ENSG00000159216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344691 ENSG00000159216 HEK293_OSMI2_2hA HEK293_TMG_2hB RUNX1 protein_coding protein_coding 1.050169 1.38411 0.6624648 0.003958141 0.01095345 -1.051814 0.66423593 0.89530112 0.6545428 0.08035059 0.009840564 -0.4460355 0.69067917 0.64713333 0.9882333 0.34110000 0.0001157799 0.0001157799 FALSE TRUE
ENST00000358356 ENSG00000159216 HEK293_OSMI2_2hA HEK293_TMG_2hB RUNX1 protein_coding protein_coding 1.050169 1.38411 0.6624648 0.003958141 0.01095345 -1.051814 0.05897614 0.14181222 0.0000000 0.08426216 0.000000000 -3.9242160 0.04801667 0.10226667 0.0000000 -0.10226667 0.1622886480 0.0001157799 FALSE TRUE
ENST00000399237 ENSG00000159216 HEK293_OSMI2_2hA HEK293_TMG_2hB RUNX1 protein_coding protein_coding 1.050169 1.38411 0.6624648 0.003958141 0.01095345 -1.051814 0.06327578 0.07143602 0.0000000 0.07143602 0.000000000 -3.0256671 0.05665833 0.05143333 0.0000000 -0.05143333 0.8728249866 0.0001157799 FALSE FALSE
ENST00000399240 ENSG00000159216 HEK293_OSMI2_2hA HEK293_TMG_2hB RUNX1 protein_coding protein_coding 1.050169 1.38411 0.6624648 0.003958141 0.01095345 -1.051814 0.17985677 0.23965885 0.0000000 0.08660231 0.000000000 -4.6418862 0.14591250 0.17320000 0.0000000 -0.17320000 0.0129335609 0.0001157799 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159216 E001 86.8264568 0.0006753685 0.71837515 0.81349236 21 34787801 34791754 3954 - 1.920 1.912 -0.025
ENSG00000159216 E002 2.2282290 0.1322744317 0.01533841 0.04125645 21 34791755 34791785 31 - 0.755 0.244 -2.635
ENSG00000159216 E003 24.8412351 0.0009006728 0.77072558 0.85198549 21 34791786 34792610 825 - 1.395 1.378 -0.057
ENSG00000159216 E004 12.1735476 0.0099139177 0.52893878 0.66180053 21 34799301 34799462 162 - 1.049 1.120 0.255
ENSG00000159216 E005 1.2448491 0.0376286270 0.02471690 0.06129654 21 34821279 34821696 418 - 0.000 0.438 12.625
ENSG00000159216 E006 0.0000000       21 34829852 34829970 119 -      
ENSG00000159216 E007 0.4031496 0.0260779778 0.38708015 0.53123133 21 34832961 34834409 1449 - 0.000 0.176 10.976
ENSG00000159216 E008 12.9624712 0.0015470239 0.75513135 0.84055966 21 34834410 34834601 192 - 1.096 1.129 0.116
ENSG00000159216 E009 0.0000000       21 34856289 34856298 10 -      
ENSG00000159216 E010 0.0000000       21 34856299 34856447 149 -      
ENSG00000159216 E011 11.4637082 0.0015908550 0.73543195 0.82619980 21 34859474 34859578 105 - 1.050 1.086 0.133
ENSG00000159216 E012 7.3821439 0.0024105632 0.49676568 0.63335869 21 34880557 34880605 49 - 0.842 0.928 0.326
ENSG00000159216 E013 10.0716086 0.0017740966 0.77888459 0.85775193 21 34880606 34880713 108 - 0.997 1.030 0.120
ENSG00000159216 E014 7.2390632 0.0036800188 0.79252560 0.86733407 21 34886843 34887045 203 - 0.916 0.887 -0.107
ENSG00000159216 E015 2.0743200 0.0111569022 0.49242575 0.62961068 21 34887046 34887096 51 - 0.551 0.438 -0.553
ENSG00000159216 E016 1.6691813 0.0171926705 0.14718832 0.25785689 21 34887097 34887183 87 - 0.551 0.300 -1.356
ENSG00000159216 E017 34.4988694 0.0034228239 0.75367310 0.83953331 21 34887184 34888690 1507 - 1.506 1.527 0.073
ENSG00000159216 E018 0.5117019 0.0327779483 0.20555144 0.33310611 21 34889677 34889790 114 - 0.000 0.242 11.505
ENSG00000159216 E019 0.0000000       21 34892925 34892963 39 -      
ENSG00000159216 E020 0.0000000       21 35048842 35048958 117 -      
ENSG00000159216 E021 0.0000000       21 35048959 35049080 122 -      
ENSG00000159216 E022 0.0000000       21 35049081 35049167 87 -      
ENSG00000159216 E023 0.0000000       21 35049168 35049270 103 -      
ENSG00000159216 E024 0.0000000       21 35049271 35049288 18 -      
ENSG00000159216 E025 0.0000000       21 35049289 35049298 10 -      
ENSG00000159216 E026 0.0000000       21 35049299 35049302 4 -      
ENSG00000159216 E027 0.0000000       21 35049303 35049344 42 -      
ENSG00000159216 E028 0.0000000       21 35064716 35064829 114 -      
ENSG00000159216 E029 0.0000000       21 35064936 35065072 137 -      
ENSG00000159216 E030 0.0000000       21 35372507 35372793 287 -      
ENSG00000159216 E031 0.0000000       21 35435661 35439071 3411 -      
ENSG00000159216 E032 0.0000000       21 35461961 35462025 65 -      
ENSG00000159216 E033 0.0000000       21 35465184 35465329 146 -      
ENSG00000159216 E034 0.0000000       21 35580660 35580760 101 -      
ENSG00000159216 E035 0.0000000       21 35580761 35580929 169 -      
ENSG00000159216 E036 0.0000000       21 35654820 35654875 56 -      
ENSG00000159216 E037 0.0000000       21 35864285 35864467 183 -      
ENSG00000159216 E038 0.0000000       21 35954660 35954825 166 -      
ENSG00000159216 E039 0.0000000       21 35970075 35970167 93 -      
ENSG00000159216 E040 0.0000000       21 35981751 35981916 166 -      
ENSG00000159216 E041 0.0000000       21 35984572 35984749 178 -      
ENSG00000159216 E042 0.0000000       21 35984750 35984830 81 -      
ENSG00000159216 E043 0.0000000       21 35988130 35988171 42 -      
ENSG00000159216 E044 0.0000000       21 36004564 36004667 104 -