.000000000 17 45404682 45404923 242 - 0.164 0.163 -0.010
ENSG00000159314 E037 23.0437485 0.0023883768 0.4675268938 0.607037702 17 45404924 45405027 104 - 1.276 1.349 0.254
ENSG00000159314 E038 21.7902820 0.0009514909 0.7555845058 0.840871386 17 45405028 45405106 79 - 1.316 1.305 -0.039
ENSG00000159314 E039 23.1177503 0.0008642159 0.5014040280 0.637555476 17 45405676 45405846 171 - 1.362 1.324 -0.130
ENSG00000159314 E040 24.2901164 0.0082394908 0.3535531562 0.497808120 17 45405847 45406083 237 - 1.403 1.340 -0.217
ENSG00000159314 E041 0.3697384 0.0274424043 0.4736924476 0.612615630 17 45407533 45410231 2699 - 0.000 0.165 11.487
ENSG00000159314 E042 0.1817044 0.0391081103 1.0000000000   17 45410232 45410426 195 - 0.000 0.090 10.492
ENSG00000159314 E043 8.6285924 0.0551765442 0.8880758752 0.932467128 17 45425564 45425734 171 - 0.966 0.945 -0.077
ENSG00000159314 E044 0.0000000       17 45429352 45429352 1 -      
ENSG00000159314 E045 0.3289534 0.0282032404 0.6014236831   17 45429353 45429622 270 - 0.164 0.090 -0.989
ENSG00000159314 E046 5.3520488 0.0116293969 0.1736686746 0.292958608 17 45429623 45430297 675 - 0.871 0.694 -0.703
ENSG00000159314 E047 3.6064917 0.0763589914 0.5364091901 0.668173109 17 45431621 45431752 132 - 0.518 0.656 0.621
ENSG00000159314 E048 0.8062992 0.0253671362 0.1547548591 0.268095828 17 45432216 45432349 134 - 0.000 0.285 12.418
ENSG00000159314 E049 3.3025330 0.1723142511 0.4431752435 0.584740979 17 45432752 45433746 995 - 0.669 0.559 -0.483
ENSG00000159314 E050 0.8126314 0.0149011593 0.0320769503 0.076005678 17 45434310 45434421 112 - 0.452 0.090 -2.988