ENSG00000159267

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336648 ENSG00000159267 HEK293_OSMI2_2hA HEK293_TMG_2hB HLCS protein_coding protein_coding 9.176682 7.350549 12.87939 0.6564521 0.6366316 0.8082986 0.5498444 0.7435755 0.4099265 0.2042862 0.2603256 -0.8436154 0.06981250 0.09806667 0.03256667 -0.0655000 3.321959e-01 5.839711e-08 FALSE TRUE
ENST00000674895 ENSG00000159267 HEK293_OSMI2_2hA HEK293_TMG_2hB HLCS protein_coding protein_coding 9.176682 7.350549 12.87939 0.6564521 0.6366316 0.8082986 1.0224769 0.9841017 1.6741708 0.1067949 0.1296760 0.7605731 0.11137917 0.13356667 0.13016667 -0.0034000 9.755590e-01 5.839711e-08 FALSE TRUE
MSTRG.21319.11 ENSG00000159267 HEK293_OSMI2_2hA HEK293_TMG_2hB HLCS protein_coding   9.176682 7.350549 12.87939 0.6564521 0.6366316 0.8082986 0.7978390 0.1698551 1.8075258 0.1333308 0.3297649 3.3370691 0.07312083 0.02056667 0.13926667 0.1187000 1.676910e-02 5.839711e-08 FALSE TRUE
MSTRG.21319.4 ENSG00000159267 HEK293_OSMI2_2hA HEK293_TMG_2hB HLCS protein_coding   9.176682 7.350549 12.87939 0.6564521 0.6366316 0.8082986 5.1215859 4.7973244 6.0107045 0.3531241 0.1183592 0.3246982 0.57461250 0.65760000 0.46823333 -0.1893667 1.702145e-02 5.839711e-08 FALSE TRUE
MSTRG.21319.7 ENSG00000159267 HEK293_OSMI2_2hA HEK293_TMG_2hB HLCS protein_coding   9.176682 7.350549 12.87939 0.6564521 0.6366316 0.8082986 0.4956337 0.0000000 1.2976337 0.0000000 0.3123350 7.0308147 0.04182500 0.00000000 0.10020000 0.1002000 5.839711e-08 5.839711e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159267 E001 86.7149304 0.0009970983 5.866023e-01 7.101324e-01 21 36748626 36750887 2262 - 1.913 1.973 0.199
ENSG00000159267 E002 9.5289959 0.0018014153 8.851327e-01 9.305638e-01 21 36750888 36751117 230 - 0.994 1.043 0.183
ENSG00000159267 E003 7.6799699 0.0035197503 2.661177e-01 4.042697e-01 21 36751118 36751191 74 - 0.865 1.026 0.606
ENSG00000159267 E004 238.7087167 0.0131977347 3.577217e-07 3.257983e-06 21 36751192 36752064 873 - 2.209 2.534 1.086
ENSG00000159267 E005 42.1811347 0.0012045760 5.693866e-04 2.419175e-03 21 36752065 36752071 7 - 1.523 1.750 0.771
ENSG00000159267 E006 329.2435121 0.0035542638 6.335885e-07 5.491419e-06 21 36752072 36753141 1070 - 2.425 2.617 0.639
ENSG00000159267 E007 276.1923738 0.0001806697 6.548941e-02 1.358589e-01 21 36753142 36754188 1047 - 2.406 2.482 0.254
ENSG00000159267 E008 89.1384479 0.0003075290 3.050090e-02 7.295101e-02 21 36754189 36754417 229 - 1.897 2.015 0.397
ENSG00000159267 E009 111.5545482 0.0002716559 5.906709e-01 7.135031e-01 21 36756542 36756755 214 - 2.041 2.062 0.068
ENSG00000159267 E010 3.2763859 0.0047863387 8.759423e-01 9.243334e-01 21 36756756 36756980 225 - 0.632 0.638 0.026
ENSG00000159267 E011 83.1458595 0.0004118221 1.003493e-01 1.910084e-01 21 36759727 36759841 115 - 1.934 1.908 -0.088
ENSG00000159267 E012 77.2300625 0.0004062132 5.052657e-03 1.607569e-02 21 36765012 36765172 161 - 1.920 1.843 -0.259
ENSG00000159267 E013 52.7819928 0.0004250037 3.594563e-02 8.347788e-02 21 36767218 36767285 68 - 1.753 1.688 -0.221
ENSG00000159267 E014 1.1405526 0.0112301671 8.672300e-01 9.186090e-01 21 36896570 36896859 290 - 0.304 0.353 0.313
ENSG00000159267 E015 107.5425356 0.0003069213 1.539128e-02 4.137927e-02 21 36896860 36897131 272 - 2.050 2.005 -0.153
ENSG00000159267 E016 76.4257917 0.0019978969 2.700018e-02 6.599712e-02 21 36930251 36930433 183 - 1.911 1.846 -0.218
ENSG00000159267 E017 83.3316199 0.0011137344 4.522738e-03 1.460678e-02 21 36936449 36936676 228 - 1.954 1.873 -0.272
ENSG00000159267 E018 157.5967601 0.0059999900 4.239666e-02 9.543857e-02 21 36936677 36937167 491 - 2.218 2.163 -0.182
ENSG00000159267 E019 55.1802615 0.0026380993 3.018892e-03 1.032228e-02 21 36937168 36937213 46 - 1.790 1.666 -0.422
ENSG00000159267 E020 62.3094977 0.0021317570 1.899196e-04 9.208686e-04 21 36937214 36937275 62 - 1.853 1.699 -0.519
ENSG00000159267 E021 82.8795444 0.0003614287 2.775788e-07 2.586262e-06 21 36937276 36937392 117 - 1.983 1.813 -0.570
ENSG00000159267 E022 82.2259430 0.0032948795 1.182701e-05 7.727777e-05 21 36938832 36938960 129 - 1.980 1.805 -0.589
ENSG00000159267 E023 44.4148760 0.0005290472 3.217761e-06 2.391601e-05 21 36938961 36938994 34 - 1.731 1.511 -0.751
ENSG00000159267 E024 14.5785652 0.0024035721 3.670653e-02 8.491600e-02 21 36946009 36946154 146 - 1.248 1.090 -0.562
ENSG00000159267 E025 15.6040764 0.0048466285 3.462123e-02 8.093994e-02 21 36947333 36948165 833 - 1.278 1.118 -0.566
ENSG00000159267 E026 10.0090791 0.0034700345 3.207869e-02 7.600885e-02 21 36948166 36948287 122 - 1.110 0.910 -0.739
ENSG00000159267 E027 57.6057700 0.0089768231 1.520218e-03 5.702080e-03 21 36962036 36962170 135 - 1.828 1.654 -0.588
ENSG00000159267 E028 9.1050391 0.0020618553 1.892730e-04 9.181674e-04 21 36966444 36966669 226 - 1.127 0.715 -1.565
ENSG00000159267 E029 0.0000000       21 36980372 36980640 269 -      
ENSG00000159267 E030 0.1482932 0.0413888664 3.266978e-01   21 36980641 36980783 143 - 0.000 0.152 10.047
ENSG00000159267 E031 0.2955422 0.0293299592 7.633652e-01   21 36980784 36980964 181 - 0.098 0.152 0.725
ENSG00000159267 E032 18.0057517 0.0031447588 1.108335e-02 3.136653e-02 21 36990158 36990238 81 - 1.342 1.158 -0.647