ENSG00000159086

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331923 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding protein_coding 23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 8.819750 4.66062163 14.020845 0.55185055 0.4080262 1.586915 0.44362083 0.666800000 0.37250000 -0.294300000 4.269969e-14 4.269969e-14 FALSE TRUE
ENST00000464256 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding retained_intron 23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 2.244558 0.28535322 4.013694 0.06096162 0.6314644 3.768007 0.07937500 0.042300000 0.10586667 0.063566667 3.913427e-02 4.269969e-14 FALSE TRUE
ENST00000466846 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding retained_intron 23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 4.608809 0.93169273 6.920354 0.18482320 0.3580757 2.879601 0.19357500 0.130733333 0.18346667 0.052733333 1.172271e-01 4.269969e-14 FALSE TRUE
ENST00000497873 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding retained_intron 23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 2.116841 0.31388750 3.094501 0.13618802 0.1094082 3.260796 0.08570000 0.042833333 0.08220000 0.039366667 1.756179e-01 4.269969e-14 FALSE TRUE
MSTRG.21256.13 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding   23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 2.237560 0.05505805 4.084117 0.01052512 0.2227533 5.975681 0.06763333 0.008233333 0.10830000 0.100066667 8.963707e-14 4.269969e-14 FALSE TRUE
MSTRG.21256.8 ENSG00000159086 HEK293_OSMI2_2hA HEK293_TMG_2hB PAXBP1 protein_coding   23.17937 7.00502 37.67032 0.8657666 1.199023 2.425292 1.656202 0.59621051 3.002326 0.12055824 0.4356471 2.312987 0.08044583 0.088966667 0.07923333 -0.009733333 9.086508e-01 4.269969e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000159086 E001 0.1482932 0.0418968920 1.053718e-01   21 32733790 32733898 109 - 0.000 0.221 12.448
ENSG00000159086 E002 0.1817044 0.0400787984 1.048105e-01   21 32733899 32733899 1 - 0.000 0.221 12.495
ENSG00000159086 E003 214.9568290 0.0049658406 4.863633e-11 9.056425e-10 21 32733900 32734429 530 - 2.174 2.458 0.949
ENSG00000159086 E004 219.6438672 0.0002987311 2.303757e-29 3.652217e-27 21 32734430 32734819 390 - 2.174 2.479 1.016
ENSG00000159086 E005 29.5844167 0.0007847375 1.128965e-11 2.330598e-10 21 32734820 32734825 6 - 1.253 1.717 1.594
ENSG00000159086 E006 145.0718326 0.0007609135 6.232278e-10 9.610015e-09 21 32734826 32735067 242 - 2.024 2.246 0.746
ENSG00000159086 E007 152.7076738 0.0003777961 3.687898e-03 1.226087e-02 21 32737254 32737408 155 - 2.081 2.188 0.361
ENSG00000159086 E008 93.9576252 0.0005108608 3.962869e-02 9.034118e-02 21 32738173 32738214 42 - 1.871 1.970 0.333
ENSG00000159086 E009 109.5094157 0.0032904258 4.266921e-02 9.593813e-02 21 32738215 32738319 105 - 1.936 2.043 0.359
ENSG00000159086 E010 7.5133508 0.0029152500 9.087822e-01 9.460609e-01 21 32741324 32741392 69 - 0.859 0.883 0.091
ENSG00000159086 E011 6.3632333 0.0034051151 9.099768e-01 9.467683e-01 21 32741393 32741418 26 - 0.808 0.800 -0.033
