ENSG00000159111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351111 ENSG00000159111 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL10 protein_coding protein_coding 73.61519 124.49 44.00441 3.369151 0.3847709 -1.500098 52.852957 100.943819 22.855351 1.5238474 1.2387418 -2.1424605 0.6767417 0.8115000 0.5199333 -0.29156667 8.876636e-10 8.876636e-10 FALSE TRUE
ENST00000414011 ENSG00000159111 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL10 protein_coding protein_coding 73.61519 124.49 44.00441 3.369151 0.3847709 -1.500098 11.161232 15.241220 9.801622 0.6620855 0.9851704 -0.6363611 0.1675875 0.1226667 0.2226000 0.09993333 1.025913e-03 8.876636e-10 FALSE TRUE
MSTRG.14563.6 ENSG00000159111 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL10 protein_coding   73.61519 124.49 44.00441 3.369151 0.3847709 -1.500098 6.213245 4.478961 8.660370 1.8536258 0.8379587 0.9497120 0.1028000 0.0352000 0.1965333 0.16133333 1.146062e-02 8.876636e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159111 E001 10.561733 0.0086284626 7.268533e-03 2.192259e-02 17 47823272 47823460 189 - 0.613 1.028 1.639
ENSG00000159111 E002 38.073513 0.0035850283 9.686884e-03 2.799150e-02 17 47823461 47823489 29 - 1.307 1.524 0.753
ENSG00000159111 E003 341.167338 0.0032363865 1.778353e-02 4.667096e-02 17 47823490 47823574 85 - 2.348 2.441 0.312
ENSG00000159111 E004 274.199798 0.0034620798 1.547217e-01 2.680551e-01 17 47823575 47823582 8 - 2.280 2.342 0.209
ENSG00000159111 E005 1599.048775 0.0021308354 3.850725e-02 8.829115e-02 17 47823583 47824015 433 - 3.054 3.103 0.163
ENSG00000159111 E006 1599.277690 0.0001077618 7.967966e-01 8.703289e-01 17 47824016 47824458 443 - 3.092 3.094 0.007
ENSG00000159111 E007 290.348649 0.0002208752 4.322642e-02 9.696654e-02 17 47826637 47826676 40 - 2.306 2.365 0.197
ENSG00000159111 E008 573.601453 0.0005451556 8.482452e-01 9.057580e-01 17 47826677 47826781 105 - 2.648 2.649 0.003
ENSG00000159111 E009 2.260479 0.1180413344 1.090858e-01 2.041956e-01 17 47826895 47827039 145 - 0.675 0.345 -1.620
ENSG00000159111 E010 420.286194 0.0006594642 2.641712e-02 6.478085e-02 17 47827040 47827073 34 - 2.552 2.505 -0.159
ENSG00000159111 E011 763.461449 0.0014971813 2.644631e-02 6.484068e-02 17 47827074 47827201 128 - 2.809 2.764 -0.150
ENSG00000159111 E012 374.080803 0.0032603120 2.969461e-01 4.382298e-01 17 47827202 47827204 3 - 2.489 2.458 -0.103
ENSG00000159111 E013 3.883374 0.0471048562 4.451475e-02 9.930742e-02 17 47828308 47828500 193 - 0.858 0.527 -1.392
ENSG00000159111 E014 751.790747 0.0016570729 1.324866e-01 2.375423e-01 17 47828501 47828670 170 - 2.791 2.760 -0.101
ENSG00000159111 E015 22.370815 0.0012542123 4.934236e-07 4.368317e-06 17 47829139 47829236 98 - 1.546 1.161 -1.342
ENSG00000159111 E016 10.940447 0.0016864007 7.730706e-08 8.023662e-07 17 47829237 47829673 437 - 1.357 0.821 -1.950
ENSG00000159111 E017 12.593548 0.0013552528 3.430343e-02 8.033776e-02 17 47831311 47831459 149 - 1.202 0.987 -0.778
ENSG00000159111 E018 323.407268 0.0012098589 9.331333e-01 9.618496e-01 17 47831460 47831541 82 - 2.394 2.401 0.024