ENSG00000159140

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300278 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding protein_coding 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 7.601287 7.5220911 7.74674755 0.8390205 0.56477118 0.04240140 0.058183333 0.056166667 0.0476333333 -0.008533333 6.108338e-01 1.785304e-135 FALSE TRUE
ENST00000356577 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding protein_coding 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 17.314185 1.7324669 33.40957454 1.7324669 2.13059482 4.26149023 0.122062500 0.011866667 0.2049666667 0.193100000 2.199751e-02 1.785304e-135 FALSE TRUE
ENST00000381679 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding protein_coding 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 17.425183 20.2106206 20.42821994 1.9285017 0.15289874 0.01544227 0.130416667 0.150966667 0.1254666667 -0.025500000 1.131844e-01 1.785304e-135 FALSE TRUE
ENST00000381692 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding protein_coding 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 15.359815 41.0415083 0.23543732 0.8326801 0.16690704 -7.38593679 0.119454167 0.308700000 0.0014333333 -0.307266667 4.209400e-09 1.785304e-135 FALSE TRUE
ENST00000429093 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding nonsense_mediated_decay 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 6.229821 1.0725440 11.50569528 0.3313555 0.86771967 3.41110392 0.045483333 0.007900000 0.0705666667 0.062666667 7.606434e-08 1.785304e-135   FALSE
ENST00000436227 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding protein_coding 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 18.875187 20.2135048 14.03315871 3.2790256 0.97483457 -0.52616556 0.145175000 0.150100000 0.0862333333 -0.063866667 2.731819e-02 1.785304e-135 FALSE TRUE
ENST00000470533 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding processed_transcript 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 1.350934 7.5942224 0.00000000 1.3124594 0.00000000 -9.57065692 0.009733333 0.056500000 0.0000000000 -0.056500000 4.921828e-34 1.785304e-135 FALSE TRUE
ENST00000478183 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding retained_intron 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 7.000731 2.1242002 10.01482415 0.2178836 0.74933422 2.23180951 0.054395833 0.015933333 0.0615666667 0.045633333 4.449506e-13 1.785304e-135 FALSE TRUE
ENST00000491794 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding retained_intron 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 7.962508 23.1442985 0.08399484 4.8961878 0.08399484 -7.94448284 0.060529167 0.176400000 0.0005333333 -0.175866667 7.929161e-07 1.785304e-135 FALSE TRUE
ENST00000492229 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding processed_transcript 134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 12.330902 0.0000000 29.77174209 0.0000000 0.80766931 11.54021243 0.083325000 0.000000000 0.1827666667 0.182766667 1.785304e-135 1.785304e-135   FALSE
MSTRG.21290.1 ENSG00000159140 HEK293_OSMI2_2hA HEK293_TMG_2hB SON protein_coding   134.3472 133.3074 162.8766 6.456271 1.230132 0.2890031 4.971229 0.9224392 9.64065759 0.1398367 1.43269775 3.37154565 0.035587500 0.006866667 0.0593333333 0.052466667 2.573942e-12 1.785304e-135 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159140 E001 3.0581484 5.166319e-03 5.782031e-01 7.033578e-01 21 33542968 33543037 70 + 0.667 0.537 -0.580
ENSG00000159140 E002 19.9873096 8.946513e-04 2.582638e-02 6.358324e-02 21 33543038 33543051 14 + 1.424 1.194 -0.803
ENSG00000159140 E003 25.4122237 7.592862e-04 1.491286e-01 2.604901e-01 21 33543052 33543056 5 + 1.497 1.340 -0.540
ENSG00000159140 E004 34.7781265 6.002567e-04 7.498558e-02 1.515139e-01 21 33543057 33543063 7 + 1.630 1.466 -0.561
ENSG00000159140 E005 37.4501804 5.847784e-04 1.366545e-02 3.746405e-02 21 33543064 33543064 1 + 1.677 1.476 -0.686
ENSG00000159140 E006 41.7714544 1.681839e-03 7.785363e-03 2.324016e-02 21 33543065 33543069 5 + 1.727 1.515 -0.722
ENSG00000159140 E007 354.9337627 3.302724e-03 4.912650e-02 1.075963e-01 21 33543070 33543169 100 + 2.612 2.486 -0.419
ENSG00000159140 E008 548.7475915 5.285221e-03 1.585887e-01 2.732429e-01 21 33546213 33546379 167 + 2.795 2.682 -0.374
