ENSG00000159202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360943 ENSG00000159202 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Z protein_coding protein_coding 62.08485 87.41324 51.46527 1.381941 0.8147728 -0.7641373 35.226027 44.329704 35.679026 4.6535530 0.6070199 -0.3131186 0.5865708 0.50646667 0.69323333 0.18676667 1.006797e-02 1.631533e-11 FALSE TRUE
ENST00000504684 ENSG00000159202 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Z protein_coding nonsense_mediated_decay 62.08485 87.41324 51.46527 1.381941 0.8147728 -0.7641373 9.820736 19.986512 2.837359 3.0315462 1.0872180 -2.8120519 0.1386000 0.22870000 0.05453333 -0.17416667 1.312600e-03 1.631533e-11 FALSE TRUE
ENST00000506498 ENSG00000159202 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Z protein_coding nonsense_mediated_decay 62.08485 87.41324 51.46527 1.381941 0.8147728 -0.7641373 8.618722 18.608307 3.375405 0.8147720 1.0668398 -2.4593217 0.1252333 0.21320000 0.06623333 -0.14696667 3.988069e-03 1.631533e-11 FALSE TRUE
ENST00000511373 ENSG00000159202 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2Z protein_coding protein_coding 62.08485 87.41324 51.46527 1.381941 0.8147728 -0.7641373 2.924958 1.201426 4.280139 0.2012788 0.3871620 1.8243183 0.0545250 0.01376667 0.08323333 0.06946667 2.198006e-11 1.631533e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159202 E001 61.29919 0.0290026702 8.590608e-02 1.688332e-01 17 48908407 48908472 66 + 1.805 1.762 -0.145
ENSG00000159202 E002 118.57539 0.0312126946 1.860239e-03 6.789910e-03 17 48908473 48908715 243 + 2.157 1.993 -0.549
ENSG00000159202 E003 126.47849 0.0032864688 1.260487e-08 1.525460e-07 17 48908716 48908820 105 + 2.165 2.038 -0.427
ENSG00000159202 E004 32.22585 0.0010757146 1.057165e-30 1.871744e-28 17 48910348 48910689 342 + 1.787 1.156 -2.177
ENSG00000159202 E005 18.50004 0.0078321223 1.511901e-15 5.585514e-14 17 48910690 48910807 118 + 1.553 0.930 -2.209
ENSG00000159202 E006 236.00573 0.0010708991 9.566802e-12 2.000223e-10 17 48910808 48910880 73 + 2.407 2.329 -0.261
ENSG00000159202 E007 67.56604 0.0028373994 1.844068e-29 2.938210e-27 17 48911179 48912833 1655 + 2.046 1.595 -1.525
ENSG00000159202 E008 422.77599 0.0003757040 1.056287e-15 3.975178e-14 17 48912834 48912965 132 + 2.639 2.596 -0.145
ENSG00000159202 E009 367.61603 0.0001850569 1.465697e-08 1.752537e-07 17 48912966 48913021 56 + 2.552 2.553 0.002
ENSG00000159202 E010 18.53660 0.0695000749 3.473917e-02 8.114891e-02 17 48915720 48916075 356 + 1.386 1.206 -0.630
ENSG00000159202 E011 482.87566 0.0001261275 4.264946e-09 5.624261e-08 17 48916076 48916187 112 + 2.663 2.675 0.041
ENSG00000159202 E012 359.90590 0.0001946199 2.108797e-07 2.012926e-06 17 48921160 48921201 42 + 2.539 2.547 0.029
ENSG00000159202 E013 425.89772 0.0018344265 1.405004e-01 2.487257e-01 17 48921202 48921272 71 + 2.570 2.641 0.236
ENSG00000159202 E014 455.85482 0.0028079110 7.590188e-01 8.434793e-01 17 48922847 48922937 91 + 2.579 2.680 0.336
ENSG00000159202 E015 1.76837 0.0293080388 3.985568e-01 5.422914e-01 17 48922938 48923097 160 + 0.463 0.380 -0.448
ENSG00000159202 E016 4366.34359 0.0035211617 5.295725e-14 1.565880e-12 17 48926964 48929056 2093 + 3.481 3.695 0.712