ENSG00000159086 E012 25.6821888 0.0068126967 1.830317e-03 6.696303e-03 21 32741419 32741622 204 - 1.276 1.542 0.919
ENSG00000159086 E013 6.1481929 0.0262353412 1.268264e-01 2.297301e-01 21 32742360 32742501 142 - 0.829 0.564 -1.110
ENSG00000159086 E014 3.3664924 0.0052079934 7.328891e-01 8.242572e-01 21 32742961 32743066 106 - 0.570 0.635 0.289
ENSG00000159086 E015 101.9253872 0.0003270628 3.361706e-02 7.899788e-02 21 32743248 32743314 67 - 1.908 2.005 0.325
ENSG00000159086 E016 122.3380929 0.0020657826 3.089943e-02 7.372085e-02 21 32743678 32743754 77 - 1.985 2.087 0.341
ENSG00000159086 E017 159.4111164 0.0019660546 5.054317e-01 6.412142e-01 21 32744792 32744913 122 - 2.114 2.152 0.126
ENSG00000159086 E018 174.2627387 0.0013836370 6.033336e-01 7.241448e-01 21 32745574 32745718 145 - 2.165 2.156 -0.030
ENSG00000159086 E019 109.3935245 0.0002729712 5.901043e-01 7.130323e-01 21 32748499 32748558 60 - 1.956 1.988 0.106
ENSG00000159086 E020 138.0558868 0.0002243482 3.867707e-01 5.309490e-01 21 32748559 32748698 140 - 2.068 2.046 -0.073
ENSG00000159086 E021 124.5814512 0.0003251408 1.078443e-01 2.023430e-01 21 32750917 32751032 116 - 2.029 1.976 -0.180
ENSG00000159086 E022 123.0732801 0.0004310572 3.942368e-01 5.380984e-01 21 32751119 32751218 100 - 2.018 1.994 -0.079
ENSG00000159086 E023 37.6150486 0.0076555296 2.909676e-04 1.343086e-03 21 32751219 32752124 906 - 1.563 1.246 -1.099
ENSG00000159086 E024 24.0779806 0.0008982733 3.475858e-01 4.917988e-01 21 32755213 32755229 17 - 1.334 1.261 -0.255
ENSG00000159086 E025 120.9105567 0.0003066861 9.524564e-02 1.832418e-01 21 32755230 32755353 124 - 1.988 2.061 0.246
ENSG00000159086 E026 96.2075555 0.0003252451 3.073247e-13 8.146319e-12 21 32755354 32756341 988 - 1.968 1.596 -1.257
ENSG00000159086 E027 15.9189772 0.0015865294 1.514887e-07 1.486152e-06 21 32756342 32756368 27 - 1.246 0.476 -3.061
ENSG00000159086 E028 49.9055435 0.0004719862 1.476483e-12 3.518875e-11 21 32756369 32756794 426 - 1.705 1.154 -1.903
ENSG00000159086 E029 31.4724522 0.0043860096 1.088997e-10 1.910605e-09 21 32758894 32759079 186 - 1.522 0.800 -2.602
ENSG00000159086 E030 143.9847127 0.0018479066 3.217394e-02 7.619165e-02 21 32759080 32759269 190 - 2.099 2.020 -0.263
ENSG00000159086 E031 33.4630797 0.0048480165 1.170886e-02 3.283753e-02 21 32759402 32759776 375 - 1.501 1.292 -0.723
ENSG00000159086 E032 161.4883205 0.0002147355 1.660569e-05 1.048983e-04 21 32759777 32759994 218 - 2.161 2.016 -0.484
ENSG00000159086 E033 119.1041833 0.0014733151 2.096081e-05 1.294021e-04 21 32761059 32761162 104 - 2.035 1.850 -0.622
ENSG00000159086 E034 152.6825825 0.0002724701 1.312994e-08 1.583643e-07 21 32762096 32762314 219 - 2.145 1.938 -0.696
ENSG00000159086 E035 46.3802873 0.0005475324 8.825587e-04 3.553097e-03 21 32762315 32762317 3 - 1.638 1.419 -0.752
ENSG00000159086 E036 132.1449401 0.0023546817 1.315735e-06 1.064949e-05 21 32764348 32764524 177 - 2.085 1.866 -0.736
ENSG00000159086 E037 98.6179253 0.0002892804 3.965019e-10 6.327164e-09 21 32769814 32769942 129 - 1.971 1.670 -1.016
ENSG00000159086 E038 87.0693217 0.0003102310 2.381191e-09 3.293973e-08 21 32771326 32771793 468 - 1.918 1.611 -1.038