ENSG00000159140 E009 0.4449813 2.154734e-02 7.360563e-01 8.266610e-01 21 33546380 33546752 373 + 0.206 0.130 -0.805
ENSG00000159140 E010 0.1472490 4.311359e-02 6.259408e-01   21 33547001 33547039 39 + 0.115 0.000 -9.487
ENSG00000159140 E011 1779.6961712 2.967983e-03 3.166374e-17 1.447888e-15 21 33549476 33550661 1186 + 3.371 3.093 -0.926
ENSG00000159140 E012 329.7374832 2.662236e-03 5.188569e-29 8.009128e-27 21 33550662 33550728 67 + 2.687 2.261 -1.419
ENSG00000159140 E013 2158.3390275 1.136414e-02 1.798869e-12 4.227119e-11 21 33550729 33552247 1519 + 3.493 3.099 -1.309
ENSG00000159140 E014 5443.4329082 3.709552e-03 7.295413e-09 9.216419e-08 21 33552248 33555048 2801 + 3.823 3.633 -0.632
ENSG00000159140 E015 704.9553577 4.406908e-04 4.274583e-01 5.703107e-01 21 33555049 33555391 343 + 2.870 2.824 -0.151
ENSG00000159140 E016 803.0624521 9.220074e-05 1.459090e-04 7.295141e-04 21 33557156 33557316 161 + 2.908 2.899 -0.032
ENSG00000159140 E017 1123.8100596 3.788189e-03 6.807875e-20 4.263575e-18 21 33557546 33559229 1684 + 2.920 3.147 0.755
ENSG00000159140 E018 711.1450494 3.405723e-04 2.009880e-07 1.924712e-06 21 33559230 33559376 147 + 2.839 2.862 0.078
ENSG00000159140 E019 902.8340361 1.110549e-04 2.251017e-20 1.503167e-18 21 33559587 33559775 189 + 2.924 2.981 0.190
ENSG00000159140 E020 224.8340939 1.201836e-02 1.859985e-10 3.132723e-09 21 33559877 33560667 791 + 2.158 2.480 1.073
ENSG00000159140 E021 271.3093902 1.863228e-04 2.866832e-06 2.154696e-05 21 33567157 33567159 3 + 2.408 2.453 0.150
ENSG00000159140 E022 380.0377181 1.445358e-04 1.778261e-10 3.006165e-09 21 33567160 33567178 19 + 2.546 2.607 0.204
ENSG00000159140 E023 361.7165827 1.677384e-04 3.165868e-10 5.135406e-09 21 33567179 33567184 6 + 2.523 2.586 0.211
ENSG00000159140 E024 578.5991846 1.875525e-04 1.177164e-23 1.122912e-21 21 33567185 33567267 83 + 2.706 2.807 0.336
ENSG00000159140 E025 1.9488264 7.610046e-03 9.313678e-03 2.706624e-02 21 33567268 33567467 200 + 0.206 0.617 2.368
ENSG00000159140 E026 660.0989832 1.191905e-04 5.371599e-34 1.223117e-31 21 33568971 33569087 117 + 2.754 2.871 0.392
ENSG00000159140 E027 47.3107130 2.125014e-02 2.225239e-20 1.486477e-18 21 33569088 33569302 215 + 1.953 0.925 -3.583
ENSG00000159140 E028 44.6627699 4.868649e-03 1.214848e-30 2.140924e-28 21 33569576 33569775 200 + 1.921 0.972 -3.296
ENSG00000159140 E029 52.9863863 4.231112e-03 1.376327e-38 4.352940e-36 21 33569776 33569930 155 + 2.001 0.988 -3.507
ENSG00000159140 E030 48.7349481 2.727593e-03 2.193491e-43 9.317270e-41 21 33570095 33570198 104 + 1.972 0.882 -3.807
ENSG00000159140 E031 24.3436785 7.997955e-03 5.093099e-13 1.309722e-11 21 33571735 33571750 16 + 1.636 0.902 -2.599
ENSG00000159140 E032 36.2473886 1.094387e-03 8.784454e-28 1.220975e-25 21 33571751 33571788 38 + 1.822 0.971 -2.966
ENSG00000159140 E033 46.0414504 4.340653e-03 1.790793e-30 3.126824e-28 21 33571789 33571868 80 + 1.931 1.018 -3.162
ENSG00000159140 E034 38.7887295 6.278218e-04 1.623132e-33 3.554884e-31 21 33571869 33571903 35 + 1.858 0.938 -3.214
ENSG00000159140 E035 62.5624746 6.450747e-04 7.492247e-36 1.933765e-33 21 33572213 33572526 314 + 2.036 1.312 -2.463
ENSG00000159140 E036 33.8317091 6.520577e-04 2.661570e-20 1.759338e-18 21 33572527 33572550 24 + 1.771 1.072 -2.427
ENSG00000159140 E037 77.9968396 6.576126e-03 1.620122e-11 3.258944e-10 21 33572551 33572630 80 + 2.071 1.613 -1.546
ENSG00000159140 E038 39.0987517 5.278761e-04 7.721215e-16 2.959856e-14 21 33573025 33573213 189 + 1.804 1.249 -1.905
ENSG00000159140 E039 34.4410715 8.135667e-04 1.612262e-07 1.574100e-06 21 33573214 33573307 94 + 1.706 1.319 -1.328
ENSG00000159140 E040 937.3249198 9.272170e-05 2.896915e-41 1.084608e-38 21 33573308 33573455 148 + 2.913 3.018 0.349
ENSG00000159140 E041 624.7783429 3.290315e-04 7.302361e-46 3.556325e-43 21 33575596 33575667 72 + 2.695 2.872 0.588
ENSG00000159140 E042 517.3446284 1.344656e-03 5.720481e-18 2.885325e-16 21 33575778 33575893 116 + 2.633 2.778 0.484
ENSG00000159140 E043 154.1426594 2.809197e-03 1.059070e-15 3.984068e-14 21 33576365 33576417 53 + 2.039 2.293 0.850
ENSG00000159140 E044 2684.3479579 5.462951e-03 1.256162e-26 1.570799e-24 21 33576418 33577481 1064 + 3.249 3.550 1.000